氯乙醇磷酸酯 | 115-96-8

• 物质功能分类: 有机原料 - 无机酸酯
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: 氯乙醇磷酸酯
• 中文别名: 三(2-氯乙基)磷酸酯；磷酸三(β-氯乙酯)；三(β-氯乙基)磷酸酯；三氯乙基磷酸酯阻燃增塑剂；磷酸三(2-氯乙基)酯；磷酸三氯乙酯；TCEP；2-氯乙基磷酸双(2-氯乙基)酯
• 英文名称: Tris(2-chloroethyl) phosphate
• 英文别名: TCEP；tris(chloroethyl) phosphate
• CAS: 115-96-8；29716-44-7
• 化学式: C₆H₁₂Cl₃O₄P
• mdl: MFCD00000967
• 分子量: 285.492
• InChiKey: HQUQLFOMPYWACS-UHFFFAOYSA-N

物化性质

• 熔点：
  -51 °C
• 沸点：
  192 °C/10 mmHg (lit.)
• 密度：
  1.39 g/mL at 25 °C (lit.)
• 闪点：
  450 °F
• 溶解度：
  H2O：可溶7.82g/L
• LogP：
  1.7 at 20℃
• 物理描述：
  Tris(2-chloroethyl) phosphate is an odorless clear liquid. Neutral pH. (NTP, 1992)
• 颜色/状态：
  Clear, transparent liquid
• 气味：
  Low odor
• 蒸汽密度：
  Relative vapor density (air = 1): 9.8
• 蒸汽压力：
  6.13X10-2 mm Hg at 25 °C
• 稳定性/保质期：

  Stable under recommended storage conditions.

• 自燃温度：
  480 °C
• 分解：
  Rapid decomposition occurs above 220 °C.
• 粘度：
  45 cP at 20 °C
• 折光率：
  Index of refraction: 1.4721 at 20 °C/D
• 保留指数：
  1740;1740;1740;1747.2;295.96

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

代谢

三(2-氯乙基)磷酸酯(TCEP)与人类肝脏S9部分和微粒体一起孵化。TCEP被代谢成它的二酯和一个氧化脱卤素产物的情况很差。

... Tris(2-chloroethyl) phosphate (TCEP) ... /was/ incubated with human liver S9 fraction and microsomes. ... TCEP was poorly metabolized into its diester and a product of oxidative dehalogenation. ...

来源:Hazardous Substances Data Bank (HSDB)

代谢

三(2-氯乙基)磷酸盐(TRCP),一种阻燃剂,在亚慢性口服给药后,会在大脑的海马区产生剂量、性别和种属依赖性的损伤。这种损伤在雌性F344大鼠中比雄性F344大鼠更常见且更严重,而在B6C3F1小鼠中并未观察到。本次调查旨在检测TRCP的代谢是否存在性别和种属差异,以解释毒性差异。TRCP衍生放射性的消除在 mice 中更快,其在8小时内通过尿液排出了大于70%的175 mg/kg口服剂量,而雄性或雌性大鼠的排出量则约为40%。然而,尿液中TRCP衍生放射性的代谢轮廓在两种动物中相似。雌性大鼠尿液中的主要代谢物被鉴定为双(2-氯乙基)羧甲基磷酸。这种代谢物与在雄性大鼠和小鼠尿液中发现的主要代谢物共同层析。在雌性大鼠尿液中还发现了另外两种代谢物,分别为双(2-氯乙基)氢磷酸和双(2-氯乙基)2-羟乙基磷酸的葡萄糖苷酸。这些代谢物也与在雄性大鼠和小鼠尿液中发现的代谢物共同层析。在大鼠中,TRCP的代谢并未被连续九天每天175 mg/kg剂量的处理所诱导或抑制。毒性,如癫痫发作所证明的,在预先用乙醛脱氢酶抑制剂处理的雄性大鼠中被增强。

