1-(4-羟基苯基)-2-甲基-2-丙烯-1-酮 | 60644-65-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(4-羟基苯基)-2-甲基-2-丙烯-1-酮
• 英文名称: 2-(p-hydroxyphenyl)-2-methyl-2-propen-1-one
• 英文别名: 1-(4-hydroxyphenyl)-2-methylprop-2-en-1-one；1-(4-hydroxyphenyl)-2-methyl-2-propen-1-one；1-(4-hydroxy-phenyl)-2-methyl-propenone；1-(4-Hydroxy-phenyl)-2-methyl-propenon
• CAS: 60644-65-7
• 化学式: C₁₀H₁₀O₂
• 分子量: 162.188
• InChiKey: JHEHMORCLSVNKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-羟基苯基)-2-甲基-2-丙烯-1-酮 在 potassium carbonate 、 potassium iodide 作用下， 以 丁酮 为溶剂， 反应 96.0h， 生成 Ethyl 4-[3-[4-(2-methylprop-2-enoyl)phenoxy]propyl]piperazine-1-carboxylate
  参考文献：
  名称：

  Structure–activity relationships of non-imidazole H3 receptor ligands. Part 1

  摘要：

  SAR studies for novel non-imidazole containing H-3 receptor antagonists with high potency and selectivity for rat H-3 receptors are described. A high throughput screening lead, A-923, was further elaborated in a systematic manner to clarify a pharmacophore for this class of aryloxyalkyl piperazine based compounds. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00309-8
• 作为产物：
  描述：

  4-羟基苯丙酮 在 盐酸 、 sodium hydroxide 、 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 16.5h， 生成 1-(4-羟基苯基)-2-甲基-2-丙烯-1-酮
  参考文献：
  名称：

  Hydroxymethylation of Propiophenones in Aqueous Medium: A New Route to 1-Aryl-2-methyl-2-propen-1-ones

  摘要：

  DOI：

  10.1055/s-1984-30837

文献信息

• Thermal Retro-Aldol Reaction Using Fluorous Ether F-626 as a Reaction Medium
  作者：Ilhyong Ryu、Takahide Fukuyama、Takuji Kawamoto、Takahiro Okamura、Aurelien Denichoux

  DOI：10.1055/s-0030-1258501

  日期：2010.9

  A high-boiling, fluorous-organic hybrid ether, F-626, was tested for use in thermal retro-aldol reactions and found to be an excellent reaction medium in view of the ease of separation from the product by fluorous/organic biphasic treatment. The recovered F-626 can be readily reused for subsequent runs.

  高沸点氟有机杂化醚F-626被测试用于热逆羟醛反应，并发现它是一种优秀的反应介质，因为可以通过氟/有机两相处理轻松地从产物中分离出来。回收的F-626可以方便地重复用于后续的反应批次。
• Reinvestigation of the Reaction of 3-Hydroxy-2-methyl-1-aryl-1-propanones and Related Compounds with Hydrazine and Carboxylic Acids
  作者：Giorgio Cignarella、Daniela Barlocco、Maria Michela Curzu、Gérard Aimé Pinna

  DOI：10.1055/s-1989-27242

  日期：——

  The reaction between the title compounds and hydrazine hydrate in an appropriate carboxylic acid gave 1-acyl/aroyl-3-aryl-4-methyl-4,5-dihydropyrazoles 9, instead of 2,5,6-trisubstituted 6,7-dihydro-1,3,4-oxadiazepines as previously reported. Evidence is presented for the attribution of the correct structure and for the reaction mechanisms involved.

  标题化合物与水合肼在适当的羧酸中发生反应，生成了 1-酰基/芳酰基-3-芳基-4-甲基-4,5-二氢吡唑 9，而不是以前报告的 2,5,6-三取代的 6,7-二氢-1,3,4-恶二氮杂卓。文中提出了正确结构的归属和相关反应机制的证据。
• Building Material
  申请人：KUREHA CHEMICAL INDUSTRY COMPANY, LIMITED

  公开号：US20040204600A1

  公开（公告）日：2004-10-14

  A building material is formed from a specific composition containing a phosphoric ester compound represented by the following formulae (8)-c and (8)-d and copper ions, in a resin plate.

  一种建筑材料由特定组成成分形成，该组成成分包含以下化学式(8)-c和(8)-d所代表的磷酸酯化合物和铜离子，在树脂板中。
• Photochemical Desaturation and Epoxidation with Oxygen by Sequential Flavin Catalysis
  作者：Alexandra Walter、Wolfgang Eisenreich、Golo Storch

  DOI：10.1002/anie.202310634

  日期：2023.10.16

  flavoenzymes mediate mechanistically unrelated transformations such as desaturations and epoxidations with oxygen from air. We disclose the combination of both activities in a sequential fashion using molecular flavin catalysts in the organic laboratory. Our protocol consists of initial photochemical desaturation of silyl enol ethers and subsequent α,β-epoxyketone formation with molecular oxygen.

  在自然界中，黄素酶介导机械上不相关的转化，例如与空气中的氧气的去饱和和环氧化。我们公开了在有机实验室中使用分子黄素催化剂以连续方式组合这两种活性。我们的方案包括甲硅烷基烯醇醚的初始光化学去饱和和随后与分子氧形成 α,β-环氧酮。
• NEAR-INFRARED-ABSORBING COMPOSITION AND OPTICAL MATERIAL
  申请人：KUREHA KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP1277821A1

  公开（公告）日：2003-01-22

  A near infrared absorptive composition of the present invention contains phosphate compounds represented by Formula (8)-c and Formula (8)-d below; and copper ions. An optical material of the present invention is a material wherein the near infrared absorptive composition is mixed in a resin.

  本发明的近红外吸收性组合物含有下式（8）-c 和式（8）-d 所代表的磷酸盐化合物； 和铜离子。本发明的光学材料是一种将近红外线吸收剂组合物混合在树脂中的材料。