1-(呋喃-2-基)戊-2-炔-1,4-二醇 | 946401-60-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 中文名称: 1-(呋喃-2-基)戊-2-炔-1,4-二醇
• 英文名称: 1-(furan-2-yl)pent-2-yne-1,4-diol
• 英文别名: 1-(2-furyl)pent-2-yne-1,4-diol
• CAS: 946401-60-1
• 化学式: C₉H₁₀O₃
• 分子量: 166.177
• InChiKey: QHGWDCCCRSSXOW-UHFFFAOYSA-N

物化性质

• 熔点：
  67-69 °C
• 沸点：
  317.3±37.0 °C(Predicted)
• 密度：
  1.240±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  53.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(呋喃-2-基)戊-2-炔-1,4-二醇 在 苯甲酸 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以81%的产率得到(furyl-2')-2 methyl-5 furanne
  参考文献：
  名称：

  2,5-Disubstituted furans from 1,4-alkynediols

  摘要：

  1-4-Alkynediols serve as readily available starting materials for isomerisation to 1,4-diketones, which can be converted in situ into the corresponding furans by acid-catalysed dehydration. A range of 2,5-disubstituted furans was prepared using the ruthenium-based catalyst Ru(PPh3)(3)(CO)H-2 with Xantphos at 1 mol % loading. (C) 2007 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2007.05.069
• 作为产物：
  描述：

  糠醛 、 3-丁炔-2-醇 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以38%的产率得到1-(呋喃-2-基)戊-2-炔-1,4-二醇
  参考文献：
  名称：

  2,5-Disubstituted furans from 1,4-alkynediols

  摘要：

  1-4-Alkynediols serve as readily available starting materials for isomerisation to 1,4-diketones, which can be converted in situ into the corresponding furans by acid-catalysed dehydration. A range of 2,5-disubstituted furans was prepared using the ruthenium-based catalyst Ru(PPh3)(3)(CO)H-2 with Xantphos at 1 mol % loading. (C) 2007 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2007.05.069

文献信息

• Ruthenium-catalysed conversion of 1,4-alkynediols into pyrroles
  作者：Simon J. Pridmore、Paul A. Slatford、Aurélie Daniel、Michael K. Whittlesey、Jonathan M.J. Williams

  DOI：10.1016/j.tetlet.2007.05.070

  日期：2007.7

  Various 1,2,5-substituted pyrroles have been synthesised from 1,4-alkynediols using a ruthenium catalysed isomerisation to give the corresponding 1,4-dicarbonyl compounds, which undergo in situ cyclisation to pyrroles in the presence of amine. (C) 2007 Published by Elsevier Ltd.
• 2,5-Disubstituted furans from 1,4-alkynediols
  作者：Simon J. Pridmore、Paul A. Slatford、Jonathan M.J. Williams

  DOI：10.1016/j.tetlet.2007.05.069

  日期：2007.7

  1-4-Alkynediols serve as readily available starting materials for isomerisation to 1,4-diketones, which can be converted in situ into the corresponding furans by acid-catalysed dehydration. A range of 2,5-disubstituted furans was prepared using the ruthenium-based catalyst Ru(PPh3)(3)(CO)H-2 with Xantphos at 1 mol % loading. (C) 2007 Published by Elsevier Ltd.
• Synthesis of furans, pyrroles and pyridazines by a ruthenium-catalysed isomerisation of alkynediols and in situ cyclisation
  作者：Simon J. Pridmore、Paul A. Slatford、James E. Taylor、Michael K. Whittlesey、Jonathan M.J. Williams

  DOI：10.1016/j.tet.2009.06.108

  日期：2009.10

  Alkyne-1,4-diols are readily available substrates which are isomerised to 1,4-diketones using Ru(PPh3)(3)(CO)H-2/xantphos as a catalyst. In situ cyclisation into furans, pyrroles and pyridazines has been achieved under suitable conditions. (C) 2009 Elsevier Ltd. All rights reserved.