Tris(2-chloroethyl) phosphate (TRCP), a flame retardant, produces a dose-, sex-, and species-dependent lesion in the hippocampal region of the brain following subchronic oral administration. This lesion is more common and more severe in female F344 rats than in male F344 rats, and is not observed in B6C3F1 mice. The present investigation of the metabolism of TRCP was designed to detect sex and species variations that might account for differences in toxicity. Elimination of TRCP-derived radioactivity was more rapid in mice, which excreted greater than 70% of an oral dose of 175 mg/kg in urine in 8 hr vs approximately 40% for male or female rats. However, the metabolic profile of TRCP-derived radioactivity in urine was similar for both species. The major metabolite in female rat urine was identified as bis(2-chloroethyl) carboxymethyl phosphate. This metabolite co-chromatographed with the major metabolite found in both male rat and mouse urine. Two additional metabolites identified in female rat urine were bis(2-chloroethyl) hydrogen phosphate and the glucuronide of bis(2-chloroethyl) 2-hydroxyethyl phosphate. These metabolites also cochromatographed with metabolites found in male rat and mouse urine. TRCP metabolism in rats was not induced or inhibited by nine daily 175 mg/kg doses. Toxicity, as evidenced by seizures, was potentiated in male rats pretreated with inhibitors of aldehyde dehydrogenase.

来源:Hazardous Substances Data Bank (HSDB)

代谢

来自雄性大鼠的肝微粒体部分可以代谢TCEP，而雌性大鼠的则不能。然而，无论性别如何，肝脏切片和血液血浆都能代谢该化合物，这表明至少部分代谢是在微粒体之外的。来自男性和女性的肝脏切片和微粒体都能代谢TCEP，但血浆和全血则不能。

The hepatic microsomal fraction from male rats, but not female rats, metabolized TCEP. Liver slices and blood plasma, however, of both sexes metabolized the compound, demonstrating that at least part of the metabolism is extramicrosomal. Liver slices and microsomes from both male and female humans metabolized TCEP, but plasma and whole blood did not.

来源:Hazardous Substances Data Bank (HSDB)

代谢

在一项对B6C3F1雄性小鼠的研究中，超过70%的175毫克/千克体重的口服剂量的(14)C标记的TCEP在8小时内通过尿液排出。在小鼠尿液中发现的TCEP代谢物包括双(2-氯乙基)羧甲基磷酸盐、双(2-氯乙基)氢磷酸盐和双(2-氯乙基)2-羟乙基磷酸葡萄糖苷酸。

In a study on male B6C3F1 mice, more than 70% of an oral dose of 175 mg (14)C-labelled TCEP/kg body weight was excreted in urine within 8 hr. Identified urinary metabolites of TCEP in mice were bis(2-chloroethyl) carboxymethyl phosphate, bis(2-chloroethyl) hydrogen phosphate and bis(2-chloroethyl) 2-hydroxyethyl phosphate glucuronide.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 毒性总结

识别和使用：三（2-氯乙基）磷酸是一种清澈透明的液体。它主要用于作为聚酯、聚氯乙烯和其他聚合物的阻燃性增塑剂和粘度调节剂。人类暴露和毒性：三（2-氯乙基）磷酸在有无代谢激活的情况下，未能一致地显示出可检测的未计划DNA合成，并且未能在人类WI-38细胞中显示出剂量-反应关系。动物研究：在重复剂量研究中，三（2-氯乙基）磷酸对大脑（大鼠海马损伤）、肝脏和肾脏产生了不良影响。对眼睛无刺激性，但在文献中关于对皮肤的刺激性有相互矛盾的报道，尚未进行过敏性测试。不是致畸形的。它对大鼠和雄性小鼠的生育能力有不利影响。体外致突变性测试结果不一致，体内微核试验结果模棱两可。三（2-氯乙基）磷酸在大鼠和小鼠的各个器官位点引起了良性肿瘤和恶性肿瘤。一个非常高的口服剂量导致了一些血浆胆碱酯酶和脑神经病靶酯酶的抑制，但并未引起迟发性神经毒性。在大鼠中，高剂量引起了抽搐、大脑损伤和性能下降。在大鼠和小鼠中的代谢物包括双（2-氯乙基）羧甲基磷酸；双（2-氯乙基）氢磷酸；和双（2-氯乙基）-2-羟基乙基磷酸葡萄糖苷酸，主要通过尿液排出。

