1-(氯甲基)-2-(3-氯丙基)苯 | 65349-63-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(氯甲基)-2-(3-氯丙基)苯
• 英文名称: 1-Chlor-3-(2-chlormethylphenyl)propan
• 英文别名: 2-<γ-Chlor-propyl>-benzylchlorid；3-(2-Chloromethylphenyl)-propyl chloride；2-(3-chloro propyl)-benzyl chloride；1-chloromethyl-2-(3-chloro-propyl)-benzene；1-Chlormethyl-2-(3-chlor-propyl)-benzol；1-(Chloromethyl)-2-(3-chloropropyl)benzene
• CAS: 65349-63-5
• 化学式: C₁₀H₁₂Cl₂
• 分子量: 203.111
• InChiKey: NJOKEOCKKQCATL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-(氯甲基)-2-(3-氯丙基)苯 在 氢氧化钾 、 乙醚 、 硫酸 、 sodium hydride 作用下， 生成 6-oxo-6,7,8,9-tetrahydro-5H-benzocycloheptene-5-carboxylic acid methyl ester
  参考文献：
  名称：

  The Synthesis of Benzcyclohepten-6-one¹

  摘要：

  DOI：

  10.1021/ja01105a009
• 作为产物：
  描述：

  3-[2-(羟基甲基)苯基]-1-丙醇 在 氯化亚砜 、 氯仿 、 N,N-二甲基苯胺 作用下， 生成 1-(氯甲基)-2-(3-氯丙基)苯
  参考文献：
  名称：

  The Synthesis of Benzcyclohepten-6-one¹

  摘要：

  DOI：

  10.1021/ja01105a009

文献信息

• 5,6-Benzo analogues or prostaglandin E
  申请人：Miles Laboratories, Inc.

  公开号：US04096336A1

  公开（公告）日：1978-06-20

  Disclosed are prostaglandin analogues having the structural formula, ##STR1## in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano; M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene; L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine; J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine; W is selected from the group consisting of --CH.sub.2 --CH-- or trans --CH.dbd.C--; T.sub.1 and T.sub.2 are attached to adjacent carbon atoms; T.sub.1 is selected from the group consisting of hydrogen or phenyl, provided T.sub.1 is phenyl only if T.sub.2 is lower alkyl; T.sub.2 is selected from the group consisting of n-pentyl or lower alkyl, provided T.sub.2 is lower alkyl only if T.sub.1 is phenyl; Or T.sub.1 and T.sub.2 are joined together to form an alkylene group of 4 or 6 carbon atoms. Also disclosed are methods for preparing such prostaglandin analogues.

  本文披露了具有下列结构式的前列腺素类似物：其中：T选自羧基、烷氧羰基或氰基组成的群；M选自羰基、R-羟甲亚甲基或S-羟甲亚甲基组成的群；L选自亚甲基或亚甲烷基组成的群，只有在J为亚甲基时L才为亚甲烷基；J选自亚甲基、乙烯基、R-羟甲亚甲基、S-羟甲亚甲基或亚甲基组成的群，只有在L为亚甲烷基时J才为亚甲基；W选自--CH.sub.2 --CH--或trans --CH.dbd.C--组成的群；T.sub.1和T.sub.2连接到相邻的碳原子上；T.sub.1选自氢或苯基，只有当T.sub.2为较低的烷基时T.sub.1才为苯基；T.sub.2选自正戊基或较低的烷基，只有当T.sub.1为苯基时T.sub.2才为较低的烷基；或者T.sub.1和T.sub.2连接在一起形成含有4个或6个碳原子的烷基基团。还公开了制备这种前列腺素类似物的方法。
• Novel cyclopentane derivatives
  申请人：Hoechst Aktiengesellschaft

  公开号：US03984459A1

  公开（公告）日：1976-10-05

  The present invention relates to novel not naturally occurring 10,11-dihydro-derivatives of prostaglandins of the A-series as well as a process for their preparation. The compounds of the invention have an antiprostaglandin effect and may be used as medicaments for the inhibition or suppression pharmacological properties of the prostaglandins.

  本发明涉及A系列前列腺素的新型非天然存在的10,11-二氢衍生物，以及它们的制备方法。本发明的化合物具有抗前列腺素作用，可用作药物，用于抑制或抑制前列腺素的药理特性。
• [(4-phenyl-1,3-dioxan-cis-5-yl)alkyl]phenylalkanoic acid derivatives
  申请人：Imperial Chemical Industries PLC

  公开号：US04668698A1

  公开（公告）日：1987-05-26

  The invention concerns novel [(4-phenyl-1,3-dioxan-cis-5-yl)alkyl]phenylalkanoic acids of the formula I wherein Ra and Rb are a variety of substituents including alkyl, alkenyl, halogenoalkyl, phenyl and benzyl, or together form polymethylene; Rc is hydroxy, alkoxy or alkanesulphonamido; A.sup.1 and A.sup.2 are polymethylene; X is oxygen, sulphur or a direct bond; and benzene ring A bears a variety of substituents; and, when Rc is hydroxy, the physiologically acceptable salts thereof. The compounds of formula I are thromboxane antagonists of value in treating a variety of disease conditions. The invention also provides processes for the manufacture of, and pharmaceutical compositions of, the compounds of formula I.

