1-乙氧基-2,3-二甲基苯 | 61808-02-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-乙氧基-2,3-二甲基苯
• 英文名称: 2,3-dimethyl-phenetole
• 英文别名: Aethyl-vic.-o-xylenyl-aether；vic.-o-Xylenol-aethylaether；2,3-Dimethyl-phenetol；3-Aethoxy-o-xylol；Aethyl-(2.3-dimethyl-phenyl)-aether；3-Aethoxy-1.2-dimethyl-benzol；1-Ethoxy-2,3-dimethylbenzene
• CAS: 61808-02-4
• 化学式: C₁₀H₁₄O
• mdl: MFCD28096652
• 分子量: 150.221
• InChiKey: ZLDYMRPAVGESMU-UHFFFAOYSA-N

物化性质

• 沸点：
  208-210 °C
• 密度：
  0.924±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-环戊烯羧酸 、 1-乙氧基-2,3-二甲基苯 在 PPA 、 Polyphosphoric acid (PPA) 作用下， 反应 3.0h， 以50%的产率得到(3aS,8bR)-7-ethoxy-5,6-dimethyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[a]inden-4-one
  参考文献：
  名称：

  Waghulde, Vidyullata C.; Merchant, Jaysukhlal R., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1989, vol. 28, # 1-11, p. 419 - 421

  摘要：

  DOI：
• 作为产物：
  描述：

  水 生成 1-乙氧基-2,3-二甲基苯
  参考文献：
  名称：

  BATES, ROBERT B.;SIAHAAN, TERUNA J.;SUVANNACHUT, KESSARA, J. ORG. CHEM., 55,(1990) N, C. 1328-1334

  摘要：

  DOI：

文献信息

• N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
  申请人：BRANCH Clive Leslie

  公开号：US20080318944A1

  公开（公告）日：2008-12-25

  Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.

  本发明涉及具有以下公式的N-芳酰基环氨基衍生物：其中变量如本文所定义，并且它们作为药物的用途，特别是作为促进睡眠的药物。
• N-AROYL CYCLIC AMINES
  申请人：BRANCH Clive Leslie

  公开号：US20090029986A1

  公开（公告）日：2009-01-29

  Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.

  揭示了具有以下公式的N-芳酰基环状胺衍生物： 其中取代基变量如此定义，并且它们作为药物的用途。
• 8-AZAPROSTAGLANDIN DERIVATIVE COMPOUND AND AGENT COMPRISING THE COMPOUND AS ACTIVE INGREDIENT
  申请人：TANI Kousuke

  公开号：US20090042885A1

  公开（公告）日：2009-02-12

  An 8-azaprostaglandin represented by formula (I) (wherein all symbols have the same meanings as described in the specification), a pharmaceutically acceptable salt thereof or a cyclodextrin clathrate thereof. Since the compound represented by formula (I) binds to EP2 subtype among PGE receptor strongly, it is useful for preventive and/or treatment for immune diseases, allergic diseases, neuronal cell death, dysmenorrhea, premature birth, abortion, baldness, retinal neuropathy such as glaucoma, erectile dysfunction, arthritis, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, hepatic injury, acute hepatitis, liver cirrhosis, shock, nephritis, renal failure, circulatory diseases, systemic inflammatory response syndrome, sepsis, hemophagocytosis syndrome, macrophage activation syndrome, still disease, Kawasaki Disease, burn, systemic granuloma, ulcerative colitis, Crohn disease, hypercytokinemia at dialysis, multiple organ failure, or bone diseases etc.

  式（I）所表示的8-氮代前列腺素化合物（其中所有符号的含义与说明书中描述的相同），其药学上可接受的盐或环糊精包合物。由于式（I）所表示的化合物强烈结合到PGE受体中的EP2亚型，因此它对预防和/或治疗免疫性疾病、过敏性疾病、神经元细胞死亡、痛经、早产、流产、脱发、青光眼等视网膜神经病变、勃起功能障碍、关节炎、肺损伤、肺纤维化、肺气肿、支气管炎、慢性阻塞性肺疾病、肝损伤、急性肝炎、肝硬化、休克、肾炎、肾衰竭、循环系统疾病、全身炎症反应综合征、败血症、吞噬细胞综合征、巨噬细胞活化综合征、斯蒂尔病、川崎病、烧伤、全身性肉芽肿、溃疡性结肠炎、克罗恩病、透析时的高细胞因子血症、多器官功能障碍或骨疾病等方面具有用处。
• Aralkylphenolic resin molding material
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0284385A2

  公开（公告）日：1988-09-28

  An aralkylphenolic resin molding material comprises an aralkylphenolic resin prepared by reacting a compound represented by the general formula (I) with a phenolic compound, mountain leather and optionally glass fiber being incorporated in the resin as inorganic filler materials. The aralkylphenolic resin molding material contains no asbestos but has equal or better characteristics as compared with molding materials containing asbestos. In particular the present aralkylphenolic resin has excellent heat resistance, mechanical characteristics and electrical characteristics.

  一种芳基酚醛树脂成型材料包括一种芳基酚醛树脂，由通式 (I) 所代表的化合物与酚类化合物反应制备而成。 山皮和玻璃纤维作为无机填充材料加入树脂中。 这种芳基酚醛树脂模塑材料不含石棉，但与含石棉的模塑材料相比，具有相同或更好的特性。尤其是本产品的芳基酚醛树脂具有极佳的耐热性、机械特性和电气特性。
• 1-[2-(heterocyclyl-aminomethyl)-piperidin-1-YL]-1-(2-methyl-5-phenyl-heterocyclyl)-methanone derivatives and related compounds as orexin-1 antagonists for the treatment of obesity
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1956020A2

  公开（公告）日：2008-08-13

  This invention relates to N-aroyl cyclic amine derivatives and their use as pharmaceuticals.

  本发明涉及 N-芳酰基环胺衍生物及其作为药物的用途。