IDENTIFICATION AND USE: (Tris(2-chloroethyl) phosphate is a Clear, transparent liquid. It is used primarily as an additive plasticizer and viscosity regulator with flame-retarding properties for polyurethane, polyesters, polyvinyl chloride and other polymers. HUMAN EXPOSURE AND TOXICITY: Tris(2-chloroethyl) phosphate did not consistently demonstrate detectable unscheduled DNA synthesis with and without metabolic activation and failed to show a dose-response relationship in human WI-38 cells. ANIMAL STUDIES: In repeat dose studies Tris(2-chloroethyl) phosphate caused adverse effects on the brain (hippocampal lesions in rats), liver and kidneys. Non-irritant to eyes, but conflicting reports in the literature on skin irritation, has not been tested for sensitization potential. Not teratogenic. It adversely affects the fertility of male rats and mice. In vitro mutagenicity test results were inconsistent and an in vivo micronucleus test gave equivocal results. Tris(2-chloroethyl) phosphate causes benign and malignant tumors at various organ sites in rats and mice. A very high oral dose caused some inhibition of plasma cholinesterase and brain neuropathy target esterase, but did not cause delayed neurotoxicity. In rats, a high dose caused convulsions, brain lesions and impaired performance. Metabolites in rats and mice include bis(2-chloroethyl)carboxymethyl phosphate; bis(2-chloroethyl) hydrogen phosphate; and bis(2-chloroethyl)-2-hydroxyethyl phosphate glucuronide excreted mainly via the urine.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

评估：关于三(2-氯乙基)磷酸盐的致癌性，没有可用的流行病学数据。在实验动物中，关于三(2-氯乙基)磷酸盐的致癌性只有有限证据。总体评估：三(2-氯乙基)磷酸盐的致癌性对人不可分类（第3组）。

Evaluation: No epidemiological data relevant to the carcinogenicity of tris(2-chloroethyl)phosphate were available. There is limited evidence for the carcinogenicity of tris(2-chloroethyl)phosphate in experimental animals. Overall evaluation: Tris(2-chloroethyl)phosphate is not classifiable as to its carcinogenicity to humans (Group 3).

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌物分类

国际癌症研究机构致癌物：三（2-氯乙基）磷酸盐

IARC Carcinogenic Agent:Tris(2-chloroethyl) phosphate

来源:International Agency for Research on Cancer (IARC)

毒理性

• 致癌物分类

国际癌症研究机构（IARC）致癌物分类：第3组：无法归类其对人类致癌性

IARC Carcinogenic Classes:Group 3: Not classifiable as to its carcinogenicity to humans

来源:International Agency for Research on Cancer (IARC)

毒理性

• 致癌物分类

国际癌症研究机构专著：第48卷：（1990年）一些阻燃剂和纺织化学品以及在纺织制造工业中的暴露

IARC Monographs:Volume 48: (1990) Some Flame Retardants and Textile Chemicals, and Exposures in the Textile Manufacturing Industry

来源:International Agency for Research on Cancer (IARC)

