1-O-十六烷基-2-乙酰基-外消旋-甘油 | 87233-21-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 中文名称: 1-O-十六烷基-2-乙酰基-外消旋-甘油
• 英文名称: <2-Hexadecyloxy-1-(hydroxymethyl)ethyl> acetate
• 英文别名: 1-hexadecyl-2-acetylglycerol；2-acetyloxy-3-hexadecyloxy-1-propanol；3-(hexadecyloxy)-1,2-propanediol, 2-acetate；1-(Hexadecyloxy)-3-hydroxypropan-2-yl acetate；(1-hexadecoxy-3-hydroxypropan-2-yl) acetate
• CAS: 87233-21-4
• 化学式: C₂₁H₄₂O₄
• 分子量: 358.562
• InChiKey: QTEHGUUSIIWOOW-UHFFFAOYSA-N

物化性质

• 沸点：
  458.3±25.0 °C(Predicted)
• 密度：
  0.936±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  25
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2915390090

反应信息

• 作为反应物：
  描述：

  1-O-十六烷基-2-乙酰基-外消旋-甘油 在 吡啶 、 正丁基锂 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 二氯甲烷 、 氯仿 、 苯 为溶剂， 反应 97.0h， 生成
  参考文献：
  名称：

  Mlotkowska, Barbara; Olejnik, Jadwiga, Liebigs Annalen, 1995, # 8, p. 1467 - 1470

  摘要：

  DOI：
• 作为产物：
  描述：

  1-hexadecyl-2-acetyl-3-trimethylsilylglycerol 在 ammonium bifluoride 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以52%的产率得到1-O-十六烷基-2-乙酰基-外消旋-甘油
  参考文献：
  名称：

  Synthesis of some derivatives of glycerophosphocholines and their influence on the cytotoxic activity of platelets

  摘要：

  DOI：

  10.1007/bf00780200

文献信息

• Antihypertensive phosphate derivatives
  申请人：American Cyanamid Co.

  公开号：US04762942A1

  公开（公告）日：1988-08-09

  Antihypertensive phosphate derivatives having the following formula are described: ##STR1## wherein X is selected from one or more of: (a) C.sub.1 -C.sub.24 branched or straight chain alkyl; (b) C.sub.1 -C.sub.24 branched or straight chain alkoxy; (c) ##STR2## wherein n and m are integers from 0 to 25 and the sum of n and m is less than or equal to 25; phenyl; substituted phenyl wherein the substituents are selected from the group consisting of C.sub.1 -C.sub.20 branched or straight chain alkyl, C.sub.1 -C.sub.20 branched or straight chain alkoxy, halogen, trifluoromethyl, phenyl, and substituted phenyl, phenoxy; and substituted phenoxy, wherein the substituents are selected from the group consisting of C.sub.1 -C.sub.20 branched or straight chain alkyl, halogen, trifluoromethyl, phenyl and substituted phenyl; Q is selected from the group consisting of: ##STR3## wherein R.sub.1 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.4 branched or straight chain alkyl, C.sub.1 -C.sub.4 branched or straight chain alkoxy and C.sub.1 -C.sub.4 branched or straight chain alkylamino and wherein R.sub.3 is C.sub.1 -C.sub.4 alkyl, with the proviso that when Q is ##STR4## then R.sub.1 is C.sub.1 -C.sub.4 branched or straight chain alkyl; T is a bivalent radical selected from the group consisting of --(CHR).sub.p -- and ##STR5## wherein p is an integer from 1 to 15, the moiety --(CHR).sub.p -- represents an alkylene chain substituted at any position with one or more C.sub.1 -C.sub.10 alkyl groups or phenyl groups, and the moiety ##STR6## is bound with the oxygen atom attached directly to the aromatic ring; and Z is ##STR7## wherein R.sub.2 is hydrogen or C.sub.1 -C.sub.4 branched or straight chain alkyl and q is an interger from 4 to 7; in either the racemic or optically active forms.

