1-乙基-10H-吩噻嗪 | 83838-27-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 中文名称: 1-乙基-10H-吩噻嗪
• 英文名称: 1-ethylphenothiazine
• 英文别名: 1-Ethyl-phenothiazin；1-ethyl-10H-phenothiazine；1-Aethyl-phenothiazin；1-ethyl-10H-phenothiazine
• CAS: 83838-27-1
• 化学式: C₁₄H₁₃NS
• 分子量: 227.33
• InChiKey: VTRJBCXAWFGCBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-乙基-10H-吩噻嗪 、 N,N-二乙基氯乙胺 生成 N-(2-Diethylamino-ethyl)-1-ethyl-phenothiazin
  参考文献：
  名称：

  Takada,A.; Nishimura,H., Chemical and pharmaceutical bulletin, 1962, vol. 10, p. 1 - 8

  摘要：

  DOI：
• 作为产物：
  描述：

  2-乙基乙酰苯胺 在 碘 、 sulfur 作用下， 生成 1-乙基-10H-吩噻嗪
  参考文献：
  名称：

  Takada,A.; Nishimura,H., Chemical and pharmaceutical bulletin, 1962, vol. 10, p. 1 - 8

  摘要：

  DOI：

文献信息

• Specific Synthesis of 1-Substituted Phenothiazines Using Carbon Dioxide Protection of the NH Group During Lithiation
  作者：Alan R. Katritzky、Luis M. Vazquez de Miguel、Gordon W. Rewcastle

  DOI：10.1055/s-1988-27515

  日期：——

  The lithiation of phenothiazine when protected as the lithium salt of its carbamate occurs exclusively at the C-1 carbon atom. Reaction of the lithiated species with a variety of electrophiles readily produced several new 1-substituted phenothiazines, as well as a number of known compounds in superior yield to existing methods.

  吩噻嗪作为氨基甲酸酯的锂盐受到保护时，其锂化作用只发生在 C-1 碳原子上。锂化产物与多种亲电体反应后，很容易生成几种新的 1-取代吩噻嗪以及一些已知化合物，其产量优于现有方法。
• Antiviral Compounds
  申请人：Hurt Clarence

  公开号：US20120157435A1

  公开（公告）日：2012-06-21

  Compounds and methods for preventing and treating viral infections are provided. In some embodiments, novel compounds broad-spectrum antiviral activity are provided. In more specific embodiments, the compounds and methods are effective against viruses such as Venezuelan Equine Encephalitis, West Nile Virus, and respiratory viruses including the common cold.

  提供了预防和治疗病毒感染的化合物和方法。在某些实施例中，提供了具有广谱抗病毒活性的新型化合物。在更具体的实施例中，这些化合物和方法对委内瑞拉马脑炎病毒、西尼罗河病毒以及包括普通感冒在内的呼吸道病毒具有有效性。
• Antiviral compounds
  申请人：Hurt Clarence R.

  公开号：US08785434B2

  公开（公告）日：2014-07-22

  Compounds and methods for preventing and treating viral infections are provided. In some embodiments, novel compounds broad-spectrum antiviral activity are provided. In more specific embodiments, the compounds and methods are effective against viruses such as Venezuelan Equine Encephalitis, West Nile Virus, and respiratory viruses including the common cold.

  提供预防和治疗病毒感染的化合物和方法。在某些实施例中，提供了具有广谱抗病毒活性的新型化合物。在更具体的实施例中，这些化合物和方法对委内瑞拉马蚊脑炎病毒、西尼罗河病毒以及包括普通感冒在内的呼吸道病毒具有有效性。
• Compounds, compositions, and methods for treating Alzheimer's disease
  申请人：Lingappa Vishwanath

  公开号：US08796448B1

  公开（公告）日：2014-08-05

  Novel methods and compounds for treating Alzheimer's Disease are provided. In one aspect, the invention provides methods for treating Alzheimer's Disease by administering certain phenothiazine derivatives. In one embodiment, the methods include administering an effective amount of a 3-oxo-7-dialkyl-amino-phenothiazine derivative, or 3-oxo-7-dialkyl-amino-phenothiazine. In another embodiment, the invention provides methods for treating Alzheimer's Disease by administering an effective amount of a 3,7-diazetidin-1-yl-phenothiazine or a derivative thereof. In another aspect, the invention provides novel azetidinyl phenothiazine compounds.

  本发明提供了治疗阿尔茨海默病的新方法和化合物。在一个方面，本发明提供了通过给予某些苯噻嗪衍生物来治疗阿尔茨海默病的方法。在一个实施例中，该方法包括给予有效量的3-氧代-7-二烷基氨基-苯噻嗪衍生物或3-氧代-7-二烷基氨基-苯噻嗪。在另一个实施例中，本发明提供了通过给予有效量的3,7-二氮杂-1-基苯噻嗪或其衍生物来治疗阿尔茨海默病的方法。在另一个方面，本发明提供了新型的氮杂环苯噻嗪化合物。
• COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING ALZHEIMER'S DISEASE
  申请人：Prosetta Antiviral Inc.

  公开号：US20140315897A1

  公开（公告）日：2014-10-23

  Novel methods and compounds for treating Alzheimer's Disease are provided. In one aspect, the invention provides methods for treating Alzheimer's Disease by administering certain phenothiazine derivatives. In one embodiment, the methods include administering an effective amount of a 3-oxo-7-dialkyl-amino-phenothiazine derivative, or 3-oxo-7-dialkyl-amino-phenothiazine. In another embodiment, the invention provides methods for treating Alzheimer's Disease by administering an effective amount of a 3,7-diazetidin-1-yl-phenothiazine or a derivative thereof. In another aspect, the invention provides novel azetidinyl phenothiazine compounds.

  本发明提供了治疗阿尔茨海默病的新方法和化合物。在一个方面，本发明提供了通过给予某些苯并噻嗪衍生物治疗阿尔茨海默病的方法。在一个实施例中，该方法包括给予有效量的3-氧代-7-二烷基氨基苯并噻嗪衍生物或3-氧代-7-二烷基氨基苯并噻嗪。在另一个实施例中，本发明提供了通过给予有效量的3,7-二氮杂-1-基苯并噻嗪或其衍生物治疗阿尔茨海默病的方法。在另一个方面，本发明提供了新的氮杂环苯并噻嗪化合物。