吸收、分配和排泄

三(2-氯乙基)磷酸盐(TRCP)是一种广泛用于工业应用的阻燃剂。在亚慢性研究中，据报道给大鼠和小鼠口服TRCP会在海马脑区产生剂量、性别和种属依赖性的病变。目前的调查已经检查了TRCP在雄性和雌性大鼠中的代谢、消除和区域脑分布。(14)C TRCP通过灌胃给药(0、175、350或700 mg/kg)，并收集尿液、粪便、呼出的挥发性物质、CO2和选定的组织。在给雄性和雌性大鼠单次TRCP剂量后2小时，以及给雌性大鼠单次剂量和14次每日剂量的最后一次后24小时，确定了(14)C的区域脑分布。这些研究的结果表明，TRCP很容易从胃肠道吸收，分布到所有脑区，并且在72小时内代谢和排泄几乎完成。大部分TRCP衍生的放射性活性通过尿液排出(高达85%)，粪便、挥发性物质和 的总和仅占剂量的不到10%。与TRCP给药(350和700 mg/kg)相关的主要毒性表现是在治疗后的2小时内发生癫痫发作，此时脑组织中存在的TRCP衍生的放射性活性大部分是母体化合物形式。在稍后时间检测到无法提取的(14)C的痕迹，但这种物质在脑部相对于其他组织的浓度并不高。...

Tris(2-chloroethyl) phosphate (TRCP) is a flame retardant that has a wide variety of industrial applications. In subchronic studies, oral administration of TRCP to rats and mice has been reported to produce dose-, sex-, and species-dependent lesions in the hippocampal brain region. The present investigation has examined the metabolism, elimination, and regional brain distribution of (14)C TRCP in male and female rats. (14)C TRCP was administered by gavage (0, 175, 350, or 700 mg/kg) and urine, feces, exhaled volatiles, CO2, and selected tissues were collected. Regional brain distribution of (14)C was determined 2 hr following single doses of TRCP to male and female rats, and 24 hr after a single dose and the last of 14 daily doses of TRCP to female rats. Results of these studies indicate that TRCP is readily absorbed from the gastrointestinal tract, distributed to all brain regions, and that metabolism and excretion are nearly complete in 72 hr. Most of the TRCP-derived radioactivity was excreted in urine (up to 85%), with feces, volatiles, and CO2 combined accounting for less than 10% of the dose. Predominant signs of toxicity associated with TRCP administration (350 and 700 mg/kg) were seizures within 2 hr of treatment, when most of the TRCP-derived radioactivity present in brain tissue was in the form of the parent compound. Traces of inextractable (14)C were detected at later times, but this material was not concentrated in brain relative to other tissues. ...

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

TRCP衍生的放射性物质在小鼠体内的消除速度更快，小鼠在8小时内通过尿液排出了超过70%的175毫克/千克口服剂量，而大鼠（无论雄性还是雌性）的排出量大约为40%。

... Elimination of TRCP-derived radioactivity was more rapid in mice, which excreted greater than 70% of an oral dose of 175 mg/kg in urine in 8 hr vs approximately 40% for male or female rats. ...

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

物质似乎没有通过皮肤被吸收。

Material does not appear to be absorbed through the skin.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

(14)C标记的TCEP在给予50微摩尔/千克体重的5周龄雄性Wistar大鼠口服后的分布和排泄。给药后最初6小时内，标签被各种组织特别是肝脏和肾脏浓缩，然后迅速减少。大部分标签在24小时内被排泄，到168小时时，组织中剩余的不到1%。尿液中占96%，粪便中占6%，呼出气体中占2%。

The distribution and excretion of (14)C-labelled TCEP in 5-week-old male Wistar rats orally dosed with 50 umol/kg body weight. The label was concentrated by various tissues, especially the liver and kidney, during the first 6 hr following administration and then rapidly decreased. Most of the label was excreted by 24 hr and by 168 hr less than 1% remained in tissues. Urine accounted for 96%, feces for 6%, and expired air for 2% of the label.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  9
• 危险品标志：
  Xn
• 安全说明：
  S36/37,S61
• 危险类别码：
  R22,R51/53,R40
• WGK Germany：
  3
• 海关编码：
  2919900090
• 危险品运输编号：
  UN 2810 6.1/PG 3
• RTECS号：
  KK2450000
• 包装等级：
  Z01

