1-羟基十八烷-3-酮 | 10575-28-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 1-羟基十八烷-3-酮
• 英文名称: 1-hydroxy-3-octadecanone
• 英文别名: 1-Hydroxy-octadecan-3-on；1-hydroxy-octadecan-3-one；1-Hydroxyoctadecan-3-one
• CAS: 10575-28-7
• 化学式: C₁₈H₃₆O₂
• 分子量: 284.483
• InChiKey: GUXGPSBHTJHEQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  20
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-羟基十八烷-3-酮 生成 十六碳酰胺
  参考文献：
  名称：

  Pinacol Deamination Rearrangement of Dihydrosphingosine¹

  摘要：

  DOI：

  10.1021/jo01344a538
• 作为产物：
  描述：

  D-鞘氨醇 生成 1-羟基十八烷-3-酮
  参考文献：
  名称：

  Pinacol Deamination Rearrangement of Dihydrosphingosine¹

  摘要：

  DOI：

  10.1021/jo01344a538

文献信息

• ARTIFICIALLY SYNTHESIZED SPHINGOSINE DERIVATIVE LIPOID MONOMER AND USE OF SAME FOR DELIVERING NUCLEIC ACID
  申请人：Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

  公开号：EP3777891A1

  公开（公告）日：2021-02-17

  Provided are an artificially synthesized sphingosine lipoid monomer and the use of same for delivering a nucleic acid. In particular, provided is the use or a method of using a compound of formula I, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, or a combination comprising the compound of formula I, the stereoisomer thereof or the pharmaceutically acceptable salt thereof to deliver a nucleic acid to a cell or subject, (I)

  本发明提供了一种人工合成的鞘氨醇类脂质单体及其用于递送核酸的用途。特别是，提供了使用式 I 的化合物、其立体异构体或其药学上可接受的盐，或包含式 I 的化合物、其立体异构体或其药学上可接受的盐的组合物向细胞或受试者递送核酸的用途或方法，(I)
• DETECTION OF PRETERM LABOUR
  申请人：THE UNIVERSITY OF LEICESTER

  公开号：EP1723433A2

  公开（公告）日：2006-11-22
• EPITOPE REDUCTION THERAPY
  申请人：Crispin Matthew David Max

  公开号：US20100022620A1

  公开（公告）日：2010-01-28

  The present invention provides the use of an inhibitor of glycolipid biosynthesis in the manufacture of a medicament for the treatment of a glycolipid-mediated autoimmune disease.
• [EN] DETECTION OF PRETERM LABOUR<br/>[FR] DETECTION D'UN ACCOUCHEMENT PREMATURE
  申请人：UNIV LEICESTER

  公开号：WO2005085873A2

  公开（公告）日：2005-09-15

  The invention describes a method for diagnosis of preterm labour in a mammal, comprising measuring levels of an endocannabinoid such as anandamide in a subject. Elevated levels are indicate of preterm labour. The measurement is typically performed during late pregnancy, such as the third trimester in humans. In certain embodiments, endocannabinoid levels may be measured indirectly, for example by measurement of fatty acid amide hydrolase (FAAH) levels.