s-Nitroso-n-valerylpenicillamine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: s-Nitroso-n-valerylpenicillamine
• 英文别名: (2R)-3-methyl-3-nitrososulfanyl-2-(pentanoylamino)butanoic acid
• 化学式: C₁₀H₁₈N₂O₄S
• 分子量: 262.33
• InChiKey: QCRZCAKMRYXQNT-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  121
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• THERAPEUTIC COMBINATIONS
  申请人：SUPERSALUS, INC.

  公开号：US20200253926A1

  公开（公告）日：2020-08-13

  Methods of treatment include administering effective amounts of a nitrogen oxide (NO) donor (such as nicorandil) and a hydrogen sulfide (H 2 S) releasing agent (such as zofenopril) to a subject in need thereof. In various embodiments, the H 2 S releasing agent is administered in an amount that is effective to enhance the therapeutic efficacy of the NO donor. Coformulations of the H 2 S releasing agent and the NO donor are provided that are suitable for treating a number of conditions. In various embodiments, treatments for conditions such as chronic kidney disease, Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, familial dilated cardiomyopathy and/or idiopathic dilated cardiomyopathy are provided.

  治疗方法包括向需要的对象施用有效量的一氧化氮（NO）供体（如尼可拉地尔）和硫化氢（H2S）释放剂（如左非诺普利）。在各种实施方式中，以有效量施用H2S释放剂以增强NO供体的治疗功效。提供了H2S释放剂和NO供体的联合制剂，适用于治疗多种疾病。在各种实施方式中，提供了治疗慢性肾病、杜兴氏肌肉萎缩症、贝克氏肌肉萎缩症、家族性扩张型心肌病和/或特发性扩张型心肌病等疾病的方法。
• Methods and compositions for regulating biofilm development
  申请人：Environmental Biotechnology CRC Pty Limited

  公开号：EP2351828A1

  公开（公告）日：2011-08-03

  The present invention relates to methods for promoting dispersal of, or preventing formation of microbial biofilms, comprising: exposing a biofilm to an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent; treating a surface or medium susceptible to biofilm formation with an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent; incorporating an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent in a surface or medium susceptible to biofilm formation; or inducing the accumulation of one or more reactive oxygen or nitrogen species within microorganisms within said biofilm or capable of forming a biofilm. The invention also relates to methods for maintaining or enhancing or maintaining and enhancing the functioning of a biofilm, comprising exposing a biofilm to at least one nitric oxide scavenger, at least one antioxidant or at least one nitric oxide scavenger and at least one antioxidant. The invention also relates to compositions for promoting dispersal of, or preventing formation of microbial biofilms, or for maintaining or enhancing or maintaining and enhancing the functioning of microbial biofilms.

  本发明涉及促进微生物生物膜的分散或防止其形成的方法，包括将生物膜暴露于有效量的一氧化氮或至少一种一氧化氮产生剂或释放剂；用有效量的一氧化氮或至少一种一氧化氮产生剂或释放剂处理易形成生物膜的表面或介质；在易形成生物膜的表面或介质中加入有效量的一氧化氮或至少一种一氧化氮产生剂或释放剂；或诱导所述生物膜内或能形成生物膜的微生物体内一种或多种活性氧或氮物种的积累。本发明还涉及维持或增强或维持和增强生物膜功能的方法，包括将生物膜暴露于至少一种一氧化氮清除剂、至少一种抗氧化剂或至少一种一氧化氮清除剂和至少一种抗氧化剂。本发明还涉及用于促进微生物生物膜的分散或防止微生物生物膜的形成，或用于维持或增强或维持和增强微生物生物膜功能的组合物。
• USE OF NITRIC OXIDE OR NITRIC OXIDE DONOR FOR INDUCING THE PRODUCTION OF TRIACYLGLYCEROLS IN MICROALGAE
  申请人：COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES

  公开号：EP3199620A1

  公开（公告）日：2017-08-02

  The invention relates to a method for triggering triacylglycerols (TAG) accumulation in microalgae comprising the step of contacting a source of exogenous nitroxide (NO) with said microalgae in their growth medium.

  本发明涉及一种在微藻类中引发三酰甘油（TAG）积累的方法，包括将外源亚硝基氧化物（NO）与生长培养基中的微藻类接触的步骤。
• Methods and systems of treating wounds
  申请人：The Regents of the University of California

  公开号：US10272096B2

  公开（公告）日：2019-04-30

  The invention generally relates to methods for treating and/or reducing the severity of a wound in a subject. Provided are wound therapies combining low level light therapy (LLLT) and a nitric oxide (NO) donor to treat and/or reduce the severity of the wound. The LLLT and NO donor may be administered concurrently or sequentially. Also provided are wound treatment systems and kits including a light source and a NO donor, which are administered to a wounded subject. Further provided are pharmaceutical compositions that comprise a NO donor and are formulated to be administered in conjunction with LLLT.

  本发明一般涉及治疗和/或减轻受试者伤口严重程度的方法。本发明提供了结合低强度光疗法（LLLT）和一氧化氮（NO）供体的伤口疗法，用于治疗和/或减轻伤口的严重程度。低强度光疗法和一氧化氮供体可同时或依次施用。此外，还提供了包括光源和一氧化氮供体在内的伤口治疗系统和套件，可对受伤者施用。此外，还提供了包含 NO 供体的药物组合物，其配方可与 LLLT 一起使用。
• Use of nitric oxide or nitric oxide donor for inducing the production of triacylglycerols in microalgae
  申请人：Commissariat A L'energie Atomique Et Aux Energies Alternatives

  公开号：US10975399B2

  公开（公告）日：2021-04-13

  The invention relates to a method for triggering triacylglycerols (TAG) accumulation in microalgae comprising the step of contacting a source of exogenous nitroxide (NO) with said microalgae in their growth medium.

  本发明涉及一种引发微藻类中三酰甘油（TAG）积累的方法，包括将外源亚硝基氧化物（NO）与生长培养基中的微藻类接触的步骤。