制备方法与用途

特点

磷酸三(2-氯乙基)酯（TCEP）是一种典型的有机磷系阻燃剂。它是一种微带奶油味的浅黄色油状液体，微溶于水。在聚合物中添加TCEP后，除了具有自熄性能外，还兼有防潮、防紫外线和抗静电等特点，并广泛用于纤维素、环氧树脂、酚醛树脂等材料以及纺织品、PVC材料和玩具等生活用品当中。

合成方法

向系统中加入165 mL电解质、1.5 M氯化氢在乙烯氯丙烷中的溶液，以及0.5 M水。随后加入3.6 g称量过的红磷样品，并打开循环泵和冷却水。通入3 A的电流后，逐渐添加氯化氢和水在乙烯氯丙烷中的混合物，以确保电解过程中电解液中氯化氢和水分保持恒定浓度。电解完成后，过滤电解溶液去除磷。对获得的残留物进行称重，并根据差值确定溶解磷的重量。

接下来，在30至100°C和10-15毫米汞柱的压力下，通过喷水泵从滤液中用HCl和H2O蒸馏2.6 g乙烯氯丙烷，以获取被外加剂污染的原油残留物。随后在分液漏斗中使用20 mL 10% NaOH溶液洗涤，去除酸性添加剂；用水洗涤三次（每次30 mL），直至pH值中性，从而净化产品。最后，在真空条件下逐步升温至160°C和1.5 mmHg的条件下分离水残留物及挥发性外加剂，以获得磷酸三(2-氯乙基)酯。

化学性质

TCEP为浅黄色油状液体，微带奶油味。它能与乙醇、丙酮、氯仿、四氯化碳等有机溶剂相溶，稍溶于水。

用途

TCEP广泛用于聚氨酯泡沫阻燃以及聚氯乙烯阻燃增塑等。作为一种高效的阻燃剂，TCEP可以作为化纤织物和醋酸纤维素的添加剂，除自熄性外，还改善了耐水性和抗静电性，一般用量为5～10份。

此外，磷酸三(2-氯乙基)酯（TCEP）广泛用于醋酸纤维素、硝基纤维素、乙基纤维素、聚氯乙烯、聚氨酯、聚醋酸乙烯和酚醛树脂中。作为阻燃性增塑剂时，它还可用作金属萃取剂、润滑油和汽油添加剂，以及聚酰亚胺加工改性剂。大鼠口毒性LD50为1410 mg/kg。

生产方法

TCEP的制备通常采用两种方法：一种是三氯氧磷与环氧乙烷在偏钒酸钠催化剂下于50℃反应，再经中和、水洗、真空脱水及脱低沸物处理；另一种是以氯乙醇为原料，与三氯氧磷或三氯化磷反应制造磷酸三(2-氯乙基)酯。

具体步骤如下：将326 kg三氯氧磷和1.0 kg偏钒酸钠投入反应釜中。充氮驱除空气后，在真空条件下通入650 kg环氧乙烷，于45～50°C下搅拌2～3小时。随后蒸出过量的环氧乙烷并加碱中和至中性，水洗，真空脱水得成品。

类别

TCEP属于有毒物质，毒性分级为中毒。急性毒性表现为：口服-大鼠 LD50: 1230 毫克/公斤；口服-小鼠 LD50: 1866 毫克/公斤。刺激数据包括皮肤轻微反应（兔，10毫克/24小时）和眼睛轻度刺激（兔，500毫克/24小时）。该物质可燃，在火场分解产生有毒氯化氢和磷氧化物气体。

储运特性

储存于低温、通风及干燥的库房中。

灭火剂

使用水、二氧化碳、泡沫或砂土灭火。

反应信息

• 作为反应物：
  描述：

  氯乙醇磷酸酯 生成 1,2-二氯乙烷
  参考文献：
  名称：

  Korschak et al., Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1958, p. 210,215; engl. Ausg. S. 196, 200

