1-(3-甲基喹喔啉-2-基)乙醇 | 104217-24-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 1-(3-甲基喹喔啉-2-基)乙醇
• 中文别名: 2-喹喔啉甲醇,-α-,3-二甲基-(6CI)
• 英文名称: 1-(3-methylquinoxalin-2-yl)ethan-1-ol
• 英文别名: 1-(3-methylquinoxalin-2-yl)ethanol；2-isoethanol bisdesoxymequindox；1-(3-methyl-quinoxalin-2-yl)-ethanol；1-(3-Methyl-chinoxalin-2-yl)-aethanol
• CAS: 104217-24-5
• 化学式: C₁₁H₁₂N₂O
• 分子量: 188.229
• InChiKey: AOGWWPQTCFVNAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  46
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  1-(3-甲基喹喔啉-2-基)乙酮 在 甲醇 、 钾硼氢 作用下， 生成 1-(3-甲基喹喔啉-2-基)乙醇
  参考文献：
  名称：

  Barltrop et al., Journal of the Chemical Society, 1959, p. 1423,1428

  摘要：

  DOI：

文献信息

• 一种抗菌促生长动物专用药3-甲基-2-乙醇基 喹噁啉的合成方法
  申请人：杭州洪晟生物技术股份有限公司

  公开号：CN106632096B

  公开（公告）日：2019-04-19

  本发明提供了一种抗菌促生长动物专用药3‑甲基‑2‑乙醇基喹噁啉的合成方法，向反应器中加入乙酰甲喹、相转移催化剂和溶剂四氢呋喃，室温搅拌后缓慢加入单一还原剂，反应0.5‑5小时，反应结束后经过后处理得到3‑甲基‑2‑乙醇基喹噁啉。该方法反应步骤短，仅需一步，操作简便、效率高，产品的收率和纯度较高，反应条件温和，适宜工业化生产。
• 403. Quinoxaline N-oxides. Part IV. Derivatives of Py-hydroxyalkyl-, -aminoalkyl-, and -carboxy-quinoxalines
  作者：Justus K. Landquist、J. A. Silk

  DOI：10.1039/jr9560002052

  日期：——
• Synthetic Analogs Tailor Native AI-2 Signaling Across Bacterial Species
  作者：Varnika Roy、Jacqueline A. I. Smith、Jingxin Wang、Jessica E. Stewart、William E. Bentley、Herman O. Sintim

  DOI：10.1021/ja102587w

  日期：2010.8.18

  The widespread use of antibiotics and the emergence of resistant strains call for new approaches to treat bacterial infection. Bacterial cell cell communication or "quorum sensing" (QS) is mediated by "signatures" of small molecules that represent targets for "quenching" communication and avoiding virulent phenotypes. Only a handful of small molecules that antagonize the action of the "universal" autoinducer, Al-2, have been reported. The biological basis of antagonism, as well as the targets for these select few Al-2 antagonists, have not been clearly defined. We have developed C-1 alkyl analogs of Al-2 that quench the OS response in multiple bacterial species simultaneously. We also demonstrate the biological basis for this action. Like Al-2, the analogs are activated by the bacterial kinase, LsrK, and modulate Al-2 specific gene transcription through the transcriptional regulator, LsrR. Interestingly, addition of a single carbon to the C1-alkyl chain of the analog plays a crucial role in determining the effect of the analog on the QS response. While an ethyl modified analog is an agonist, propyl becomes an antagonist of the QS circuit. In a trispecies synthetic ecosystem comprised of E. coli, S. typhimurium, and V. harveyi we discovered both cross-species and species-specific anti-Al-2 QS activities. Our results suggest entirely new modalities for interrupting or tailoring the network of communication among bacteria.
• Barltrop et al., Journal of the Chemical Society, 1959, p. 1423,1428
  作者：Barltrop et al.

  DOI：——

  日期：——