  描述具有以下公式的抗高血压磷酸盐衍生物：##STR1##其中X从以下一个或多个中选择：(a) C.sub.1 -C.sub.24支链或直链烷基；(b) C.sub.1 -C.sub.24支链或直链烷氧基；(c) ##STR2##其中n和m是从0到25的整数，n和m的和小于或等于25；苯基；取代苯基，其中取代基选择自C.sub.1 -C.sub.20支链或直链烷基、C.sub.1 -C.sub.20支链或直链烷氧基、卤素、三氟甲基、苯基和取代苯基、苯氧基；和取代苯氧基，其中取代基选择自C.sub.1 -C.sub.20支链或直链烷基、卤素、三氟甲基、苯基和取代苯基；Q从以下一组中选择：##STR3##其中R.sub.1选择自氢、C.sub.1 -C.sub.4支链或直链烷基、C.sub.1 -C.sub.4支链或直链烷氧基和C.sub.1 -C.sub.4支链或直链烷基氨基，其中R.sub.3是C.sub.1 -C.sub.4烷基，但要注意当Q为##STR4##时，R.sub.1为C.sub.1 -C.sub.4支链或直链烷基；T是从--(CHR).sub.p --和##STR5##中选择的二价基团，其中p是从1到15的整数，基团--(CHR).sub.p --代表一个在任何位置上用一个或多个C.sub.1 -C.sub.10烷基或苯基取代的烷基链，基团##STR6##与直接连接到芳香环的氧原子结合；Z是##STR7##其中R.sub.2是氢或C.sub.1 -C.sub.4支链或直链烷基，q是从4到7的整数；可以是消旋的或光学活性形式。
• Functional associative coatings for nanoparticles
  申请人：Hainfeld James F.

  公开号：US20080089836A1

  公开（公告）日：2008-04-17

  Described herein are nanoparticles that are coated with a bilayer of molecules formed from surface binding molecules and amphiphatic molecules. The bilayer coating self assembles on the nanoparticles from readily available materials/molecules. The modular design of the bilayer coated nanoparticles provides a means for readily and efficiently optimizing the properties of the bilayer coated nanoparticle compositions. Also described herein are uses of such nanoparticles in medicine, laboratory techniques, industrial and commerical applications.

  本文描述了一种纳米颗粒，其表面涂覆有由表面结合分子和两亲分子形成的双层分子层。该双层涂层可以自组装在纳米颗粒上，使用易得的材料/分子。双层涂层纳米颗粒的模块化设计提供了一种方便和高效地优化其性质的方法。此外，本文还描述了这种纳米颗粒在医学、实验室技术、工业和商业应用中的用途。
• Hair-growing agent
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1232740A2

  公开（公告）日：2002-08-21

  The present invention provides a hair-growing agent comprising, as an active ingredient, a phosphatidic acid represented by formula (I) : (wherein R1 represents alkyl, alkenyl, alkanoyl or alkenoyl; and when R1 represents alkyl or alkenyl, R2 represents alkyl, alkenyl, alkanoyl or alkenoyl, and when R1 represents alkanoyl or alkenoyl, R2 represents alkyl or alkenyl).

  本发明提供了一种生发剂，其活性成分包括由式(I)代表的磷脂酸： (其中 R1 代表烷基、烯基、烷酰基或烯酰基；当 R1 代表烷基或烯基时，R2 代表烷基、烯基、烷酰基或烯酰基；当 R1 代表烷酰基或烯酰基时，R2 代表烷基或烯基）。
• Assays for screening activity of modulators of members of the hydroxy steroid (17-beta) dehydrogenase (HSD17B) family
  申请人：Regeneron Pharmaceuticals, Inc.

  公开号：US11479802B2

  公开（公告）日：2022-10-25

  Screening methods as well as kits for identifying modulators of hydroxysteroid (17-beta) dehydrogenase (HSD17B) family member proteins, such as HSD17B13, are provided. The methods comprise screening molecules for their capacity to modulate the HSD17B family member protein, including inhibiting the HSD17B family member protein, as measured by substrate depletion, product concentration from the HSD17B family member protein substrate conversion or NADH concentration, levels of labeled substrate, luciferin light emission, or combinations thereof. Inhibitors of HSD17B family member proteins identified through the screening methods may be used to treat liver diseases, disorders, or conditions in which the HSD17B family member protein plays a role.

  本发明提供了用于鉴定羟基类固醇（17-beta）脱氢酶（HSD17B）家族成员蛋白（如 HSD17B13）调节剂的筛选方法和试剂盒。这些方法包括筛选分子，以确定其调节 HSD17B 家族成员蛋白的能力，包括抑制 HSD17B 家族成员蛋白的能力，通过底物耗竭、HSD17B 家族成员蛋白底物转化产物浓度或 NADH 浓度、标记底物水平、荧光素发光或其组合来测量。通过筛选方法鉴定的 HSD17B 家族成员蛋白的抑制剂可用于治疗 HSD17B 家族成员蛋白起作用的肝脏疾病、失调或病症。
• Markowska, A.; Mlotkowska, B.; Olejnik, J., Phosphorus, Sulfur and Silicon and the Related Elements, 1993, vol. 77, # 1-4, p. 142
  作者：Markowska, A.、Mlotkowska, B.、Olejnik, J.、Sazala, M.

  DOI：——

  日期：——