1-(5-溴-2-吡啶)-1,4-二氮杂烷 | 855787-68-7

• 物质功能分类: 医药中间体 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1-(5-溴-2-吡啶)-1,4-二氮杂烷
• 英文名称: 1-(5-bromo-pyridin-2-yl)-[1,4]diazepane
• 英文别名: 1-(5-bromo-pyridin-2-yl)-1,4-diazepane；1-(5-Bromopyridin-2-yl)-1,4-diazepane
• CAS: 855787-68-7
• 化学式: C₁₀H₁₄BrN₃
• 分子量: 256.145
• InChiKey: HGPQRNSDOVULHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  28.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(5-溴-2-吡啶)-1,4-二氮杂烷 、 4-nitrophenyl 2-(methylamino)-2-oxoethyl carbonate 在 silica gel 、 乙酸乙酯 、 环己烷 、 二氯甲烷 、 甲醇 、 异丙醚 作用下， 以obtained in step 11.2的产率得到2-(methylamino)-2-oxoethyl 4-(5-bromo-pyridin-2-yl)-1,4-diazepane-1-carboxylate
  参考文献：
  名称：

  DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME

  摘要：

  本发明涉及具有一般式（I）的化合物：其中m、R1和R2如本文所定义。本发明还涉及化合物在治疗学中的应用。更具体地说，本发明的化合物是FAAH酶的抑制剂，因此可用于治疗与FAAH酶相关的各种疾病，包括但不限于疼痛、进食障碍、神经和精神病理等疾病。

  公开号：

  US20100137329A1
• 作为产物：
  描述：

  tert-butyl 4-(5-bromopyridine-2-yl)-1,4-diazepane-1-carboxylate 在 盐酸 、 乙醇 、 异丙醇 、 氨 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 水 为溶剂， 反应 3.0h， 生成 1-(5-溴-2-吡啶)-1,4-二氮杂烷
  参考文献：
  名称：

  Derivatives of 1-piperazine-and 1-homopiperazine-carboxylates, preparation method thereof and use of same as inhibitors of the FAAH enzyme

  摘要：

  这项发明涉及具有一般式(I)的化合物：其中m，R1和R2如本文所定义。该发明还涉及该化合物在治疗中的应用。更具体地说，该发明的化合物是FAAH酶的抑制剂，因此可用于治疗与FAAH酶相关的各种疾病，包括但不限于疼痛、进食障碍、神经和精神病理等疾病。

  公开号：

  US20060293310A1

文献信息

• BICYCLIC NITROIMIDAZOLE-SUBSTITUTED PHENYL OXAZOLIDINONES
  申请人：Ding Charles Z.

  公开号：US20090281088A1

  公开（公告）日：2009-11-12

  The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.

  本发明提供了一系列双环硝基咪唑取代的苯基噁唑烷酮，其中双环硝基咪唑药效团与苯基噁唑烷酮共价键合，它们的制药组合物以及用于预防和治疗细菌感染的组合物的使用方法。这些双环硝基咪唑取代的苯基噁唑烷酮对野生型和耐药菌株具有惊人的抗菌活性，因此对于预防、控制和治疗由这些病原体引起的许多人类和兽医细菌感染是有用的，如结核分枝杆菌。
• DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME
  申请人：ABOUABDELLAH Ahmed

  公开号：US20100137329A1

  公开（公告）日：2010-06-03

  The invention relates to a compound having general formula (I): Wherein m, R 1 and R 2 are as defined herein. The invention also relates to the use of the compound in therapeutics. More specifically, the compounds of the invention are inhibitors of the FAAH enzyme, and therefore, can be used for the treatment of various disorders associated with FAAH enzyme, which include in a non-limiting manner, pain, eating disorders, neurological and psychiatric pathologies, among other disorders.

  本发明涉及具有一般式（I）的化合物：其中m、R1和R2如本文所定义。本发明还涉及化合物在治疗学中的应用。更具体地说，本发明的化合物是FAAH酶的抑制剂，因此可用于治疗与FAAH酶相关的各种疾病，包括但不限于疼痛、进食障碍、神经和精神病理等疾病。
• Derivatives of 1-piperazine- and 1-homopiperazine-carboxylates, preparation method thereof and use of same as inhibitors of the FAAH enzyme
  申请人：Sanofi-Aventis

  公开号：US08114866B2

  公开（公告）日：2012-02-14

  The invention relates to a compound having general formula (I): Wherein m, R1 and R2 are as defined herein. The invention also relates to the use of the compound in therapeutics. More specifically, the compounds of the invention are inhibitors of the FAAH enzyme, and therefore, can be used for the treatment of various disorders associated with FAAH enzyme, which include in a non-limiting manner, pain, eating disorders, neurological and psychiatric pathologies, among other disorders.

  本发明涉及具有一般式（I）的化合物：其中m，R1和R2如本文所定义。本发明还涉及该化合物在治疗中的应用。更具体地说，本发明的化合物是FAAH酶的抑制剂，因此可用于治疗与FAAH酶相关的各种疾病，包括但不限于疼痛、进食障碍、神经和精神病理等疾病。
• Bicyclic nitroimidazole-substituted phenyl oxazolidinones
  申请人：Global Alliance for TB Drug Development

  公开号：US07666864B2

  公开（公告）日：2010-02-23

  The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.

  本发明提供了一系列双环硝基咪唑取代的苯基噁唑烷酮，其中双环硝基咪唑药效团与苯基噁唑烷酮共价键合，它们的制药组合物以及用于预防和治疗细菌感染的组合物的使用方法。这些双环硝基咪唑取代的苯基噁唑烷酮对野生型和耐药菌株具有惊人的抗菌活性，因此对于预防、控制和治疗由这些病原体引起的多种人类和兽医细菌感染，如结核分枝杆菌等，非常有用。
• BIS(5-ARYL-2-PYRIDYL) DERIVATIVE
  申请人：Kowa Co., Ltd.

  公开号：EP1403250A1

  公开（公告）日：2004-03-31

  Disclosed are bis(5-aryl-2-pyridyl) derivatives represented by the following formula (1) or salts thereof: wherein A represents a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group, and X represents a group selected from the following formulas (2) to (5): wherein in the formula (2), m stands for an integer of 1 or 2; in the formula (3), n stands for an integer of 1 to 6; in the formula (4), R represents a hydrogen atom or a lower alkyl group and p stands for an integer of 1 to 6. Medicines, IgE antibody production inhibitors, medicinal compositions and treatment methods for allergic immune diseases, all of which make use of the bis(5-aryl-2-pyridyl) derivatives or salts thereof, are also disclosed.

  本发明公开了由下式（1）代表的双（5-芳基-2-吡啶基）衍生物或其盐： 其中 A 代表取代或未取代的芳香烃基团或取代或未取代的芳香杂环基团，X 代表选自下式 (2) 至 (5) 的基团： 其中，在式 (2) 中，m 代表 1 或 2 的整数；在式 (3) 中，n 代表 1 至 6 的整数；在式 (4) 中，R 代表氢原子或低级烷基，p 代表 1 至 6 的整数。此外，还公开了利用双（5-芳基-2-吡啶基）衍生物或其盐的药物、IgE 抗体产生抑制剂、药物组合物和过敏性免疫疾病的治疗方法。