COATED MAGNETIC PARTICLE CONTAINING PREPARATION, PROCESS FOR PRODUCING THE SAME AND DIAGNOSTIC THERAPEUTIC SYSTEM
申请人:Konica Minolta Medical & Graphic, Inc.
公开号:EP1842554A1
公开(公告)日:2007-10-10
It is an object of the invention to provide a pharmaceutical preparation containing magnetic vesicular particles which enables selective delivery of agents to a tumor site (targeting capability), is applicable to a contrast medium material or drug transport carrier and is also usable in thermotherapy employing heat-generation, and diagnosis and treatment of cancer by combinations thereof, and further a manufacturing method thereof and a diagnostic therapeutic system by use thereof.
There is disclosed a pharmaceutical preparation comprising magnetic vesicular particles, wherein the magnetic vesicular particles each include one or more magnetic microparticles within a lipid membrane, the magnetic microparticle having particulate gold attached to the surface of the magnetic microparticles and further having an organic compound bound to the particulate gold; and the vesicular particles meet the following requirement:
wherein R is an average particle size of the magnetic vesicular particles and r is an average particle size of the magnetic microparticles included in the magnetic vesicular particles.
本发明的目的是提供一种含有磁性囊状微粒的药物制剂,该药物制剂可选择性地将药剂输送到肿瘤部位(靶向能力),适用于造影剂材料或药物运输载体,也可用于热疗(利用发热),以及通过其组合诊断和治疗癌症,并进一步提供其制造方法和利用其制造的诊断治疗系统。
本发明公开了一种药物制剂,该药物制剂包括磁性囊状颗粒,其中磁性囊状颗粒包括脂膜中的一个或多个磁性微粒,磁性微粒表面附着有微粒金,微粒金上还结合有有机化合物;囊状颗粒符合以下要求:
其中 R 是磁性囊状颗粒的平均粒径,r 是磁性囊状颗粒中包含的磁性微粒的平均粒径。