1-[(2-甲基苯基)-苯基甲基]哌啶 | 108839-52-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-[(2-甲基苯基)-苯基甲基]哌啶
• 英文名称: 1-(phenyl(2-tolyl)methyl)piperidine
• 英文别名: 1-(phenyl(o-tolyl)methyl)piperidine；1-(2-methyl-benzhydryl)-piperidine；1-(2-Methyl-benzhydryl)-piperidin；Piperidine, 1-[(2-methylphenyl)phenylmethyl]-；1-[(2-methylphenyl)-phenylmethyl]piperidine
• CAS: 108839-52-7
• 化学式: C₁₉H₂₃N
• 分子量: 265.398
• InChiKey: DUPTUSSGYZBDQQ-UHFFFAOYSA-N

物化性质

• 沸点：
  113 °C(Press: 0.2 Torr)
• 密度：
  1.036±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-[(2-甲基苯基)-苯基甲基]哌啶 在 过氧化氢苯甲酰 、 甲苯 作用下， 生成 1-(2-methyl-benzhydryl)-piperidine-1-oxide
  参考文献：
  名称：

  Wragg et al., Journal of the Chemical Society, 1958, p. 4057,4061

  摘要：

  DOI：
• 作为产物：
  描述：

  哌啶 、 2-methyl-benzhydryl bromide 在 苯 作用下， 生成 1-[(2-甲基苯基)-苯基甲基]哌啶
  参考文献：
  名称：

  Wragg et al., Journal of the Chemical Society, 1958, p. 4057,4061

  摘要：

  DOI：

文献信息

• One-step three-component coupling of aromatic organozinc reagents, secondary amines, and aromatic aldehydes into functionalized diarylmethylamines
  作者：Erwan Le Gall、Michel Troupel、Jean-Yves Nédélec

  DOI：10.1016/j.tet.2006.08.008

  日期：2006.10

  Numerous functionalized diarylmethylamines have been synthesized in high yield according to a one-step three-component coupling between an aromatic organozinc reagent, a secondary amine, and an aromatic aldehyde. Both organozinc species and aldehyde can bear a functional group and either aromatic or non-aromatic amines can be used in this versatile procedure.

  根据芳族有机锌试剂，仲胺和芳族醛之间的一步三组分偶联，已经高产率地合成了许多官能化的二芳基甲胺。有机锌物质和醛都可以带有官能团，芳香族或非芳香族胺均可用于这种通用方法。
• Copper(I)-catalyzed coupling reaction of aryl boronic acids with N,O-acetals and N,N-aminals under atmosphere leading to α-aryl glycine derivatives and diarylmethylamine derivatives
  作者：Norio Sakai、Hiroaki Hori、Yoshihiro Yoshida、Takeo Konakahara、Yohei Ogiwara

  DOI：10.1016/j.tet.2015.05.068

  日期：2015.7

  We demonstrated a copper(I)-catalyzed coupling reaction of aryl boronic acids with N,O-acetals and N,N-aminals leading to the synthesis of alpha-aryl glycines and diarylmethylamines. Under an ambient atmosphere, this catalytic system could be applied to the activation of a C(sp(3))-O bond of N,O-acetals with an ester and an aryl group, or without a coordinating substituent, as well as to a C(sp(3))-N bond of N,N-aminals. (C) 2015 Elsevier Ltd. All rights reserved.
• Use of functionalized aromatic organozinc reagents in the three-component Mannich-type synthesis of diarylmethylamines
  作者：Erwan Le Gall、Michel Troupel、Jean-Yves Nédélec

  DOI：10.1016/j.tetlet.2006.02.056

  日期：2006.4

  Efficient syntheses of functionalized diarylmethylamines have been realized according to a one-step three-component coupling between an aromatic aldehyde, a secondary amine and an aromatic organozinc reagent. Phenyl rings can be substituted by functional groups and either aromatic or non-aromatic amines can be used in this process. (c) 2006 Elsevier Ltd. All rights reserved.