ethyl (2R)-4,4,4-trifluoro-2-methyl-3-oxobutanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: ethyl (2R)-4,4,4-trifluoro-2-methyl-3-oxobutanoate
• 化学式: C₇H₉F₃O₃
• 分子量: 198.14
• InChiKey: YLRGPBKEZVHOAW-SCSAIBSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• HETEROCYCLIC COMPOUNDS AS DELTA-5 DESATURASE INHIBITORS AND METHODS OF USE
  申请人：Amgen Inc.

  公开号：US20210171529A1

  公开（公告）日：2021-06-10

  The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5D”). The compounds have a general Formula 1: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.