1-苄基-4-缩水甘油酯哌嗪 | 335165-57-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-苄基-4-缩水甘油酯哌嗪
• 英文名称: benzyl-4-(2,3-epoxypropyl)-piperazine
• 英文别名: 1-benzyl-4-oxiranylmethyl-piperazine；(+/-)-1-Benzyl-4-oxiranylmethyl-piperazine；1-(2,3-Epoxypropyl)-4-benzylpiperazin；1-Benzyl-4-glycidylpiperazine；1-benzyl-4-(oxiran-2-ylmethyl)piperazine
• CAS: 335165-57-6
• 化学式: C₁₄H₂₀N₂O
• mdl: MFCD09803291
• 分子量: 232.326
• InChiKey: BMBBIQDCHKBYNH-UHFFFAOYSA-N

物化性质

• 沸点：
  340.8±22.0 °C(Predicted)
• 密度：
  1.134±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  19
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(1H-pyrrol-1-yl)-1H-purine 、 1-苄基-4-缩水甘油酯哌嗪 在 四丁基氟化铵 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 4.0h， 以4.3 g的产率得到1-(4-Benzylpiperazin-1-yl)-3-(6-pyrrol-1-ylpurin-9-yl)propan-2-ol
  参考文献：
  名称：

  Synthesis and Structure-Activity Relationships of 6-Heterocyclic-Substituted Purines as Inactivation Modifiers of Cardiac Sodium Channels

  摘要：

  Purine-based analogs of SDZ 211-500 (5) were prepared and evaluated as inactivation modifiers of guinea pig or human cardiac sodium (Na) channels expressed in Xenopus oocytes. Substances which remove or slow the Na channel inactivation process in cardiac tissue are anticipated to prolong the effective refractory period and increase inotropy and thus have potential utility as antiarrhythmic agents. Heterocyclic substitution at the 6-position of the purine ring resulted in compounds with increased Na activity and potency, with 5-membered heterocycles being optimal. Only minor modifications to the benzhydrylpiperazine side chain were tolerated. Selected compounds which delayed the inactivation of Na channels were found to increase refractoriness and contractility in a rabbit Langendorff heart model, consistent with the cellular mechanism. Activity in both the oocyte and rabbit heart assays was specific to the S enantiomers. Preliminary in vivo activity has been demonstrated following intravenous infusion. The most promising compound on the basis of in vitro data is the formylpyrrole (S)-74, which is 25-fold more potent than DPI 201-106 (1) in the human heart Na channel assay.

  DOI：

  10.1021/jm00014a011
• 作为产物：
  描述：

  1-苄基哌嗪 、 环氧溴丙烷 在 potassium carbonate 作用下， 以 甲醇 、 2-氨基-3-氯-1,4-萘醌 为溶剂， 以84%的产率得到1-苄基-4-缩水甘油酯哌嗪
  参考文献：
  名称：

  9-(Piperazinylalkyl)carbazoles as Bax-modulators

  摘要：

  本发明涉及哌嗪衍生物的咔唑，特别用作药用活性化合物，以及含有这种哌嗪衍生物的咔唑的药物配方。所述的哌嗪衍生物的咔唑是有效的调节剂，特别是Bax功能和/或激活的抑制剂。本发明还涉及新型哌嗪衍生物的咔唑以及其制备方法。

  公开号：

  EP1094063A1

文献信息

• [EN] 9- (PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS<br/>[FR] 9- (PIPERAZINYLALKYL) CARBAZOLES UTILES EN TANT QUE MODULATEURS DE BAX
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2001029028A1

  公开（公告）日：2001-04-26

  The present invention is related to piperazine derivatives of carbazole of formula (I) notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such piperazine derivatives of carbazole. Said piperazine derivatives of carbazole are efficient modulators, in particular efficient inhibitors, of the Bax function and/or activation. The present invention is furthermore related to novel piperazine derivatives of carbazole as well as methods of their preparation.

