毒壤膦 | 327-98-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 毒壤膦
• 中文别名: 壤虫磷；毒壤磷;毒壤膦；O-乙基-O-2，4，5-三氯苯基乙基硫代磷酸酯；毒壤磷
• 英文名称: trichloronate
• 英文别名: Trichloronat；ethoxy-ethyl-sulfanylidene-(2,4,5-trichlorophenoxy)-λ5-phosphane
• CAS: 327-98-0
• 化学式: C₁₀H₁₂Cl₃O₂PS
• 分子量: 333.603
• InChiKey: ANIAQSUBRGXWLS-UHFFFAOYSA-N

物化性质

• 稳定性/保质期：

  明火可燃，受热会释放出有毒的氧化磷、氯化物和氧化硫气体。

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  3

ADMET

代谢

Presumably, as with thiophosphates, oxidation to the phosphate and hydrolytic cleavage of the ester-bound ethyl group and the trichlorophenol group. 大概就像硫代磷酸盐一样，通过氧化形成磷酸，并且通过水解断裂酯键连接的乙基团和三氯苯酚基团。

Presumably, as with thiophosphates, oxidation to the phosphate and hydrolytic cleavage of the ester-bound ethyl group and the trichlorophenol group.

来源:Hazardous Substances Data Bank (HSDB)

代谢

血浆和组织酶负责将有机磷化合物水解成相应的磷酸和磷onic酸。然而，氧化酶也参与一些有机磷化合物的代谢。抗胆碱酯酶剂

Plasma and tissue enzymes are responsible for hydrolysis /of organophosphorus compounds/ to the corresponding phosphoric and phosphonic acids. However, oxidative enzymes are also involved in the metabolism of some organophosphorus compounds. /Anticholinesterase agents/

来源:Hazardous Substances Data Bank (HSDB)

代谢

有机磷抗胆碱酯酶剂在体内被一组称为A-酯酶或对氧磷酶的酶以及细胞色素P-450系统水解。人类群体对通过这些途径的有机磷代谢存在相当大的变异性。A-酯酶存在于血浆和肝脏内质网中，能够水解大量有机磷化合物...通过分裂无水物、P-F、P-CN或酯键。/抗胆碱酯酶剂/

The organophosphorus anticholinesterase agents are hydrolyzed in the body by a group of enzymes known as A-esterases or paroxonase, and by the cytochrome p-450 systems. Considerable variability exists in the human population for organophosphate metabolism by these routes. The A-esterases are found in plasma and in the hepatic endoplasmic reticulum and can hydrolyze a large number of organophosphorus compounds ... by splitting the anhydride, P-F, P-CN, or ester bond. /Anticholinesterase agents/

来源:Hazardous Substances Data Bank (HSDB)

代谢

这些化合物通过肝脏中的细胞色素P450介导的单加氧酶进行解毒，但一些代谢产物比母体化合物更有毒性...通常在接触后12到48小时可以检测到代谢产物。/有机磷化合物/

These chemicals are detoxified by cytochrome p450-mediated monooxygenases in the liver, but some metabolites are more toxic than parent cmpd ... Metabolites usually are detected from 12 to 48 hr postexposure. /Organophosphate cmpd/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

神经毒素 - 主要影响运动神经

Neurotoxin - Predominantly motor

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 毒性数据

LCLo（大鼠）= 700 毫克/立方米/4小时

LCLo (rat) = 700 mg/m3/4hr

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 相互作用

一些吩噻嗪类药物可能拮抗，而另一些可能增强有机磷杀虫剂的毒性抗胆碱酯酶效果。/有机磷胆碱酯酶抑制剂/

Some phenothiazines may antagonize & some may potentiate the toxic anticholinesterase effects of ... /organophosphorus insecticides/. /Organophosphate cholinesterase inhibitors/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

在长期治疗中，肾上腺皮质激素对抗抗胆碱酯酶的抗青光眼作用（增加眼内压）。... 抗胆碱药对抗抗胆碱酯酶在自主神经和中央神经系统上的缩瞳（抗青光眼）和其他毒蕈碱作用。三环类抗抑郁药（抗胆碱能作用）对抗抗胆碱酯酶在青光眼中的抗青光眼（缩瞳）作用。... 具有抗胆碱能作用的抗组胺药对抗抗胆碱酯酶的缩瞳（抗青光眼）和中央神经系统作用。抗胆碱酯酶增强由抗组胺药引起的镇静和行为改变。抗胆碱酯酶药物在自主效应细胞上的作用，以及在某种程度上对中枢神经系统的作用，可被阿托品这种首选解毒剂所拮抗。巴比妥类药物的作用可被抗胆碱酯酶增强。... 二泛醇增强抗胆碱酯酶的效果。氟磷酸盐杀虫剂增强其他抗胆碱酯酶的效果。/抗胆碱酯酶/

In long term therapy, adrenocorticoids antagonize the antiglaucoma effects of anticholinesterases (incr ocular pressure). ... Anticholinergics antagonize the miotic (antiglaucoma) & other muscarinic effects of anticholinesterases on the autonomic & central nervous systems. Tricyclic antidepressants (anticholinergic effects) antagonize the antiglaucoma (miotic) effects of anticholinesterases in glaucoma. ... Antihistamines with anticholinergic effects antagonize the miotic (antiglaucoma) & CNS effects of anticholinesterases. Anticholinesterases potentiate tranquilizing & behavioral changes induced by antihistamines. The actions of anticholinesterase agents on autonomic effector cells, & to some extent those on CNS, are antagonized by atropine, an antidote of choice. Barbiturates are potentiated by anticholinesterases. ... Dexpanthenol potentiates the effects of anticholinesterases. Fluorophosphate insecticides potentiate the effects of other anticholinesterases. /Anticholinesterases/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

