1-丁酰基吡咯烷-2-酮 | 22707-38-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1-丁酰基吡咯烷-2-酮
• 英文名称: N-Butyryl-pyrrolidon-(2)
• 英文别名: N-Butyryl-γ-butyrolactam；1-butyryl-pyrrolidin-2-one；1-Butyryl-pyrrolidin-2-on；1-Butanoylpyrrolidin-2-one
• CAS: 22707-38-6
• 化学式: C₈H₁₃NO₂
• 分子量: 155.197
• InChiKey: JTDHUAGBXUTEAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-丁酰基吡咯烷-2-酮 生成 2-吡咯烷酮
  参考文献：
  名称：

  MACHIDA MINORU; TAKECHI HARUKO; SAKUSHIMA AKIYO; KANAOKA YUICHI, HETEROCYCLES, 1981, 15, NO 1, SPEC. ISSUE, 479-480

  摘要：

  DOI：
• 作为产物：
  描述：

  2-吡咯烷酮 、 丁酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 1-丁酰基吡咯烷-2-酮
  参考文献：
  名称：

  Synthesis and anticonvulsant activity of 1-acyl-2-pyrrolidinone derivatives

  摘要：

  Several 1-acyl-2-pyrrolidinone derivatives were synthesized as derivatives of gamma-aminobutyric acid (GABA), and their pharmacological activities and stabilities were investigated. The derivatives showed anticonvulsant effect on picrotoxin-induced seizure at a dose of 200 mg/kg. In particular, 1-decanoyl-2-pyrrolidinone (7) and 1-dodecanoyl-2-pyrrolidinone (8) had a high activity. The anticonvulsant activity showed a dose dependency. Some of 1-acyl-2-pyrrolidinone derivatives prolonged sleeping time which was induced by sodium pentobarbital and showed a recovery from disruption of the memory of passive avoidance response, which was induced by an electroconvulsive shock. As shown by the results of the stability study of 1-acetyl-2-pyrrolidinone (1), it was degraded in an acidic buffer and an alkaline buffer although 2-pyrrolidinone was stable. 1-Acyl-2-pyrrolidinone derivatives were degraded in liver and brain homogenates of mouse and rat. They showed a degradation rate in rat plasma. Conversion of 8 to GABA in mouse liver homogenate was demonstrated. These results suggested that the pharmacological activity of 1-acyl-2-pyrrolidinone is probably due to the release of GABA by hydrolysis of derivatives although further work is necessary.

  DOI：

  10.1021/jm00106a025

文献信息

• TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Babu Srinivasan

  公开号：US20110201593A1

  公开（公告）日：2011-08-18

  The invention provides novel compounds of formula I having the general formula: wherein R 1 , R 2 , R 3 , X and Y are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.

  本发明提供了具有以下一般式的新化合物I： 其中R1、R2、R3、X和Y如本文所述。因此，这些化合物可以在药学上可接受的组合物中提供，并用于治疗免疫或过度增生性疾病。
• Reppe et al., Justus Liebigs Annalen der Chemie, 1955, vol. 596, p. 1,176,201
  作者：Reppe et al.

  DOI：——

  日期：——
• SASAKI, HITOSHI;MORI, YOSHIYKI;NAKAMURA, JUNZO;SHIBASAKI, JUICHIRO, J. MED. CHEM., 34,(1991) N, C. 628-633
  作者：SASAKI, HITOSHI、MORI, YOSHIYKI、NAKAMURA, JUNZO、SHIBASAKI, JUICHIRO

  DOI：——

  日期：——
• Skinpenetration enhancing compositions
  申请人：WHITBY RESEARCH, Inc.

  公开号：EP0257086B1

  公开（公告）日：1993-01-20
• Penetration enhancers for transdermal delivery of systemic agents
  申请人：WHITBY RESEARCH, Inc.

  公开号：EP0268218B1

  公开（公告）日：1992-05-06