1-异丙氧基-4-异丙氧基甲基苯 | 100532-72-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-异丙氧基-4-异丙氧基甲基苯
• 英文名称: 1-isopropoxy-4-isopropoxymethyl-benzene
• 英文别名: 1-Isopropoxy-4-isopropoxymethyl-benzol；1-Propan-2-yloxy-4-(propan-2-yloxymethyl)benzene
• CAS: 100532-72-7
• 化学式: C₁₃H₂₀O₂
• 分子量: 208.301
• InChiKey: ZTNNPZLWVLYNJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对羟基苯甲醇 、 异丙醇 在 sodium hydrogen sulfate 、 silica gel 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以92%的产率得到(4-isopropoxymethyl)phenol
  参考文献：
  名称：

  Silica‐Supported Sodium Hydrogen Sulfate Catalyzed Facile Transformation ofp‐Hydroxybenzyl Alcohols top‐Hydroxybenzyl Ethers and Thioethers

  摘要：

  The heterogeneous catalyst, silica-supported sodium hydrogen sulfate (NaHSO4 - SiO2) has been found to be highly efficient in carrying out the transformation of p-hydroxybenzyl alcohols at room temperature to p-hydroxybenzyl ethers and thioethers in very high yields.

  DOI：

  10.1081/scc-200028584

文献信息

• Non-chromatographic purification of macrocyclic peptides by a resin catch and release
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US11479581B2

  公开（公告）日：2022-10-25

  The disclosure is directed to compounds and methods for preparing purified macrocyclic peptide using “catch-release” methods. These methods comprise reacting a free amino group of a resin-bound linear peptide with an azide- or alkyne-functionalized cap to form a resin-bound capped linear peptide having an azide- or alkyne-functionalized cap; cleaving the capped linear peptide from the resin to form a free capped linear peptide having an azide- or alkyne-functionalized cap; reacting the free capped linear peptide having an azide-functionalized cap with an alkyne-functionalized catch resin, or reacting the free capped linear peptide having an akynyl-functionalized cap with an azide functionalized catch resin, to form a catch-resin bound capped linear peptide; reacting the catch-resin bound capped linear peptide under conditions sufficient to effect macrocyclization of the linear peptide and release of the macrocyclic peptide from the catch resin.

  本公开涉及使用 "捕获-释放 "方法制备纯化大环肽的化合物和方法。这些方法包括：使树脂结合的线性肽的游离氨基与叠氮或烷基官能化帽反应，形成具有叠氮或烷基官能化帽的树脂结合封帽线性肽；将封帽线性肽从树脂中裂解，形成具有叠氮或烷基官能化帽的游离封帽线性肽；将具有叠氮官能化帽的游离封端线性肽与炔官能化捕捉树脂反应，或将具有炔官能化帽的游离封端线性肽与叠氮官能化捕捉树脂反应，形成捕捉树脂结合的封端线性肽；在足以使线性肽大环化和大环肽从捕捉树脂中释放的条件下，反应捕捉树脂结合的封端线性肽。
• PROBES FOR RAPID AND SPECIFIC DETECTION OF MYCOBACTERIA
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20170044593A1

  公开（公告）日：2017-02-16

  The compositions of the present disclosure provide novel fluorogenic probes for use in the specific imaging and detection of mycobacteria species, and in particular β-lactam-antibiotic resistant. Specificity for mycobacteria is conferred on these probes by incorporating a moiety that specifically targets the unique trapping mechanism of the DprE1 found in in mycobacteria. Accordingly, only Mycobacteria species that express both a β-lactamase and DprE1 enable both the activation of the caged fluorescent probe, and the affixing of the released fluorescent probes to the bacteria cells through the functioning reduction-covalent binding mechanism. Advantageously, such a probe is able, at its most sensitive, to allow single mycobacterium detection.
• LIPID PRODRUGS OF MYCOPHENOLIC ACID AND USES THEREOF
  申请人：PureTech LYT, Inc.

  公开号：US20200390777A1

  公开（公告）日：2020-12-17

  The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
• NON-CHROMATOGRAPHIC PURIFICATION OF MACROCYCLIC PEPTIDES BY A RESIN CATCH AND RELEASE
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20210079046A1

  公开（公告）日：2021-03-18

  The disclosure is directed to compounds and methods for preparing purified macrocyclic peptide using “catch-release” methods. These methods comprise reacting a free amino group of a resin-bound linear peptide with an azide- or alkyne-functionalized cap to form a resin-bound capped linear peptide having an azide- or alkyne-functionalized cap; cleaving said capped linear peptide from the resin to form a free capped linear peptide having an azide- or alkyne-functionalized cap; reacting the free capped linear peptide having an azide-functionalized cap with an alkyne-functionalized catch resin, or reacting the free capped linear peptide having an akynyl-functionalized cap with an azide functionalized catch resin, to form a catch-resin bound capped linear peptide; reacting the catch-resin bound capped linear peptide under conditions sufficient to effect macrocyclization of the linear peptide and release of the macrocyclic peptide from the catch resin.
• LIPID PRODRUGS OF NEUROSTEROIDS
  申请人：PureTech LYT, Inc.

  公开号：US20220395513A1

  公开（公告）日：2022-12-15

  The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.