1-Cbz-氨基-2-甲基氨基-乙烷盐酸盐 | 277328-34-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-Cbz-氨基-2-甲基氨基-乙烷盐酸盐
• 中文别名: 1-CBZ-氨基-2-甲基氨基乙烷盐酸盐
• 英文名称: benzyl 2-(methylamino)ethylcarbamate hydrochloride
• 英文别名: 1-Cbz-Amino-2-methylaminoethane hydrochloride；benzyl N-[2-(methylamino)ethyl]carbamate;hydrochloride
• CAS: 277328-34-4
• 化学式: C₁₁H₁₆N₂O₂*ClH
• 分子量: 244.721
• InChiKey: OCADBAIAKGMWBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.55
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  50.4
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2921290000
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  1-Cbz-氨基-2-甲基氨基-乙烷盐酸盐 、 [(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a-hydroxy-7-oxo-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl] (4-nitrophenyl) carbonate;hydrochloride 在 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以74%的产率得到[(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a-hydroxy-7-oxo-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl] N-methyl-N-[2-(phenylmethoxycarbonylamino)ethyl]carbamate
  参考文献：
  名称：

  WO2007/140272

  摘要：

  公开号：

文献信息

• Vitronectin receptor antagonist pharmaceuticals
  申请人：——

  公开号：US20040014964A1

  公开（公告）日：2004-01-22

  The present invention describes novel compounds of the formula: (Q) d —L n —C h , useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The present invention further provides novel compounds useful for imaging atherosclerosis, restenosis, cardiac ischemia and myocardial reperfusion injury. The present invention still further provides novel compounds useful for the treatment of rheumatoid arthritis. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.

  本发明描述了新颖化合物的公式：(Q) d-Ln-Ch，用于癌症的诊断和治疗，患者肿瘤成像方法，以及患者癌症治疗的方法。本发明还提供了新颖化合物，用于监测治疗性血管生成和新血管生成的破坏。本发明进一步提供了新颖化合物，用于成像动脉粥样硬化、再狭窄、心肌缺血和心肌再灌注损伤。本发明还提供了新颖化合物，用于类风湿性关节炎的治疗。这些药物由结合到在血管生成期间上调的受体的靶向基团、可选的连接基团和治疗有效的放射性同位素或诊断有效的可成像基团组成。可成像基团是伽马射线或正电子发射放射性同位素、磁共振成像对比剂、X射线对比剂或超声对比剂。
• Controlled release of phenolic opioids
  申请人：Pharmacofore, Inc.

  公开号：EP2402037A1

  公开（公告）日：2012-01-04

  The present invention relates to a method of providing a patient with controlled release of a phenolic opioid using a prodrug capable, upon enzymatic activation, of releasing the phenolic opioid through intra-molecular cyclization leading to formation of a cyclic urea, carbamate or thiocarbamate.

  本发明涉及一种为患者提供酚类阿片类药物控释的方法，使用的原药在酶活化后能够通过分子内环化释放酚类阿片类药物，从而形成环状脲、氨基甲酸酯或硫代氨基甲酸酯。
• CONTROLLED RELEASE OF PHENOLIC OPIOIDS
  申请人：Signature Therapeutics, Inc.

  公开号：EP2046393B1

  公开（公告）日：2014-02-12
• Prodrugs of Peripheral Phenolic Opioid Antagonists
  申请人：Jenkins Thomas E.

  公开号：US20100267614A1

  公开（公告）日：2010-10-21

  Compounds of formula (I), in which X, Y, R1, R2, n, R3 and R4 have the meanings given in the specification, are useful as pro-drugs of peripheral phenolic opioid antagonists.
• Controlled Release of Phenolic Opioids
  申请人：Jenkins Thomas E.

  公开号：US20120270894A1

  公开（公告）日：2012-10-25

  A method of providing a patient with controlled release of a phenolic opioid using a prodrug capable, upon enzymatic activation, of releasing the phenolic opioid through intra-molecular cyclization leading to formation of a cyclic urea, carbamate or thiocarbamate.