1-甲基-4-[(4-硝基苯基)甲氧基]苯 | 67565-47-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-甲基-4-[(4-硝基苯基)甲氧基]苯
• 英文名称: 4-methylphenyl 4-nitrobenzyl ether
• 英文别名: 4-nitrobenzyl 4-methylphenyl ether；(4-nitro-benzyl)-p-tolyl ether；(4-Nitro-benzyl)-p-tolyl-aether；(4-Nitrobenzyl)-(4-methylphenyl)-ether；4-Nitro-benzyl-p-tolyl-ether；p-Nitrobenzyl-p-tolylether；4-(4-Nitrobenzyloxy)benzyl；1-methyl-4-[(4-nitrophenyl)methoxy]benzene
• CAS: 67565-47-3
• 化学式: C₁₄H₁₃NO₃
• mdl: MFCD00434343
• 分子量: 243.262
• InChiKey: OCEGGGPJZUQJSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-甲基-4-[(4-硝基苯基)甲氧基]苯 在 盐酸 、 溶剂黄146 、 tin(ll) chloride 作用下， 生成 4-methylphenyl 4-aminobenzyl ether
  参考文献：
  名称：

  Pummerer; Melamed; Puttfarcken, Chemische Berichte, 1922, vol. 55, p. 3130

  摘要：

  DOI：
• 作为产物：
  描述：

  对甲酚 、 1-(氯甲基)-4-硝基苯 在 cesium fluoride 作用下， 以 乙腈 为溶剂， 以92%的产率得到1-甲基-4-[(4-硝基苯基)甲氧基]苯
  参考文献：
  名称：

  氟化铯-Celite：有效合成芳族酯和醚的固体基础

  摘要：

  描述了许多芳族和杂芳族酚与烷基，酰基或苯甲酰卤在乙腈中与氟化铯-硅藻土的偶联反应，表明该试剂为合成芳族酯和醚提供了一种有效，方便和实用的方法。

  DOI：

  10.1016/j.tet.2005.03.126

文献信息

• Synthesis of Aromatic Ethers Without Organic Solvent and Inorganic Carrier under Microwave Irradiation
  作者：Jin-Xian Wang、Manli Zhang、Zhiliang Xing、Yulai Hu

  DOI：10.1080/00397919608003618

  日期：1996.1

  Abstract A simple, repid and efficient procedure for the synthesis of aromatic ethers via microwave irradiation without any organic solvent and inorganic carrier is reported.

  摘要 报道了一种无需任何有机溶剂和无机载体的微波辐射合成芳香醚的简单、快速、高效的方法。
• POLYMER GEL AND PROCESS FOR THE ACTIVATION OF ACTIVE HYDROGEN COMPOUNDS
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP0970937A1

  公开（公告）日：2000-01-12

  Active hydrogen in an active-hydrogen-containing compound is activated by using a polymer gel having a three-dimensional network structure holding a solvent inside thereof and active sites inside the three-dimensional network structure and surfaces thereof. The ratio of swell of the polymer gel is preferably set to not less than 2, and it is preferable for the polymer gel to have a basic functional group derived from at least one compound selected from the group consisting of tertiary amine compounds, quaternary ammonium salts, cyclic amine compounds and sulfides. The activation of active hydrogen in the active-hydrogen-containing compound is preferably carried out under the condition that the amount of basic active sites of the polymer gel per unit volume in the active system accompanying the activation of active hydrogen is set to not less than 0.43 mmol/cc.

  使用聚合物凝胶激活含活性氢化合物中的活性氢，该聚合物凝胶具有三维网络结构，在其内部容纳溶剂，在三维网络结构内部及其表面具有活性位点。聚合物凝胶的溶胀比最好不小于 2，聚合物凝胶最好具有一个碱性官能团，该官能团至少来自一种选自叔胺化合物、季铵盐、环胺化合物和硫化物的化合物。含活性氢化合物中活性氢的活化最好是在以下条件下进行：伴随活性氢活化的活性体系中每单位体积聚合物凝胶的碱性活性位点量设定为不低于 0.43 mmol/cc。
• High polymer gel and activation method for compounds containing active hydrogen
  申请人：Nippon Shokubai Co., Ltd.

  公开号：US20020028872A1

  公开（公告）日：2002-03-07

  Active hydrogen in an active-hydrogen-containing compound is activated by using a polymer gel having a three-dimensional network structure holding a solvent inside thereof and active sites inside the three-dimensional network structure and surfaces thereof. The ratio of swell of the polymer gel is preferably set to not less than 2, and it is preferable for the polymer gel to have a basic functional group derived from at least one compound selected from the group consisting of tertiary amine compounds, quaternary ammonium salts, cyclic amine compounds and sulfides. The activation of active hydrogen in the active-hydrogen-containing compound is preferably carried out under the condition that the amount of basic active sites of the polymer gel per unit volume in the active system accompanying the activation of active hydrogen is set to not less than 0.43 mmol/cc.

  使用聚合物凝胶激活含活性氢化合物中的活性氢，该聚合物凝胶具有三维网络结构，在其内部容纳溶剂，在三维网络结构内部及其表面具有活性位点。聚合物凝胶的溶胀比最好不小于 2，聚合物凝胶最好具有一个碱性官能团，该官能团至少来自一种选自叔胺化合物、季铵盐、环胺化合物和硫化物的化合物。含活性氢化合物中活性氢的活化最好是在以下条件下进行：伴随活性氢活化的活性体系中每单位体积聚合物凝胶的碱性活性位点量设定为不低于 0.43 mmol/cc。
• Electron apportionment in cleavage of radical anions. 1. Nitro-substituted benzyl phenyl ethers
  作者：Przemyslaw. Maslak、Robert D. Guthrie

  DOI：10.1021/ja00270a021

  日期：1986.5
• Powell; Adams, Journal of the American Chemical Society, 1920, vol. 42, p. 655
  作者：Powell、Adams

  DOI：——

  日期：——