  本发明涉及式(I)的嘧啶二酰胺衍生物，特别是作为药物活性化合物的使用，以及含有这种嘧啶二酰胺衍生物的制药配方。所述嘧啶二酰胺衍生物是高效的调节剂，特别是高效的抑制剂，对Bax功能和/或激活具有作用。本发明还涉及新的嘧啶二酰胺衍生物以及其制备方法。
• 9-(PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS
  申请人：HALAZY Serge

  公开号：US20120040933A1

  公开（公告）日：2012-02-16

  piperazine compounds for use as pharmaceutically active compounds and in pharmaceutical formulations that are useful for the treatment of disorders associated with apoptosis, including neurodegenerative disorders, diseases associated with polyglutamine tracts, epilepsy, ischemia, infertility, cardiovascular disorders, renal hypoxia, hepatitis and AIDS, where the piperazine compounds are represented by formula (I) and the terms R 0 , R 1 , R 2 , R 3 , k, l, m, n, and X are defined herein:

  使用哌嗪化合物作为药物活性化合物和制药配方，可用于治疗与凋亡相关的疾病，包括神经退行性疾病、多谷氨酸链相关疾病、癫痫、缺血、不育症、心血管疾病、肾脏缺氧、肝炎和艾滋病等。其中，哌嗪化合物由公式（I）表示，其中R0，R1，R2，R3，k，l，m，n和X的定义如下：
• 9-(piperazinylalkyl) carbazoles as bax-modulators
  申请人：Merck Serono SA

  公开号：US08053436B1

  公开（公告）日：2011-11-08

  The present invention is related to piperazine derivatives of carbazole of formula (I) notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such piperazine derivatives of carbazole. Said piperazine derivatives of carbazole are efficient modulators, in particular efficient inhibitors, of the Bax function and/or activation. The present invention is furthermore related to novel piperazine derivatives of carbazole as well as methods of their preparation.

  本发明涉及公式(I)的咪唑衍生物的咔唑，特别是用作药物活性化合物的咪唑衍生物的咔唑，以及含有这种咪唑衍生物的咔唑的制药配方。所述的咪唑衍生物的咔唑是高效的调节因子，特别是高效的抑制剂，可用于Bax功能和/或激活。本发明还涉及新型咪唑衍生物的咔唑以及其制备方法。
• 9-(piperazinylalkyl) carbazoles as Bax-modulators
  申请人：Halazy Serge

  公开号：US08410110B2

  公开（公告）日：2013-04-02

  Piperazine compounds for use as pharmaceutically active compounds and in pharmaceutical formulations that are useful for the treatment of disorders associated with apoptosis, including neurodegenerative disorders, diseases associated with polyglutamine tracts, epilepsy, ischemia, infertility, cardiovascular disorders, renal hypoxia, hepatitis and AIDS, where the piperazine compounds are represented by formula (I) and the terms R0, R1, R2, R3, k, l, m, n, and X are defined herein:

  Piperazine化合物可用作药物活性化合物和制药配方，对于与凋亡有关的疾病的治疗有用，包括神经退行性疾病、与多谷氨酸氨基酸序列相关的疾病、癫痫、缺血、不孕症、心血管疾病、肾脏缺氧、肝炎和艾滋病，其中Piperazine化合物由公式（I）表示，术语R0、R1、R2、R3、k、l、m、n和X在此定义：
• Polymer, rubber composition and tire using the same
  申请人：Sumitomo Rubber Industries, Ltd.

  公开号：EP2177562A2

  公开（公告）日：2010-04-21

  The present invention has its object to provide: a rubber composition which includes a novel polymer having a specific nitrogen-containing compound and has an excellent balance between fuel economy and wet grip performance; and a tire produced using the rubber composition, which has the above properties. The present invention relates to a polymer obtainable by copolymerizing a conjugated diene compound and/or an aromatic vinyl compound with a nitrogen-containing compound having a specific structure.

  本发明的目的是提供：一种橡胶组合物，其中包括一种具有特定含氮化合物的新型聚合物，并在燃油经济性和湿地抓地性能之间取得极佳的平衡；以及一种使用该橡胶组合物生产的轮胎，该轮胎具有上述性能。 本发明涉及一种可通过共聚二烯化合物和/或芳香乙烯基化合物与具有特定结构的含氮化合物共聚而获得的聚合物。