1-(4-甲氧基苯氧基)-3-哌嗪-1-基-2-丙醇 | 75375-23-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-(4-甲氧基苯氧基)-3-哌嗪-1-基-2-丙醇
• 英文名称: N-[3-(4-methoxyphenoxy)-2-hydroxypropyl]-piperazine
• 英文别名: 1-[3-(4-methoxyphenoxy)-2-hydroxypropyl]piperazine；1-(4-methoxy-phenoxy)-3-piperazin-1-yl-propan-2-ol；3-(4-methoxyphenoxy)-1-piperazinylpropan-2-ol；1-(4-methoxyphenoxy)-3-piperazin-1-ylpropan-2-ol
• CAS: 75375-23-4
• 化学式: C₁₄H₂₂N₂O₃
• 分子量: 266.34
• InChiKey: LOHBUGASUBABIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  54
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2933599090

反应信息

• 作为产物：
  描述：

  2,3-环氧丙基-4-甲氧基苯基醚 生成 1-(4-甲氧基苯氧基)-3-哌嗪-1-基-2-丙醇
  参考文献：
  名称：

  Carbamyl piperazine derivatives

  摘要：

  4-(3-芳氧基-2-羟基丙基)哌嗪，在1位含有一个氨基甲酰基、N-烷基或N,N-二烷基氨基甲酰基的化合物，是β-肾上腺素能阻滞剂。一个典型的例子是1-氨基甲酰-4-(3-苯氧基-2-羟基丙基)哌嗪。

  公开号：

  US04269838A1

文献信息

• Substituted heterocyclic compounds
  申请人：——

  公开号：US20030176447A1

  公开（公告）日：2003-09-18

  Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes, and for increasing HDL plasma levels in mammals.

  揭示了一种新颖的杂环衍生物，用于治疗各种疾病状态，特别是心血管疾病，如心房和心室心律失常、间歇性跛行、普林兹梅塔（变异）心绞痛、稳定和不稳定心绞痛、运动诱发性心绞痛、充血性心力衰竭和心肌梗死。这些化合物还可用于治疗糖尿病，并可增加哺乳动物的高密度脂蛋白血浆水平。
• [EN] SUBSTITUTED PIPERAZINE COMPOUNDS AND THEIR USE AS FATTY ACID OXIDATION INHIBITORS<br/>[FR] COMPOSES DE PIPERAZINE SUBSTITUES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE L'OXYDATION D'ACIDES GRAS
  申请人：CV THERAPEUTICS INC

  公开号：WO2003008411A1

  公开（公告）日：2003-01-30

  Disclosed are novel heterocyclic derivatives of the formula (I), wherein amongst others R?1, R2, R3, R4, R5, R6, R7, and R8¿ are hydrogen; T is oxygen, sulfur, or NR11, in which R11 is hydrogen or lower alkyl; V is N<, -CH<, or N-CH<; X1 is hydrogen, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; X2 is optionally substituted aryl or optionally substituted heteroaryl; Y is optionally substituted monocyclic heteroarylenyl; and Z?1 and Z2¿ are independently optionally substituted alkylene or 1-4 carbon atoms. The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes, and for increasing HDL plasma levels in mammals.

  本发明涉及一种新型杂环衍生物的公开式（I），其中，R1、R2、R3、R4、R5、R6、R7和R8中的一些是氢；T为氧、硫或NR11，其中R11为氢或低碳基；V为N<、-CH<或N-CH<；X1为氢、可选取代的低碳基、可选取代的环烷基、可选取代的芳基或可选取代的杂环芳基；X2为可选取代的芳基或可选取代的杂环芳基；Y为可选取代的单环杂芳基；Z1和Z2独立地为可选取代的烷基或1-4碳原子。该化合物可用于治疗各种疾病状态，特别是心血管疾病，如心房和心室心律失常、间歇性跛行、普林兹梅塔尔（变异型）心绞痛、稳定和不稳定性心绞痛、运动诱发性心绞痛、充血性心力衰竭和心肌梗死。该化合物还可用于治疗糖尿病，并可提高哺乳动物的高密度脂蛋白血浆水平。
• Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0126449A1

  公开（公告）日：1984-11-28

  Novel compounds of the general formula and the pharmaceutically acceptable esters and acid addition salts thereof, wherein: R1, R2, R3, R4, and R5 are each independently hydrogen, lower alkyl, lower alkoxy, cyano, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, N-optionally substituted alkylamido, except that when R1 is methyl, R4 is not methyl; or R2 and R3 together form -OCH2O-; R6, R7, R8, R9 and R10 are each independently hydrogen, lower acyl, aminocarbonyl-methyl, arylcyano, lower alkyl, lower alkoxy, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, di-lower alkyl amino; or R6 and R7 together form -CH = CH-CH = CH-; R7 and R8 together form -OCH2O -; R11 and R12 are each independently hydrogen or lower alkyl; and W is oxygen or sulfur. These cardioselective compounds have calcium entry blockade properties and therefore are useful in therapy in the treatment of cardiovascular diseases, including arrhythmias, variant and exercise induced angina and myocardial infarction.

  通式为 及其药学上可接受的酯和酸加成盐，其中 R1、R2、R3、R4 和 R5 各自独立地为氢、低级烷基、低级烷氧基、氰基、三氟甲基、卤代、低级烷硫基、低级烷基亚磺酰基、低级烷基磺酰基、N-可选取代的烷基氨基，但当 R1 为甲基时，R4 不是甲基；或 R2 和 R3 共同形成 -OCH2O-； R6、R7、R8、R9 和 R10 各自独立地为氢、低级酰基、氨基羰基甲基、芳基氰基、低级烷基、低级烷氧基、三氟甲基、卤代、低级烷硫基、低级烷基亚磺酰基、低级烷基磺酰基、二低级烷基氨基；或 R6 和 R7 共同形成 -CH = CH-CH = CH-； R7 和 R8 共同形成 -OCH2O -； R11 和 R12 各自独立地为氢或低级烷基；以及 W 是氧或硫。 这些心脏选择性化合物具有钙离子进入阻断特性，因此可用于治疗心血管疾病，包括心律失常、变异型和运动诱发的心绞痛和心肌梗塞。
• Substituted piperazine compounds and their use as fatty acid oxidation inhibitors
  申请人：CV THERAPEUTICS, INC.

  公开号：EP1806346A1

  公开（公告）日：2007-07-11

  Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.

  所公开的新型杂环衍生物可用于治疗各种疾病，尤其是心血管疾病，如房性和室性心律失常、间歇性跛行、普林兹梅塔尔（变异型）心绞痛、稳定型和不稳定型心绞痛、运动诱发心绞痛、充血性心脏病和心肌梗塞。这些化合物还可用于治疗糖尿病。
• Azomethine dye precursor, image-forming material, and image-forming method
  申请人：——

  公开号：US20010019806A1

  公开（公告）日：2001-09-06

  The present invention related to an azomethine dye precursor represented by the following general formula (1) and the image-forming material and image-forming method using the azomethine dye precursor: wherein Ar represents an aryl group or a heterocyclic group which may each have a substituent; X represents a bivalent group linking a carbon atom and a nitrogen atom; and Cp represent a coupler residue which may or may not form a ring. General formula 1

  本发明涉及由以下通式（1）表示的偶氮亚甲基染料前体以及使用该偶氮亚甲基染料前体的成象材料和成象方法： 其中 Ar 代表芳基或杂环基，它们可以各自具有一个取代基；X 代表连接碳原子和氮原子的二价基团；Cp 代表耦合剂残基，它可以形成环，也可以不形成环。 通式 1