1-[丁氧基(苯基)甲基]哌啶 | 5351-11-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-[丁氧基(苯基)甲基]哌啶
• 英文名称: 1-(butoxyphenylmethyl)piperidine
• 英文别名: 1-(butoxy-phenyl-methyl)-piperidine；1-(α-butoxy-benzyl)-piperidine；1-(α-Butoxy-benzyl)-piperidin；1-(α-Butoxybenzyl)-piperidin；N-(α-Butoxybenzyl)-piperidin；N-(α-Butoxybenzyl)piperidin；1-[Butoxy(phenyl)methyl]piperidine
• CAS: 5351-11-1
• 化学式: C₁₆H₂₅NO
• 分子量: 247.381
• InChiKey: RXVXIYHFUSOSMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-[丁氧基(苯基)甲基]哌啶 在 萘 、 lithium 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 7.17h， 生成 1-苄基哌啶
  参考文献：
  名称：

  α-氨基取代的芳基甲基锂有机金属化合物的产生和反应性

  摘要：

  开链和环状α - N，N-二烷基氨基取代的苄基烷基醚1a - f的还原裂解，分散有Li金属和催化量的萘在THF中，可以轻松获得各种α- N，N -二烷基氨基取代的苄基锂衍生物。这些有机金属与各种亲电试剂的反应以令人满意的产率提供了预期的产物。

  DOI：

  10.1016/s0040-4020(00)00303-3
• 作为产物：
  描述：

  哌啶 在 potassium carbonate 、 苯 作用下， 生成 1-[丁氧基(苯基)甲基]哌啶
  参考文献：
  名称：

  Synthesis and Reactions of α-Dialkylaminobenzyl Butyl Ethers. Interactions with Grignard Reagents to Form Tertiary Amines¹

  摘要：

  DOI：

  10.1021/ja01610a006

文献信息

• The tandem insertion of lithium chloroallylide and various electrophiles into zirconacyclopentanes
  作者：Tim Luker、Richard J. Whitby

  DOI：10.1016/0040-4039(95)00650-2

  日期：1995.6

  Insertion of lithium chloroallylide into a bicyclic zirconacyclopentane yields a zirconocene allyl complex which reacts with a variety of C, N, O and S containing electrophiles to give elaborated cyclopentane products on work-up. An intramolecular version of this tandem protocol gives a stereospecific synthesis of a (E)-alkylidenecyclohexane.

  将氯代烯丙基锂插入双环氧化锆环戊烷中可生成锆茂烯丙基配合物，该配合物与各种含C，N，O和S的亲电试剂反应，在后处理时得到精细的环戊烷产物。该串联方案的分子内版本提供了（E）-亚烷基环己烷的立体有择合成。
• Smith, Peter James; Amin, Md., Canadian Journal of Chemistry, 1989, vol. 67, p. 1457 - 1467
  作者：Smith, Peter James、Amin, Md.

  DOI：——

  日期：——
• A Scrutiny on the Reductive Amination of Carbonyl Compounds Catalyzed by Homogeneous Rh(I) Diphosphane Complexes
  作者：Vitali I. Tararov、Renat Kadyrov、Thomas H. Riermeier、Armin Börner

  DOI：10.1002/1615-4169(200202)344:2<200::aid-adsc200>3.0.co;2-4

  日期：2002.2

  The reductive amination of a series of aldehydes with secondary amines and H-2 in the presence of a homogeneous Rh-diphosphane catalyst was studied in order to establish a general mechanism of this reaction and to identify conditions for the improvement of the amine/alcohol ratio in the product. Several possible intermediates as constituents of changing equilibria like half-aminals. N,O-acetals and aminals were observed in the reaction mixture by means of H-1 NMR spectroscopy. In individual trials, these compounds could be successfully hydrogenated under the conditions applied for reductive amination (50 bar H-2 pressure, MeOH). Some evidence is accumulated that half-aminals and N,O-acetals might be key intermediates of the reductive amination. Moreover, it was found that the formation of the undesired product alcohol is likely based on the reduction of the starting carbonyl compound. However, due to numerous equilibria consisting of several intermediates, general conclusions are hard to be drawn. Proof will be given that, in several cases, the efficiency of the reductive amination of aliphatic aldehydes can be significantly improved by prehydrogenation of the cationic [Rh(dppb)(COD)](+) complex.
• A Convenient Synthesis of<i>N</i>,<i>N</i>-Disubstituted Aminomethyltri-<i>n</i>-butylstannanes, Precursors of the Corresponding Lithium Reagents
  作者：Jean-Paul Quintard、Bernard Elissondo、Bernard Jousseaume

  DOI：10.1055/s-1984-30879

  日期：——
• Canceill,J. et al., Bulletin de la Societe Chimique de France, 1966, p. 3612 - 3617
  作者：Canceill,J. et al.

  DOI：——

  日期：——