  摘要：

  DOI：
• 作为产物：
  描述：

  环氧乙烷 在 三氯氧磷 作用下， 反应 2.0h， 以99.2%的产率得到氯乙醇磷酸酯
  参考文献：
  名称：

  负载路易斯酸性离子液体催化的环氧醚裂解反应

  摘要：

  用路易斯酸性离子液体催化环氧丙烷与POCl 3的反应。考虑到较低的成本和催化活性，我们得出结论，从经济角度来看，[Et 3 NH] Cl / AlCl 3是最具吸引力的离子液体。但是由于对水和空气敏感，很容易使其失活。而且，由于反应中的回收困难，它不能容易地重复使用。然而，负载[Et 3 NH] Cl / AlCl 3催化剂可以解决上述问题。负载[Et 3 NH] Cl / AlCl 3催化剂可以很容易地通过过滤器分离，并可以以98％的产率重复使用5次。此外，该催化剂可用于其他环氧醚裂解反应。

  DOI：

  10.1016/j.cclet.2012.09.015
• 作为试剂：
  描述：

  苯 在 三氯化铝 、 氯乙醇磷酸酯 、 三氯化磷 作用下， 生成 苯基二氯化磷
  参考文献：
  名称：

  Kormachev, V. V.; Solodova, K. V.; Vorozheva, T. N., Journal of general chemistry of the USSR, 1984, vol. 54, p. 895 - 898

  摘要：

  DOI：

文献信息

• [EN] HYDROSILYLATION REACTION CURABLE COMPOSITIONS AND METHODS FOR THEIR PREPARATION AND USE<br/>[FR] COMPOSITIONS DURCISSABLES PAR UNE RÉACTION D'HYDROSILYLATION ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
  申请人：DOW CORNING

  公开号：WO2013000788A1

  公开（公告）日：2013-01-03

  A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a platinum-ligand complex that can be prepared by reacting a platinum precursor and a ligand.

  一种组合物包含（A）氢硅烷化反应催化剂和（B）一种脂肪族不饱和化合物，每分子平均含有一个或多个能够进行氢硅烷化反应的脂肪族不饱和有机基团。该组合物能够通过氢硅烷化反应反应形成反应产物，如硅烷、树胶、凝胶、橡胶或树脂。成分（A）包含一种铂配体络合物，可通过反应铂前体和配体制备。
• [EN] ACRYLATE-FUNCTIONAL BRANCHED ORGANOSILICON COMPOUND, METHOD OF PREPARING SAME, AND COPOLYMER FORMED THEREWITH<br/>[FR] COMPOSÉ D'ORGANOSILICIUM RAMIFIÉ À FONCTION ACRYLATE, SON PROCÉDÉ DE PRÉPARATION ET COPOLYMÈRE FORMÉ AVEC CELUI-CI
  申请人：DOW SILICONES CORP

  公开号：WO2020142474A1

  公开（公告）日：2020-07-09

  A method of preparing an acrylate-functional branched organosilicon compound ("compound") is provided, and comprises reacting (A) a branched organosilicon compound and (B) an acrylate compound in the presence of (C) a catalyst, wherein component (A) has the general formula X-Si(R1)3, where X comprises a halogen-functional moiety and each R1 is selected from R and –OSi(R4)3, with the proviso that at least one R1 is –OSi(R4)3; each R4 is selected from R, –OSi(R5)3, and –[OSiR2]mOSiR3; each R5 is selected from R, –OSi(R6)3, and –[OSiR2]mOSiR3; each R6 is selected from R and –[OSiR2]mOSiR3; each R is an independently selected hydrocarbyl group; and 0≤m≤100; with the proviso that at least one of R4, R5 and R6 is –[OSiR2]mOSiR3. The compound prepared by the method, a copolymer comprising the reaction product of the compound and a second compound, a method of forming the copolymer, and a composition comprising the copolymer are each also provided.

