11-羟基苯并[a]芘 | 56892-32-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 中文名称: 11-羟基苯并[a]芘
• 英文名称: benzo[a]pyrenol-(11)
• 英文别名: 11-Hydroxy-benzo[a]pyren；11-Hydroxy-benzo[def]chrysen；11-Hydroxybenzo[a]pyrene；benzo[a]pyren-11-ol
• CAS: 56892-32-1
• 化学式: C₂₀H₁₂O
• 分子量: 268.315
• InChiKey: JATVWVYVLWEYNL-UHFFFAOYSA-N

物化性质

• 熔点：
  220°C (rough estimate)
• 沸点：
  371.47°C (rough estimate)
• 密度：
  1.0921 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

制备方法与用途

类别：有毒物品

可燃性危险特性：

• 可燃
• 燃烧时产生刺激烟雾

储运特性：

• 通风
• 低温干燥

灭火剂：

• 干粉
• 泡沫
• 沙土
• 二氧化碳
• 雾状水

反应信息

• 作为反应物：
  描述：

  11-羟基苯并[a]芘 、 碘甲烷 以0%的产率得到
  参考文献：
  名称：

  Ariese F., Kok S. J., Verkaik M., Hoornweg G. Ph., Gooijer C., Velthorst +, Anal. Chem., 65 (1993) N 8, S 1100-1106

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氟酸 作用下， 生成 11-羟基苯并[a]芘
  参考文献：
  名称：

  Synthesis of 2-Hydroxy-3,4-benzpyrene and 2-Methyl-3,4-benzpyrene

  摘要：

  DOI：

  10.1021/ja01854a010

文献信息

• METHOD OF DETECTING ESTROGEN-LIKE SUBSTANCE BY USING PLANT
  申请人：National University Corporation Hokkaido University

  公开号：EP1790216A1

  公开（公告）日：2007-05-30

  The present invention provides a detection method of estrogen-like chemicals, which uses a plant, needs not use a complicated procedure as sterilization and is highly sensitive as a sensor. The present invention is a transformed plant, which is transformed by transducing effector 1 sequence, effector 2 sequence, a target DNA and a reporter gene, wherein said effector 1 sequence has a promoter, a nuclear localization signal, and a chimeric gene comprising a domain coding a polypeptide binding to a target DNA and a domain coding a ligand binding polypeptide of intranuclear receptors for estrogen-like chemicals, said effector 2 sequence has a promoter, a nuclear localization signal, and a chimeric gene comprising a domain coding an interacting domain with intranuclear receptors in a transcriptional coactivator and a domain coding a transcriptional activation domain, and said reporter gene locates in the down stream of said target DNA. The transformed plant is contacted with estrogen-like chemicals and the expression of the reporter gene in the plant is detected.

  本发明提供了一种雌激素类化学物质的检测方法，该方法使用植物，无需复杂的消毒程序，作为传感器灵敏度高。 本发明是一种转化植物，它是通过转入效应子 1 序列、效应子 2 序列、靶 DNA 和报告基因而转化的，其中所述效应子 1 序列具有启动子、核定位信号和嵌合基因，嵌合基因包括编码与靶 DNA 结合的多肽的结构域和编码雌激素类化学物质核内受体配体结合多肽的结构域、所述效应物 2 序列具有启动子、核定位信号和嵌合基因，嵌合基因包括编码与转录辅激活剂核内受体相互作用结构域的结构域和编码转录激活结构域的结构域，所述报告基因位于所述靶 DNA 的下游。将转化植物与雌激素类化学物质接触，检测植物中报告基因的表达情况。
• YAGI H.; HOLDER G. M.; DANSETTE P. M.; HERNANDEZ O.; YEH H. J. C.; LEMAHI+, J. ORG. CHEM. <JOCE-AH>, 1976, 41, NO 6, 977-985
  作者：YAGI H.、 HOLDER G. M.、 DANSETTE P. M.、 HERNANDEZ O.、 YEH H. J. C.、 LEMAHI+

  DOI：——

  日期：——
• Method for Detecting Estrogen-Like Chemicals by Plant
  申请人：Yamazaki Kenichi

  公开号：US20080199858A1

  公开（公告）日：2008-08-21

  The present invention provides a detection method of estrogen-like chemicals, which uses a plant, needs not use a complicated procedure as sterilization and is highly sensitive as a sensor. The present invention is a transformed plant, which is transformed by transducing effector 1 sequence, effector 2 sequence, a target DNA and a reporter gene, wherein said effector 1 sequence has a promoter, a nuclear localization signal, and a chimeric gene comprising a domain coding a polypeptide binding to a target DNA and a domain coding a ligand binding polypeptide of intranuclear receptors for estrogen-like chemicals, said effector 2 sequence has a promoter, a nuclear localization signal, and a chimeric gene comprising a domain coding an interacting domain with intranuclear receptors in a transcriptional coactivator and a domain coding a transcriptional activation domain, and said reporter gene locates in the down stream of said target DNA. The transformed plant is contacted with estrogen-like chemicals and the expression of the reporter gene in the plant is detected.
• Multi-stage stem cell carcinogenesis
  申请人：Krtolica Ana

  公开号：US20100162416A1

  公开（公告）日：2010-06-24

  The present invention relates to a system of multi-stage stem cell carcinogenesis and a method of generating such multi-stage stem cell carcinogenesis system. Various stages of cancer stem cells can be generated from normal stem cells via mutagenesis. The system of the present invention enables monitoring changes in the ability of cells to transition from one stage of carcinogenesis to another and to identify genetic pathways and molecules that influence carcinogenesis. The present invention also enables a high-throughput and nonbiased screening for targets that preferentially affect cancer stem cells relative to non-cancer stem cells or their derivatives during stem cell carcinogenesis, thus is useful in developing anti-cancer therapeutics.