1-甲氧基-4-[4-(2-甲基丙基)苯基]苯 | 644964-53-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-甲氧基-4-[4-(2-甲基丙基)苯基]苯
• 英文名称: 4'-isobutyl-1,1'-biphenyl-4-yl methyl ether
• 英文别名: 1,1'-Biphenyl, 4-methoxy-4'-(2-methylpropyl)-；1-methoxy-4-[4-(2-methylpropyl)phenyl]benzene
• CAS: 644964-53-4
• 化学式: C₁₇H₂₀O
• 分子量: 240.345
• InChiKey: MEYBLUDQFTZTPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  bromozinc(1+),2-methylpropane 、 alkaline earth salt of/the/ methylsulfuric acid 以 四氢呋喃 为溶剂， 生成 1-甲氧基-4-[4-(2-甲基丙基)苯基]苯
  参考文献：
  名称：

  Tunable Unsymmetrical Ferrocene Ligands Bearing a Bulky Di-1-adamantylphosphino Motif for Many Kinds of C_sp²–C_sp³ Couplings

  摘要：

  DOI：

  10.1021/acscatal.2c00352

文献信息

• Polymer-Assisted Solution-Phase (PASP) Suzuki Couplings Employing an Anthracene-Tagged Palladium Catalyst
  作者：Ping Lan、Daniela Berta、John A. Porco、Michael S. South、John J. Parlow

  DOI：10.1021/jo035129g

  日期：2003.12.1

  A general method for polymer-assisted solution-phase (PASP) Suzuki reactions employing a combination of anthracene-tagged palladium catalyst and anthracene-tagged boronic acid with a polymer-supported carbonate base is reported. The anthracene-tagged catalyst allows for the easy removal of the Pd catalyst along with the dissociated phosphine ligand and phosphine oxide byproducts by sequestration through a chemoselective Diels-Alder reaction with a maleimide resin. The polymer-supported carbonate base facilitates the removal of excess boronic acid and the borane-containing byproducts present at the end of the coupling reaction. The Suzuki coupling reaction can be efficiently conducted by using combinations of the anthracene-tagged Pd catalyst, polymer-supported carbonate base, and anthracene-tagged boronic acid to yield the desired product in high purity and yield without the use of chromatography.
• BICYCLIC IMIDAZOLO DERIVATIVE
  申请人：Sumitomo Dainippon Pharma Co., Ltd.

  公开号：US20180044343A1

  公开（公告）日：2018-02-15

  Disclosed are compounds, having the following structure, useful as inhibitors of Phosphodiesterase 1 (PDE1), compositions comprising the compounds, and methods of using the same.
• Tunable Unsymmetrical Ferrocene Ligands Bearing a Bulky Di-1-adamantylphosphino Motif for Many Kinds of C_sp²–C_sp³ Couplings
  作者：Guolin Xu、Peng Gao、Thomas J. Colacot

  DOI：10.1021/acscatal.2c00352

  日期：2022.5.6