1-乙基-2,5-二甲基-1H-苯并咪唑 | 2818-63-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 1-乙基-2,5-二甲基-1H-苯并咪唑
• 英文名称: 1-Aethyl-2.5-dimethyl-benzimidazol
• 英文别名: 1-ethyl-2,5-dimethyl-1H-benzoimidazole；1-Aethyl-2,5-dimethyl-1H-benzimidazol；1-Ethyl-2,5-dimethyl-1H-benzo[d]imidazole；1-ethyl-2,5-dimethylbenzimidazole
• CAS: 2818-63-5
• 化学式: C₁₁H₁₄N₂
• 分子量: 174.246
• InChiKey: LWGBOYPDVJEMQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-乙基-2,5-二甲基-1H-苯并咪唑 生成 2,5-二甲基-1H-苯并咪唑
  参考文献：
  名称：

  Fischer,O.; Rigaud, Chemische Berichte, 1901, vol. 34, p. 4204

  摘要：

  DOI：
• 作为产物：
  描述：

  acetic acid-(N-ethyl-4-methyl-2-nitro-anilide) 在 溶剂黄146 、 锌 作用下， 生成 1-乙基-2,5-二甲基-1H-苯并咪唑
  参考文献：
  名称：

  Niementowski, Chemische Berichte, 1887, vol. 20, p. 1884

  摘要：

  DOI：

文献信息

• [EN] ARYL AND HETEROARYL ETHER COMPOUNDS AS ROR GAMMA MODULATORS<br/>[FR] COMPOSÉS ÉTHER D'ARYLE ET ÉTHER D'HÉTÉROARYLE EN TANT QUE MODULATEURS DE ROR GAMMA
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2017051319A1

  公开（公告）日：2017-03-30

  Provided are compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R 1, R 2, R a, R b, n, x, y and z are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORyt).

  提供的是式（I）的化合物及其药用盐，其中环A、环B、L、R1、R2、Ra、Rb、n、x、y和z的定义如本文所述，这些化合物作为视黄醇相关孤儿受体γt（RORγt）的调节剂具有活性。
• Non-basic melanin concentrating hormone receptor-1 antagonists
  申请人：Ahmad Saleem

  公开号：US20070093508A1

  公开（公告）日：2007-04-26

  The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I.

  本申请提供了根据式I提供的化合物，包括所有立体异构体、溶剂合物、前药和药学上可接受的形式。此外，本申请提供了含有至少一种根据式I的化合物和可选至少一种额外治疗剂的药物组合物。最后，本申请提供了治疗患有MCHR-1调节性疾病或紊乱（例如肥胖症、糖尿病、抑郁症或焦虑症）的患者的方法，通过给予根据式I的化合物的治疗有效剂量。
• MATERIAL FOR ORGANIC ELECTROLUMINESCENCE ELEMENT, AND ORGANIC ELECTROLUMINESCENCE ELEMENT USING SAME
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：EP2555271A1

  公开（公告）日：2013-02-06

  Provided is a material for an organic electroluminescence device, which further has a bulky carbazolyl group at each of the 3-position and 6-position of its central carbazole skeleton, and which has a dibenzofuran skeleton or a dibenzothiophene skeleton at the N atom of the central carbazole skeleton through a linking group as required. Also provided is an organic electroluminescence device, including one or more organic thin film layers including a light emitting layer between a cathode and an anode, in which at least one layer of the organic thin film layers contains the material for an organic electroluminescence device.

  本发明提供了一种用于有机电致发光器件的材料，该材料在其中心咔唑骨架的 3 位和 6 位上各进一步具有一个笨重的咔唑基，并且根据需要在中心咔唑骨架的 N 原子上通过连接基团具有二苯并呋喃骨架或二苯并噻吩骨架。还提供了一种有机电致发光器件，包括一个或多个有机薄膜层，其中包括阴极和阳极之间的发光层，在有机薄膜层中至少有一层含有有机电致发光器件的材料。
• FLUORESCENT DYE, PREPARATION METHOD THEREFOR AND USE THEREOF
  申请人：Shenzhen University

  公开号：EP3744810A1

  公开（公告）日：2020-12-02

  Disclosed are a fluorescent dye, a preparation method and an application thereof. The fluorescent dye has a general structural formula as shown in formula (I), wherein X and Y are same or different and selected from O, S, C(CH3)2 or NR6; R2 and R3 are the same or different and selected from hydrogen or a functional group; R1, R4, R5 and R6 are all functional groups; and Z- is a negative ion. The fluorescent dye has an ability to permeate the living cell membrane, so that it can be used in the fluorescence imaging of living cell microstructures, and can also be used in the STED super-resolution fluorescence imaging and laser scanning confocal microscopy of live cells.

  本发明公开了一种荧光染料及其制备方法和应用。该荧光染料的结构通式如式（I）所示，其中X和Y相同或不同，选自O、S、C(CH3)2或NR6；R2和R3相同或不同，选自氢或官能团；R1、R4、R5和R6均为官能团；Z-为负离子。该荧光染料具有渗透活细胞膜的能力，因此可用于活细胞微结构的荧光成像，也可用于活细胞的 STED 超分辨率荧光成像和激光扫描共聚焦显微镜。
• Fluorescent dye, preparation method therefor and use thereof
  申请人：Shenzhen University

  公开号：US10889719B2

  公开（公告）日：2021-01-12

  Disclosed are a fluorescent dye, a preparation method and an application thereof. The fluorescent dye has a structure of formula (I), where X and Y are independently selected from O, S, C(CH3)2 and NR6; R2 and R3 are independently hydrogen or a functional group; R1, R4, R5 and R6 are independently selected from functional groups; and Z− is a negative ion. The fluorescent dye has an ability to permeate the living cell membrane, so that it can be used in the fluorescence imaging of living cell microstructures, and can also be used in the STED super-resolution fluorescence imaging and laser scanning confocal microscopy of live cells.

  本发明公开了一种荧光染料及其制备方法和应用。该荧光染料具有式（I）结构，其中 X 和 Y 独立地选自 O、S、C(CH3)2 和 NR6；R2 和 R3 独立地为氢或官能团；R1、R4、R5 和 R6 独立地选自官能团；Z- 为负离子。该荧光染料具有渗透活细胞膜的能力，因此可用于活细胞微结构的荧光成像，也可用于活细胞的 STED 超分辨率荧光成像和激光扫描共聚焦显微镜。