1-(4-碘苯)-5-(4-硝基苯基)-3-苯基甲臢 | 7781-49-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(4-碘苯)-5-(4-硝基苯基)-3-苯基甲臢
• 中文别名: 5-(4-碘苯)-1-(4-硝基苯)-3-苯基甲；INT甲臢；碘硝基四唑甲臢；甲臜；INT甲臜
• 英文名称: INT-formazan
• 英文别名: N-(4-iodophenyl)imino-N'-(4-nitroanilino)benzenecarboximidamide
• CAS: 7781-49-9
• 化学式: C₁₉H₁₄IN₅O₂
• 分子量: 471.257
• InChiKey: FVFWUNAWQMROIF-UHFFFAOYSA-N

物化性质

• 熔点：
  187 °C (dec.)(lit.)
• 沸点：
  564.9±60.0 °C(Predicted)
• 密度：
  1.59±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.76
• 重原子数：
  27.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.25
• 氢给体数：
  1.0
• 氢受体数：
  5.0

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S22,S24/25,S36/37
• 危险类别码：
  R43
• 海关编码：
  2928000090

反应信息

• 作为产物：
  描述：

  2-(4-碘苯基)-3-(4-硝基苯基)-5-苯基氯化四唑 在 potassium superoxide 、 C₁₁H₁₅CuNO₅ 作用下， 以 二甲基亚砜 为溶剂， 生成 1-(4-碘苯)-5-(4-硝基苯基)-3-苯基甲臢
  参考文献：
  名称：

  含五元，六元和不寻常的七元环 的铜（ii）Schiff碱配合物的合成，晶体结构和抗自由基作用†

  摘要：

  单核铜（II）配合物[Cu（SAIB）（H 2 O）2 ]（1），[Cu（SBAIB）（H 2 O）2 ]·H 2 O（2）和描述了[Cu（SGABA）（H 2 O）2 ]（3）。席夫碱配体ħ 2 SAIB，H 2 SBAIB和H 2 SGABA螯合物的铜（II）离子在ø，Ñ，ö三齿方式。最终络合物的方锥几何由两个完成水配体。据报道，在一组铜（II）N-水杨基-氨基酸酸酯中形成了一个不寻常的七元环。通过抗自由基活性测定评估了化合物1-3。

  DOI：

  10.1039/c0dt00901f

文献信息

• METHOD OF ASSAY BY OXIDATION-REDUCTION REACTION WITH FORMAZAN
  申请人：ARKRAY, Inc.

  公开号：EP1515143A1

  公开（公告）日：2005-03-16

  The present invention provides a highly reliable method of measuring an analyte in a sample using a redox reaction. In this method, a formazan compound is added to a sample prior to a redox reaction so as to eliminate the influence of any reducing substance in the sample. Thereafter, a reducing substance or an oxidizing substance derived from the analyte is formed, and the amount of the formed substance is measured by the redox reaction. The amount of the analyte is determined from the amount of the formed substance thus measured. As the formazan compound, for example, 1-(4-iodophenyl)-3-(2,4-disulfophenyl)-5-(2,4-dinitrophenyl) formazan can be used.

  本发明提供了一种利用氧化还原反应测量样品中分析物的高度可靠的方法。在该方法中，在氧化还原反应之前向样品中加入一种甲臢化合物，以消除样品中任何还原性物质的影响。之后，形成一种还原性物质或由分析物衍生的氧化性物质，并通过氧化还原反应测量所形成物质的量。分析物的量可根据由此测得的生成物质的量来确定。例如，可以使用 1-（4-碘苯基）-3-（2,4-二磺酸苯基）-5-（2,4-二硝基苯基）甲臢作为甲臢化合物。
• Gradinaru, Daniela; Margina, Denisa; Borsa, Claudia, Revue Roumaine de Chimie, 2009, vol. 54, # 9, p. 761 - 766
  作者：Gradinaru, Daniela、Margina, Denisa、Borsa, Claudia

  DOI：——

  日期：——
• Method of assay by oxidation-reduction reaction with formazan
  申请人：Yonehara Satoshi

  公开号：US20050202399A1

  公开（公告）日：2005-09-15

  The present invention provides a highly reliable method of measuring an analyte in a sample using a redox reaction. In this method, a formazan compound is added to a sample prior to a redox reaction so as to eliminate the influence of any reducing substance in the sample. Thereafter, a reducing substance or an oxidizing substance derived from the analyte is formed, and the amount of the formed substance is measured by the redox reaction. The amount of the analyte is determined from the amount of the formed substance thus measured. As the formazan compound, for example, 1-(4-iodophenyl)-3-(2,4-disulfophenyl)-5-(2,4-dinitrophenyl) formazan can be used.
• TESTING SYSTEM FOR DETERMINING HYPOXIA INDUCED CELLULAR DAMAGE
  申请人：Karlsson Mathias

  公开号：US20130052675A1

  公开（公告）日：2013-02-28

  The present invention relates to a testing system for assessing hypoxia induced cellular damage in a mammal including human, comprising a disposable device having a sample inlet and a collection chamber separated by a separation device wherein the collection chamber is connected to at least two, a first and a second, visible detection compartments, whereof at least one is arranged with chemical means for direct visual detection, said first detection compartment being arranged to determine whether level of hemoglobin (Hb) in a sample of body fluid taken from said mammal exceeds a predetermined threshold value, and said second detection compartment being arranged to evaluate level of total amount of lactate dehydrogenase (LDH) in said sample.
• ARTICLES AND METHODS FOR THE DETECTION AND QUANTIFICATION OF ULTRAVIOLET LIGHT
  申请人：Sharavara Andrey

  公开号：US20140038305A1

  公开（公告）日：2014-02-06

  Formulations, articles and methods for the detection and/or qualification of ultraviolet light. A chemical formulation containing a tetrazolium or formazan complex is used to make a UV sensitive compound. The formulation is used to form a chemical indicator comprising a substrate with the formulation impregnated on or in the substrate. The substrate may be any suitable material and may be coated, uncoated, or laminated. The formulation may be coated on or inserted into a substrate and will form a UV detecting indicator when applied thereto. Depending upon its composition, the formulation will undergo a color change on exposure to different types of ultraviolet radiation, such as UVA, UVB or UVC, and the color change can be correlated to the length of exposure. The indicator can be used to detect and evaluate exposure to ultraviolet light in a variety of settings depending on the specifics of the formulation.