巴比妥类药物可被抗胆碱酯酶增强。尽管巴比妥类药物可以谨慎用于治疗癫痫，但在处理由于抗胆碱酯酶导致的毒物中毒时，必须极度小心，特别是对于有机磷杀虫剂。毒扁豆碱，一种用作缩瞳剂胆碱酯酶抑制剂，可增强其他类似抑制剂的效果...用于其他目的（相加效应）或可能的协同作用。那些接触有机磷杀虫剂的人必须采取严格预防措施。...有机磷杀虫剂：附加的抗胆碱酯酶效果。危险。使用抗胆碱酯酶的患者（即使是局部的，如眼药水）应避免去最近使用过有机磷杀虫剂的地方。/抗胆碱酯酶/

BARBITURATES ARE POTENTIATED BY ANTICHOLINESTERASES. ALTHOUGH BARBITURATES MAY BE USED CAUTIOUSLY IN TREATING CONVULSIONS, EXTREME CARE IS ESSENTIAL IN HANDLING POISONINGS DUE TO ANTICHOLINESTERASES, PARTICULARLY ORGANOPHOSPHORUS PESTICIDES. ECHOTHIOPHATE, A CHOLINESTERASE INHIBITOR USED AS MIOTIC, POTENTIATES OTHER SUCH INHIBITORS ... USED FOR OTHER PURPOSES (ADDITIVE EFFECTS) OR POSSIBLY SYNERGISTIC. THOSE EXPOSED TO ORGANOPHOSPHATE INSECTICIDES MUST TAKE STRICT PRECAUTIONS. ... ORGANOPHOSPHORUS INSECTICIDES: ADDITIVE ANTICHOLINESTERASE EFFECTS. HAZARDOUS. PATIENTS ON ANTICHOLINESTERASES (EVEN TOPICAL, SUCH AS EYE DROPS) SHOULD AVOID AREAS WHERE ORGANOPHOSPHORUS INSECTICIDES ... RECENTLY ... USED. /ANTICHOLINESTERASE/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

大多数有机磷化合物能够通过皮肤、结膜、胃肠道和肺部被吸收。/有机磷化合物/

Most organophosphate compounds are ... absorbed from skin, conjunctiva, gastrointestinal tract, & lung. /Organophosphate compounds/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

有机磷农药的皮肤吸收率可能会受到所使用溶剂的影响。

The rate of dermal absorption /of organophosphorus pesticides/ may be ... influenced by the solvent used. /Organophosphorus pesticides/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

许多有机磷杀虫剂会通过牛奶排出体外... /有机磷杀虫剂/

Many of the organophosphorus insecticides are excreted in the milk ... /Organophosphorus insecticides/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

有机磷化合物被吸收后，大部分以水解产物的形式几乎完全通过尿液排出。/抗胆碱酯酶剂/

Following their absorption, most organophosphorus cmpd are excreted almost entirely as hydrolysis products in the urine. /Anticholinesterase agents/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 储存条件：
  库房应保持通风、低温和干燥，并与食品原料分开储运。

反应信息

• 作为反应物：
  描述：

  Indolocarbazole nitrogen derivative 、 毒壤膦 生成 staurosporine
  参考文献：
  名称：

  COMPOSITIONS COMPRISING BETA-CARYOPHYLLENE AND METHODS OF UTILIZING THE SAME

  摘要：

  本发明提供了诱导癌细胞或被Epstein-Barr病毒（EBV）转化的细胞凋亡的组合物和方法。具体而言，本发明提供β-石竹烯或其组合物来诱导凋亡。本发明还提供通过给予β-石竹烯或其组合物来治疗淋巴瘤或与Epstein-Barr病毒（EBV）相关的疾病的方法。

  公开号：

  US20140030289A1
• 作为产物：
  描述：

  Sodium;2,4,5-trichlorophenolate;hydrate 、 alkaline earth salt of/the/ methylsulfuric acid 在 丁酮 作用下， 生成 毒壤膦
  参考文献：
  名称：

  DE1099530

  摘要：

  公开号：

文献信息

• [EN] MICROBIOCIDAL OXADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'OXADIAZOLE MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017157962A1

  公开（公告）日：2017-09-21

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.

  式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是杀菌剂有用。
• Thieno-pyrimidine compounds having fungicidal activity
  申请人：Brewster Kirkland William

  公开号：US20070093498A1

  公开（公告）日：2007-04-26

  The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.

  本发明涉及具有杀真菌活性的噻吩[2,3-d]-嘧啶化合物。
• [EN] INSECTICIDAL TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2013079350A1

  公开（公告）日：2013-06-06

  Compounds of the formula (I) or (I'), wherein the substituents are as defined in claim 1, are useful as pesticides.

  式(I)或(I')的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。
• Novel insecticides
  申请人：Syngenta Participations AG

  公开号：EP2540718A1

  公开（公告）日：2013-01-02

  Compounds of formula I wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as insecticides and can be prepared in a manner known per se.

  式I的化合物 其中取代基如权利要求1所定义，并且式I化合物的农药可接受盐以及所有立体异构体和互变异构形式可用作杀虫剂，并且可以按照已知的方法制备。
• Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
  申请人：Dow AgroSciences LLC

  公开号：US20180279612A1

  公开（公告）日：2018-10-04

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫具有杀虫效用的分子领域，用于生产此类分子的过程，用于此类过程的中间体，含有此类分子的杀虫组合物，以及使用此类杀虫组合物对抗此类害虫的过程。这些杀虫组合物可以用作螨虫剂、杀虫剂、螨虫剂、软体动物杀虫剂和线虫杀虫剂。本文件披露了具有以下式（“式一”）的分子。