  提供了一种制备丙烯酸酯官能化分支有机硅化合物（“化合物”）的方法，包括在催化剂存在下，使（A）分支有机硅化合物和（B）丙烯酸酯化合物发生反应，其中组分（A）具有一般式X-Si（R1）3，其中X包括卤素官能基，每个R1从R和–OSi（R4）3中选择，但至少一个R1为–OSi（R4）3；每个R4从R、–OSi（R5）3和–[OSiR2]mOSiR3中选择；每个R5从R、–OSi（R6）3和–[OSiR2]mOSiR3中选择；每个R6从R和–[OSiR2]mOSiR3中选择；每个R是独立选择的烃基；且0≤m≤100；但至少一个R4、R5和R6为–[OSiR2]mOSiR3。还提供了通过该方法制备的化合物，包括化合物和第二化合物的反应产物的共聚物，形成共聚物的方法，以及包含共聚物的组合物。
• NITROGEN-CONTAINING COMPOUNDS SUITABLE FOR USE IN THE PRODUCTION OF POLYURETHANES
  申请人：Evonik Degussa GmbH

  公开号：US20180194889A1

  公开（公告）日：2018-07-12

  The present invention provides for the use of nitrogen compounds of formula (I) and/or of corresponding quaternized and/or protonated compounds for production of polyurethanes, compositions containing these compounds and polyurethane systems, especially polyurethane foams, which have been obtained using the compounds.

  本发明提供了使用式(I)的氮化合物和/或相应的季铵化和/或质子化化合物用于生产聚氨酯、含有这些化合物的组合物和聚氨酯体系的方法，特别是使用这些化合物获得的聚氨酯泡沫。
• Hydrosilylation Reaction Catalysts and Curable Compositions and Methods for Their Preparation and Use
  申请人：Dow Corning Corporation

  公开号：US20140296468A1

  公开（公告）日：2014-10-02

  A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains an iron-organosilicon ligand complex that can be prepared by reacting an iron carbonyl compound and an organosilicon ligand.

  一种组合物包含（A）一个氢硅烷基化反应催化剂和（B）一种脂肪族不饱和化合物，每个分子平均含有一个或多个能够进行氢硅烷基化反应的脂肪族不饱和有机基团。该组合物能够通过氢硅烷基化反应反应形成反应产物，如硅烷、树脂、凝胶、橡胶或树脂。成分（A）包含一种铁-有机硅配体络合物，可通过反应铁羰基化合物和有机硅配体制备。
• AMIDINE GROUP - OR GUANIDINE GROUP - CONTAINING SILANE
  申请人：SIKA TECHNOLOGY AG

  公开号：US20170081348A1

  公开（公告）日：2017-03-23

  A silane of the formula (I) containing at least one aliphatic amidine group- or guanidine group-containing alkoxy group, to a method for producing same, to conversion products thereof, and to the use thereof as a catalyst in curable compositions, in particular based on silane group-containing polymers. The silane of the formula (I) is largely odorless and non-volatile at room temperature. The silane accelerates the hydrolysis and condensation reaction of silane groups very effectively without impairing the storage stability of silane group-containing polymers. Additionally, the silane is very tolerable in silane group-containing compositions, whereby such compositions are not prone to separate, migrate, or evaporate the catalyst.

  公式（I）中含有至少一个脂肪族酰胺基或含有酰胺基的胍基的烷氧基团的硅烷，以及生产同类产物的方法，以及将其用作固化组合物中的催化剂的用途，特别是基于含硅烷基的聚合物。公式（I）中的硅烷在室温下基本无味且不挥发。该硅烷有效加速硅烷基的水解和缩合反应，而不会影响含硅烷基聚合物的储存稳定性。此外，该硅烷在含硅烷基的组合物中具有很高的耐受性，因此这些组合物不容易分离、迁移或挥发出催化剂。

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