1-氨基-4,6-二苯基-1,2-二氢吡啶-2-酮 | 26478-97-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 1-氨基-4,6-二苯基-1,2-二氢吡啶-2-酮
• 英文名称: 1-amino-4,6-diphenyl-2-pyridone
• 英文别名: 1-Amino-4,6-diphenyl-2-pyridon；1-Amino-4,6-diphenyl-1,2-dihydropyridin-2-one；1-amino-4,6-diphenylpyridin-2-one
• CAS: 26478-97-7
• 化学式: C₁₇H₁₄N₂O
• 分子量: 262.311
• InChiKey: KSPKRQXZWKVDKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090

SDS

Name:	1-Amino-4 6-diphenyl-1 2-dihydropyridin-2-one tech Material Safety Data Sheet
Synonym:	1-Amino-4,6-diphenyl-2-pyridon
CAS:	26478-97-7

Section 1 - Chemical Product MSDS Name:1-Amino-4 6-diphenyl-1 2-dihydropyridin-2-one tech Material Safety Data Sheet
Synonym:1-Amino-4,6-diphenyl-2-pyridon

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
26478-97-7	1-Amino-4,6-diphenyl-1,2-dihydropyridi	97%	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 26478-97-7: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: off-white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 164 - 166 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C17H14N2O
Molecular Weight: 262

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Acids, strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 26478-97-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
1-Amino-4,6-diphenyl-1,2-dihydropyridin-2-one - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 26478-97-7: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 26478-97-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 26478-97-7 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  1-氨基-4,6-二苯基-1,2-二氢吡啶-2-酮 在 溴 、 三乙胺 作用下， 以 苯 为溶剂， 反应 24.0h， 生成 5,7-diphenyl-1,3,4-oxadiazolo<3,2-a>pyridilium-2-thiolate
  参考文献：
  名称：

  Molina, Pedro; Alajarin, Mateo; Arques, Antonio, Journal of the Chemical Society. Perkin transactions I, 1982, p. 351 - 356

  摘要：

  DOI：
• 作为产物：
  描述：

  1-[[3-(dimethylamino)-1-(4-methylphenyl)prop-2-enylidene]amino]-4,6-diphenylpyridin-2-one 在 盐酸 、 盐酸羟胺 、 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 6.0h， 生成 1-氨基-4,6-二苯基-1,2-二氢吡啶-2-酮
  参考文献：
  名称：

  Molina, P.; Fresneda, P. M., Journal of Heterocyclic Chemistry, 1984, vol. 21, p. 461 - 464

  摘要：

  DOI：
• 作为试剂：
  描述：

  苯基丙醇水合物 在 1-氨基-4,6-二苯基-1,2-二氢吡啶-2-酮 作用下， 以 甲苯 为溶剂， 反应 6.0h， 以97%的产率得到苯甲酰腈
  参考文献：
  名称：

  A Convenient One-Step Synthesis of Aroyl Cyanides from Arylglyoxals or Phenacyl Bromides

  摘要：

  DOI：

  10.1055/s-1980-29233

文献信息

• [EN] SUBSTITUTED 1H-PYRIDINE-2-ONE DERIVATIVES<br/>[FR] DERIVES DE 1H-PYRIDINE-2-ONE SUBSTITUEE
  申请人：C & C RES LAB

  公开号：WO2004050624A1

  公开（公告）日：2004-06-17

  The present invention relates to substituted 1H-pyridine-2-one derivatives of formula (1) and pharmaceutically acceptable salts thereof, which are useful for the treatment of chronic obstructive pulmonary disease, asthma, chronic bronchitis, psoriasis, ulcerative colitis, Crohn's disease (local ileitis), arteriosclerosis, rheumatoid arthritis, osteoporosis, bone arthritis, depression, memory loss, inflammation mediated by chronic necrosis and the others mediated by PDE4: (I)

  本发明涉及式（1）的取代1H-吡啶-2-酮衍生物及其药学上可接受的盐，用于治疗慢性阻塞性肺疾病、哮喘、慢性支气管炎、牛皮癣、溃疡性结肠炎、克罗恩病（局部回肠炎）、动脉硬化、类风湿性关节炎、骨质疏松症、骨关节炎、抑郁症、记忆力丧失、由慢性坏死介导的炎症以及其他由PDE4介导的炎症：（I）
• Preparation of fused meso-ionic compounds from 1-amino-4,6-diphenyl-2-pyridone
  作者：M. Alajarín、P. Molina

  DOI：10.1016/s0040-4039(00)92861-2

  日期：1980.1

  A number of meso-ionic compounds derivatives of the bicyclic system 1,3,4-oxadiazolo[3,2-a]pyridine have been prepared from 1-amino-4,6-diphenyl-2-pyridone, either by thermal way or iminophosphorane ()

  由1-氨基-4,6-二苯基-2-吡啶酮通过热法或热解法制得了许多双环体系1,3,4-恶二唑并[3,2-a]吡啶的中离子化合物衍生物。亚氨基磷烷（）
• Activity againstTrypanosoma cruzi of New Analogues of Nifurtimox
  作者：B. Mester、J. Elguero、R. M. Claramunt、S. Castanys、M. L. Mascaró、A. Osuna、M. J. Vilaplana、P. Molina

  DOI：10.1002/ardp.19873200205

  日期：——

  Ten new derivatives 1 structurally related to Nifurtimox have been synthesized from 5‐nitrofurfural and the corresponding N‐aminoheterocyclic compounds. Physical data, spectroscopic characteristics and biological properties have been examined. An unusual long‐range coupling constant in the pyrazolyl derivative 1b has been observed. Compounds in which the heterocyclic counterparts are 1,2,4‐triazol‐4‐yl

  由 5-硝基糠醛和相应的 N-氨基杂环化合物合成了十种与 Nifurtimox 结构相关的新衍生物 1。已检查物理数据、光谱特性和生物学特性。在吡唑基衍生物 1b 中观察到了一个不寻常的长程耦合常数。其中杂环对应物为 1,2,4-triazol-4-yl 和 pyridin-1-yl 基团的化合物清楚地显示出对克氏锥虫的优越活性。
• An Efficient Regioselective Synthesis of 2,4-Diarylfurans
  作者：P. Molina、A. Lorenzo、P. M. Fresneda

  DOI：10.1055/s-1983-30218

  日期：——
• A New Direct Synthesis of Derivatives of the <i>s</i>-Triazolo[1,5-<i>a</i>]pyridine Ring System
  作者：P. Molina、A. Tárraga、C. Martínez

  DOI：10.1055/s-1982-30031

  日期：——