1-苄基氨基胍 | 46121-22-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-苄基氨基胍
• 英文名称: benzylamino-guanidine
• 英文别名: Benzylamino-guanidin；1-benzylaminoguanidine；1-Benzylaminoguanidin；Benzylaminoguanidine；Guanidine, benzylamino-；2-(benzylamino)guanidine
• CAS: 46121-22-6
• 化学式: C₈H₁₂N₄
• 分子量: 164.21
• InChiKey: UFJCEIJCOUJELZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  76.4
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  1-苄基氨基胍 在 盐酸 、 sodium nitrite 作用下， 以 水 为溶剂， 生成 1-(benzyloxy)-2,4-dinitrobenzene
  参考文献：
  名称：

  Synthesis and Reactions of 1-Nitroso-1-alkyl-2-guanyl-and -2-carbamylhydrazines

  摘要：

  DOI：

  10.1021/jo01013a066
• 作为产物：
  描述：

  2-benzylidenehydrazinecarboximidamide 在 溶剂黄146 、 铂 作用下， 生成 1-苄基氨基胍
  参考文献：
  名称：

  1-(Alkylamino)-guanidines

  摘要：

  DOI：

  10.1021/ja01132a007

文献信息

• Base-substituted benzylamine analogs for use as coagulation factor xa inhibitors, the production and use thereof
  申请人：Stürzebecher Jörg

  公开号：US20070066539A1

  公开（公告）日：2007-03-22

  The invention relates to the novel base-substituted benzylamine analogs of general formula (I), wherein A represents P 2 -P 1 with P 1 =(A) and P 2 =(B), for use as coagulation factor Xa inhibitors. The invention also relates to the production and use of said analogs in the therapy and prophylaxis of cardiovascular diseases and thromboembolic events.

  该发明涉及一般式（I）的新型基取代苄胺类似物，其中A代表P2-P1，P1=(A)和P2=(B)，用作凝血因子Xa抑制剂。该发明还涉及所述类似物的制备和在心血管疾病和血栓栓塞事件的治疗和预防中的应用。
• TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE
  申请人：Steinmetzer Torsten

  公开号：US20100022781A1

  公开（公告）日：2010-01-28

  The invention relates to inhibitors of trypsin-like serine proteases of the general formula (I) which, as well as plasmin, also inhibit plasma kallikrien, and to their preparation and use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.

  该发明涉及一般式（I）的胰蛋白酶样丝氨酸蛋白酶抑制剂，除了抑制纤溶酶外，还抑制血浆激肽原，以及它们的制备和用作药物，优选用于治疗失血，特别是在高纤溶状态、器官移植或心脏手术干预，特别是心肺转流手术中，或作为纤维蛋白粘合剂的组分。
• Inhibitors of the blood-clotting factor xa, production thereof and use of the same
  申请人：Sturzebecher Jorg

  公开号：US20050119190A1

  公开（公告）日：2005-06-02

  The invention relates to novel inhibitors of clotting factor Xa, the preparation and use thereof for therapy, prophylaxis and diagnosis of cardiovascular disorders and thromboembolic events.

  本发明涉及一种新型凝血因子Xa抑制剂，其制备和用途用于治疗、预防和诊断心血管疾病和血栓栓塞事件。
• Acylated 4-amidino-and-4-guanidinobenzylamines for inhibition of plasma kallikrein
  申请人：Sturzebecher Jorg

  公开号：US20060148901A1

  公开（公告）日：2006-07-06

  The invention relates to the use of acylated 4-amidino- or 4-guanidinobenzylamine in accordance with the general formula I P4-P3-P2-P1  (I), where P4 is a monosubstituted or polysubstituted or unsubstituted benzylsulfonyl group, P3 is a monosubstituted or polysubstituted or unsubstituted, natural or unnatural α-amino acid or α-imino acid in the D configuration, P2 is a monosubstituted or polysubstituted or unsubstituted, natural or unnatural α-amino acid or α-imino acid in the L configuration, and P1 is a monosubstituted or polysubstituted or unsubstituted 4-amidino- or 4-guanidinobenzylamine group, for inhibiting plasma kallikrein (PK), factor XIa and factor XIIa, in particular for preventing the activation of coagulation at synthetic surfaces and for systemic administration as anticoagulants/-antithrombotic agents, in particular for preventing the activation of coagulation at synthetic surfaces for the purpose of averting thromboembolic events.

  本发明涉及使用通式IP4-P3-P2-P1的酰化4-氨基酰胺或4-鸟氨酰胺苯甲胺，其中，P4是单取代、多取代或未取代的苯甲磺酰基，P3是单取代、多取代或未取代的天然或非天然的D构型α-氨基酸或α-亚氨酸，P2是单取代、多取代或未取代的天然或非天然的L构型α-氨基酸或α-亚氨酸，P1是单取代、多取代或未取代的4-氨基酰胺或4-鸟氨酰胺苯甲胺基团，用于抑制血浆激酶（PK）、XIa因子和XIIa因子，特别是用于在合成表面上预防凝血的激活和全身给药作为抗凝血剂/-抗血栓剂，特别是用于预防在合成表面上凝血的激活以避免血栓栓塞事件的发生。
• Urokinase inhibitors, production and use thereof
  申请人：Sturzebecher Jorg

  公开号：US20050176993A1

  公开（公告）日：2005-08-11

  The invention relates to novel inhibitors of urokinase and to their preparation and use for the therapy, prophylaxis and diagnosis of a tumor, in particular for reducing the formation of tumor metastases.

  该发明涉及一种新型尿激酶抑制剂及其制备和用于治疗、预防和诊断肿瘤的用途，特别是用于减少肿瘤转移的形成。