α -Hydroxydimethylacetals I have been shown to undergo two different rearrangements involving highly selective 1,2-shifts under mild conditions. When treated with Ph3P/CCl4, in the presence of pyridine, I were cleanly transformed via 1,2-aryl shifts into methyl 2-arylpropanoates, an important class of anti-inflammatory agents; a pronounced substituent effect has been observed in this rearrangement
已经显示出α-羟基二甲基
乙缩醛I在温和条件下经历了两种不同的重排,包括高度选择性的1,2-移位。当用Ph 3 P / CCl 4处理时,在
吡啶的存在下,I通过1,2-芳基转移干净地转化为重要的一类抗炎药2-芳基
丙酸甲酯;在这种重排中观察到明显的取代作用。