N-(4-(pyridin-3-yl)thiazol-2-yl)isoxazole-5-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(4-(pyridin-3-yl)thiazol-2-yl)isoxazole-5-carboxamide
• 英文别名: N-(4-pyridin-3-yl-1,3-thiazol-2-yl)-1,2-oxazole-5-carboxamide
• 化学式: C₁₂H₈N₄O₂S
• 分子量: 272.28
• InChiKey: KBLSZLQPXLARAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Compositions and methods for modulating inflammatory and degenerative disorder
  申请人：University of Southern California

  公开号：US11420964B2

  公开（公告）日：2022-08-23

  The disclosure provides compounds and method useful for modulating gp130 biological activity. The disclosure also provides methods and compositions for treating disease and disorders associated with gp130 activity, particularly those associated with inflammation.

  本公开提供了用于调节 gp130 生物活性的化合物和方法。本公开还提供了治疗与 gp130 活性有关的疾病和失调的方法和组合物，特别是与炎症有关的疾病和失调。
• COMPOSITIONS AND METHODS FOR MODULATING INFLAMMATORY AND DEGENERATIVE DISORDER
  申请人：University of Southern California

  公开号：US20200377494A1

  公开（公告）日：2020-12-03

  The disclosure provides compounds and method useful for modulating gp130 biological activity. The disclosure also provides methods and compositions for treating disease and disorders associated with gp130 activity, particularly those associated with inflammation.
• [EN] SMALL MOLECULE MODULATORS OF GP130 SIGNALING PATHWAYS, TOPICAL FORMULATIONS AND METHOD OF US THEREOF<br/>[FR] MODULATEURS À PETITES MOLÉCULES DE VOIES DE SIGNALISATION GP130, FORMULATIONS TOPIQUES ET LEUR PROCÉDÉ D'UTILISATION
  申请人：[en]CARTHRONIX, INC.

  公开号：WO2022082071A1

  公开（公告）日：2022-04-21

  Disclosed herein are small molecule modulators, compositions, formulations, and methods of use of a novel skin care treatment.