1-[(3-硝基苄氧基)甲基]吡啶氯 | 3009-13-0

• 物质功能分类: 医药中间体 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-[(3-硝基苄氧基)甲基]吡啶氯
• 中文别名: N-(3-硝基苯氧甲基)吡啶氯化物
• 英文名称: 1-(((3-Nitrobenzyl)oxy)methyl)pyridin-1-ium chloride
• 英文别名: 1-[(3-nitrophenyl)methoxymethyl]pyridin-1-ium;chloride
• CAS: 3009-13-0
• 化学式: C13H13ClN2O3
• 分子量: 280.7
• InChiKey: BITDLWAQPKSXTF-UHFFFAOYSA-M

物化性质

• 密度：
  1.3396 (rough estimate)
• 稳定性/保质期：

  遵照规定使用和储存则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  -0.94
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  58.9
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S24/25
• 危险类别码：
  R22
• 海关编码：
  2933399090

文献信息

• Derivatives of hydroxyl-bearing substrates, process for their preparation and a method of application
  申请人：Seed, Brian Sarsfield

  公开号：EP0027377A1

  公开（公告）日：1981-04-22

  A process for preparing a derivative of an hydroxyl bearing substrate by reacting an hydroxyl bearing substrate with oxirane bearing molecules to produce an oxirane ring bearing substrate; and reacting the oxirane ring with a substituted primary aromatic amine selected from primary aromatic amine alcohols and primary aromatic amine thiols. Among the compositions so produced is a stable modified hydroxyl bearing substrate or hydroxyl bearing sheet having covalently bonded thereto primary aromatic amines which can be diazotized. The diazotized substrate selectively, covalently binds proteins, polypeptides, peptides, nucleic acids, RNA, single stranded DNA, and nucleic acid hybrids.

  一种制备含羟基基材衍生物的工艺，其方法是将含羟基基材与含环氧乙烷分子反应，生成含环氧乙烷基材；再将环氧乙烷与选自伯胺醇和伯胺硫醇的取代伯胺反应。在这样制得的组合物中，有一种稳定的改性含羟基基材或含羟基薄片，其上共价键有可重氮化的伯胺。重氮化基质可选择性地共价结合蛋白质、多肽、肽、核酸、RNA、单链 DNA 和核酸杂交体。
• DNA sequences, recombinant DNA molecules and processes for producing human fibroblast interferon
  申请人：BIOGEN, INC.

  公开号：EP0041313A2

  公开（公告）日：1981-12-09

  A DNA sequence consisting of the DNA inserts of G-pBR322(Pst)/HFIF1, G-pBR322(Pst)/HFIF3, G-pBR322 (Pst)/HFIF-6, G-pBR322(Pst)/HFIF7, DNA sequences which hybridize to any of the foregoing DNA inserts and DNA sequences, from whatever source obtained, including natural, synthetic or semi-synthetic sources, related by mutation, including single or multiple, base substitutions, deletions, insertions and inversions to any of the foregoing DNA sequences or inserts.

  由 G-pBR322(Pst)/HFIF1、G-pBR322(Pst)/HFIF3、G-pBR322(Pst)/HFIF-6、G-pBR322(Pst)/HFIF7 的 DNA 插入物、与前述任何 DNA 插入物杂交的 DNA 序列和 DNA 序列组成的 DNA 序列、无论其来源如何，包括天然、合成或半合成来源，与前述任何 DNA 序列或插入物相关的突变，包括单个或多个碱基置换、缺失、插入和反转。
• Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
  申请人：MILES INC.

  公开号：EP0163220A2

  公开（公告）日：1985-12-04

  A nucleic acid hybridization assay employing an immobilized or immobilizable polynucleotide probe selected to form DNA'RNA or RNA'RNA hybrids with the particular polynucleotide sequence to be determined. Resulting hybrids are detected by binding of an antibody reagent, preferably labeled with a detectable chemical group, selective for binding the hybrids in the presence of the single stranded sample and probe nucleic acids. No immobilization or labeling of sample nucleic acids is necessary and hybridization can be performed entirely in solution.

  一种核酸杂交检测方法，采用固定或可固定的多核苷酸探针，与待测定的特定多核苷酸序列形成 DNA'RNA 或 RNA'RNA 杂交体。 通过抗体试剂（最好用可检测的化学基团标记）的结合检测杂交体，抗体试剂在单链样本核酸和探针核酸存在的情况下可选择性地结合杂交体。 无需固定或标记样本核酸，杂交可完全在溶液中进行。
• Nucleic acid hybridization assay
  申请人：MILES INC.

  公开号：EP0339686A1

  公开（公告）日：1989-11-02

  A nucleic acid hybridization assay employing an immobilized or immobilizable polynucleotide probe selected to form DNA˙RNA or RNA˙RNA hybrids with the particular polynucleotide sequence to be determined. Resulting hybrids are detected by binding of an antibody reagent, preferably labeled with a detectable chemical group, selective for binding the hybrids in the presence of the single stranded sample and probe nucleic acids. No immobilization or labeling of sample nucleic acids is necessary and hybridization can be performed entirely in solution.

  核酸杂交试验，采用固定或可固定的多核苷酸探针，与待测定的特定多核苷酸序列形成 DNA˙RNA 或 RNA˙RNA 杂交体。在单链样品和探针核酸存在的情况下，抗体试剂（最好标记有可检测的化学基团）可选择性地结合杂交体，从而检测所产生的杂交体。无需固定或标记样本核酸，杂交可完全在溶液中进行。
• A method of determining the presence of endotoxin in a sample
  申请人：Baek, Leif

  公开号：EP0291856B1

  公开（公告）日：1994-12-28