  本发明涉及一种新型[(4-苯基-1,3-二氧杂环戊基)烷基]苯基脂肪酸I的化合物，其中Ra和Rb是各种取代基，包括烷基，烯基，卤代烷基，苯基和苄基，或共同形成聚亚甲基；Rc是羟基，烷氧基或烷基磺酰胺基；A.sup.1和A.sup.2是聚亚甲基；X是氧，硫或直接键；苯环A带有各种取代基；当Rc为羟基时，其生理学上可接受的盐。公式I化合物是治疗各种疾病的血栓素拮抗剂。本发明还提供了制备公式I化合物的方法和制药组合物。
• 5,6-Benzo analogues of prostaglandin
  申请人：Miles Laboratories, Inc.

  公开号：US04238623A1

  公开（公告）日：1980-12-09

  Disclosed are prostaglandin analogues having the structural formula, ##STR1## in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano; M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene; L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine; J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine; W is selected from the group consisting of ##STR2## T.sub.1 and T.sub.2 are attached to adjacent carbon atoms; T.sub.1 is selected from the group consisting of hydrogen or phenyl, provided T.sub.1 is phenyl only if T.sub.2 is lower alkyl; T.sub.2 is selected from the group consisting of n-pentyl or lower alkyl, provided T.sub.2 is lower alkyl only if T.sub.1 is phenyl; or T.sub.1 and T.sub.2 are joined together to form an alkylene group of 4 or 6 carbon atoms. Also disclosed are methods for preparing such prostaglandin analogues.

  本发明涉及具有结构式##STR1##的前列腺素类似物，其中：T选自羧基，烷氧羰基或氰基的群；M选自羰基，R-羟甲基或S-羟甲基的群；L选自亚甲基或亚胺基的群，仅当J为亚胺基时，L才为亚胺基；J选自亚甲基，乙烯基，R-羟甲基，S-羟甲基或亚胺基的群，仅当L为亚胺基时，J才为亚胺基；W选自##STR2##的群；T.sub.1和T.sub.2连接到相邻的碳原子上；T.sub.1选自氢或苯基的群，仅当T.sub.2为较低烷基时，T.sub.1才为苯基；T.sub.2选自正戊基或较低烷基的群，仅当T.sub.1为苯基时，T.sub.2才为较低烷基；或T.sub.1和T.sub.2连接在一起形成4或6个碳原子的烷基。还公开了制备这种前列腺素类似物的方法。
• Cyclohexanone-5,6-benzo analogues of prostaglandin
  申请人：Miles Laboratories, Inc.

  公开号：US04100352A1

  公开（公告）日：1978-07-11

  Disclosed are prostaglandin analogues having the structural formula, ##STR1## in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano; M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene; L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine; J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine; W is selected from the group consisting of ##STR2## T.sub.1 and T.sub.2 are attached to adjacent carbon atoms; T.sub.1 is selected from the group consisting of hydrogen or phenyl, provided T.sub.1 is phenyl only if T.sub.2 is lower alkyl; T.sub.2 is selected from the group consisting of n-pentyl or lower alkyl, provided T.sub.2 is lower alkyl only if T.sub.1 is phenyl; Or T.sub.1 and T.sub.2 are joined together to form an alkylene group of 4 or 6 carbon atoms. Also disclosed are methods for preparing such prostaglandin analogues.

  本发明涉及结构式为##STR1##的前列腺素类似物，其中：T选自羧基，烷氧羰基或氰基的群组中；M选自羰基，R-羟甲基或S-羟甲基的群组中；L选自亚甲基或亚胺基的群组中，仅当J为亚胺基时，L才为亚胺基；J选自亚甲基，乙烯基，R-羟甲基，S-羟甲基或亚胺基的群组中，仅当L为亚胺基时，J才为亚胺基；W选自##STR2##的群组中；T.sub.1和T.sub.2附着在相邻的碳原子上；T.sub.1选自氢或苯基的群组中，仅当T.sub.2为较低的烷基时，T.sub.1才为苯基；T.sub.2选自正戊基或较低的烷基的群组中，仅当T.sub.1为苯基时，T.sub.2才为较低的烷基；或T.sub.1和T.sub.2结合形成4或6个碳原子的烷基。本发明还涉及制备这种前列腺素类似物的方法。