枸橼酸铋钾

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 枸橼酸铋钾
• 中文别名: 枸橼酸钾铋
• 英文名称: Pentapotassium;2-[2-[[5-(carboxylatomethyl)-5-oxido-4,7-dioxo-1,3,2-dioxabismepan-2-yl]oxy]-2-oxoethyl]-2-oxidobutanedioate
• 英文别名: pentapotassium;2-[2-[[5-(carboxylatomethyl)-5-oxido-4,7-dioxo-1,3,2-dioxabismepan-2-yl]oxy]-2-oxoethyl]-2-oxidobutanedioate
• 化学式: C12H8BiK5O14
• 分子量: 780.65
• InChiKey: YDDTTXDPCSCLKY-UHFFFAOYSA-H

计算性质

• 辛醇/水分配系数(LogP)：
  -27.13
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  287
• 氢给体数：
  0
• 氢受体数：
  14

ADMET

毒理性

• 蛋白质结合

大于百分之九十

>90%

来源:DrugBank

吸收、分配和排泄

• 吸收

服用胶态次枸橼酸铋（含铋214毫克）后，平均峰值全血铋水平超过50毫克/升，发生在30分钟时。然而，在服用亚硝酸盐铋（含铋205毫克）后，没有证据表明铋被吸收进入血液，尽管有三名志愿者在服用胶态次枸橼酸铋一周后服用亚硝酸盐铋，其血铋基线水平仍然升高。在服用胶态次枸橼酸铋45分钟后，所有五名志愿者的平均血浆水平也进行了评估，与血液水平47.6微克/升相比，血浆水平为79.76微克/升。

The mean peak whole-blood bismuth level after ingestion of colloidal bismuth subcitrate (214 mg bismuth) was more than 50 mg/liter and occurred at 30 minutes. After ingestion of bismuth subnitrate (205 mg bismuth), however, there was no evidence of bismuth absorption into blood, although in three of the volunteers who took bismuth subnitrate a week after colloidal bismuth subcitrate, baseline levels of blood bismuth were still elevated. Forty-five minutes after taking colloidal bismuth subcitrate, mean plasma levels for all five volunteers were also assessed and were 79.76 microg/liter as compared to blood levels of 47.6 microg/liter.

来源:DrugBank

吸收、分配和排泄

• 消除途径

消除铋主要通过尿液和胆汁途径。

Elimination of bismuth is primarily through urinary and biliary routes.

来源:DrugBank

吸收、分配和排泄

• 清除

肾脏消除速率在治疗停止后2周似乎达到稳态，停止后6周的消除速率相似。停药后头两周内，平均尿排泄率为2.6%，每日排泄量（尿药浓度24至250 mcg/mL），这表明组织积累和缓慢消除。

The rate of renal elimination appears to reach steady state 2 weeks after treatment discontinuation with similar rates of elimination at 6 weeks after discontinuation. The average urinary elimination of bismuth is 2.6% per day in the first two weeks after discontinuation (urine drug concentrations 24 to 250 mcg/mL) suggesting tissue accumulation and slow elimination.

来源:DrugBank