1-溴-2-萘丁醛 | 159305-83-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1-溴-2-萘丁醛
• 英文名称: 1-Bromo-2-naphthalenebutanal
• 英文别名: 4-(1-Bromonaphthalen-2-yl)butanal
• CAS: 159305-83-6
• 化学式: C₁₄H₁₃BrO
• 分子量: 277.161
• InChiKey: BSQRVUYTVZKILO-UHFFFAOYSA-N

物化性质

• 沸点：
  401.5±28.0 °C(Predicted)
• 密度：
  1.366±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-溴-2-萘丁醛 在 吡啶 、 偶氮二异丁腈 、 盐酸羟胺 、 三正丁基氢锡 、 copper(II) sulfate 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 、 水 、 苯 为溶剂， 反应 13.0h， 生成 2-naphthalenebutanenitrile
  参考文献：
  名称：

  Enediyne- and Tributyltin Hydride-Mediated Aryl Radical Additions onto Various Radical Acceptors

  摘要：

  Tandem enediyne-radical cyclizations were carried out on substrates that contain nitrile and ketone radical accepters. The products of these cyclizations and the previously reported tandem enediyne-radical cyclizations containing aldehyde and oxime ether radical accepters were compared with tributyltin hydride-mediated aryl radical addition reactions with 1-bromonaphthalene derivatives containing aldehyde, oxime ether, nitrile, and ketone radical accepters, since these substrates go through similar initial radical intermediates. Although many of the same products were observed using either method of aryl radical generation, there were distinct differences in the product composition and identity depending on which method was used. These differences can probably be primarily attributed to the temperature difference of the two modes of radical generation.

  DOI：

  10.1021/jo00104a053
• 作为产物：
  描述：

  1-bromo-2-(3-butenyl)naphthalene 在 sodium hydroxide 、 9-borabicyclo[3.3.1]nonane dimer 、 双氧水 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 8.42h， 生成 1-溴-2-萘丁醛
  参考文献：
  名称：

  Enediyne- and Tributyltin Hydride-Mediated Aryl Radical Additions onto Various Radical Acceptors

  摘要：

  Tandem enediyne-radical cyclizations were carried out on substrates that contain nitrile and ketone radical accepters. The products of these cyclizations and the previously reported tandem enediyne-radical cyclizations containing aldehyde and oxime ether radical accepters were compared with tributyltin hydride-mediated aryl radical addition reactions with 1-bromonaphthalene derivatives containing aldehyde, oxime ether, nitrile, and ketone radical accepters, since these substrates go through similar initial radical intermediates. Although many of the same products were observed using either method of aryl radical generation, there were distinct differences in the product composition and identity depending on which method was used. These differences can probably be primarily attributed to the temperature difference of the two modes of radical generation.

  DOI：

  10.1021/jo00104a053