钾二乙基磷酸酯 | 53971-30-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: 钾二乙基磷酸酯
• 英文名称: potassium diethyl phosphate
• 英文别名: potassium;diethyl phosphate
• CAS: 53971-30-5
• 化学式: C₄H₁₀O₄P*K
• 分子量: 192.193
• InChiKey: CBVQYNAFBFUGTA-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.47
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  钾二乙基磷酸酯 、 α-溴-2,3,4,5,6-五氟甲基苯酸酯 在 18-冠醚-6 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成 O,O-diethyl phosphate pentafluorobenzyl ester
  参考文献：
  名称：

  粪便样品中O，O-二乙基磷酸酯和O，O-二乙基硫代磷酸酯的分析方法

  摘要：

  建立了一种残留分析方法，用于测定从兔子获得的粪便样品中对硫磷的二烷基磷酸酯代谢物。将粪便在水中均质化，然后通过相转移反应将高度水溶性的O，O-二乙基磷酸酯（DEP）和O，O-二乙基硫代磷酸酯（DETP）烷基化为五氟苄基酯。衍生化产率取决于反应时间。使用基质溶液中的可靠参考标准物在整个过程中确定回收率。使用GC-FPD时，参考标准可以观察样品基质对信号区域的影响。在0.05至5微克/克的浓度范围内，采用FPD的O，O-二乙基磷酸钾的回收率为47-62％，O，O-二乙基硫代磷酸钾盐的回收率为92-106％。

  DOI：

  10.1016/s0045-6535(00)00020-5
• 作为产物：
  描述：

  对硫磷(乙基对硫磷) 在 KF/Al₂O₃ 、 水 作用下， 以100%的产率得到钾二乙基磷酸酯
  参考文献：
  名称：

  Component Mobility by a Minute Quantity of the Appropriate Solvent as a Principal Motif in the Acceleration of Solid-Supported Reactions

  摘要：

  The effects solvents have on fluoride-promoted heterogeneous hydrolysis and alcoholysis of various organophosphorus (OP) compounds on the surface of KF/Al2O3 are described. Solid-state magic angle spinning NMR analyses and SEM microscopy have shown that not only is the identity of the solvent important in these reactions but also its quantity. That is, minimal solvent amounts are favored and much more effective in such solid-supported reactions (and maybe generally) than those featuring solvent-free or excess solvent (>50 wt %) conditions. The addition of a minute quantity of the correct solvent (3-10 wt %, molar equivalent scale) avoids reagents leaching from the matrix, permits mobility (mass transport) of the reaction components and ensures their very high local concentration in close proximity to the solid-support large porous surface area. Accordingly, significant acceleration of reactions rates by orders of magnitude is obtained. Fascinatingly, even challenging phosphoesters with poor leaving groups, which were found to be very stable in the presence of solvent-free KF/Al2O3 or wetted with,excess water, were efficiently hydrolyzed with a minute amount of this solvent.

  DOI：

  10.1021/acs.joc.5b00492

文献信息

• Compositions and methods of killing insects and acarids using
  申请人：Velsicol Chemical Corporation

  公开号：US03937824A1

  公开（公告）日：1976-02-10

  This invention discloses compounds of the formula ##EQU1## wherein R.sup.1 is alkyl; R.sup.2 is selected from the group consisting of hydrogen, alkyl, alkenyl, haloalkyl and cycloalkyl; R.sup.3 is selected from the group consisting of hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl and ##EQU2## WHEREIN D is selected from the group consisting of alkyl, alkenyl, alkoxy, alkylthio, halogen, haloalkyl, nitro and dialkylamino; and u is an integer from 0 to 3; X.sup.1, X.sup.2, X.sup.3 and X.sup.4 are independently selected from the group consisting of oxygen and sulfur; m and n are each integers from 0 to 1; Z.sup.1 is selected from the group consisting of alkyl, alkenyl and ##EQU3## WHEREIN A is selected from the group consisting of alkyl, alkenyl, alkoxy, alkylthio, haloalkyl, halogen, nitro, alkylsulfoxide, alkylsulfone and dialkylamino; and q and p are each integers from 0 to 3; Z.sup.2 is selected from the group consisting of hydrogen and Z.sup.1, provided that when Z.sup.2 is hydrogen then n is zero; and Y is selected from the group consisting of alkyl, alkenyl, alkoxy, alkenyloxy, alkylthio, amino, alkylamino, dialkylamino and ##EQU4## WHEREIN E is selected from the group consisting of alkyl, alkenyl, alkoxy, alkylthio, halogen, nitro, alkylsulfoxide, alkylsulfone and dialkylamino; f is an integer from 0 to 3; Q is selected from the group consisting of oxygen, sulfur, alkylene, alkyleneoxy and alkylenethio; and t is an integer from 0 to 1. The above compounds are useful as insecticides and acaricides.

  这项发明揭示了以下结构的化合物：其中R.sup.1为烷基；R.sup.2选自氢、烷基、烯基、卤代烷基和环烷基组成的群；R.sup.3选自氢、烷基、烯基、卤代烷基、环烷基和的群；其中D选自烷基、烯基、烷氧基、烷硫基、卤素、卤代烷基、硝基和二烷基氨基组成的群；u为0到3的整数；X.sup.1、X.sup.2、X.sup.3和X.sup.4独立选自氧和硫；m和n各自为0到1的整数；Z.sup.1选自烷基、烯基和的群；其中A选自烷基、烯基、烷氧基、烷硫基、卤代烷基、卤素、硝基、烷基亚砜、烷基砜和二烷基氨基组成的群；q和p各自为0到3的整数；Z.sup.2选自氢和Z.sup.1，但当Z.sup.2为氢时，n为零；Y选自烷基、烯基、烷氧基、烯基氧基、烷硫基、氨基、烷基氨基、二烷基氨基和的群；其中E选自烷基、烯基、烷氧基、烷硫基、卤素、硝基、烷基亚砜、烷基砜和二烷基氨基组成的群；f为0到3的整数；Q选自氧、硫、烷基、烷基氧基和烷基硫基；t为0到1的整数。上述化合物可用作杀虫剂和杀螨剂。
• Identification of products in the reaction of 2-[(hydroxyimino)methyl]-1,3-dimethylimidazolium iodide with diethyl 4-nitrophenyl phosphate in alkaline medium
  作者：I. V. Kapitanov、A. A. Abakumov、A. A. Serdyuk

  DOI：10.1134/s1070428015100024

  日期：2015.10

  Products of the reaction of 2-[(hydroxyimino)methyl]-1,3-dimethylimidazolium iodide with diethyl 4-nitrophenyl phosphate in alkaline medium have been identified by electronic spectroscopy, one-(1H, 31P, 13C) and two-dimensional (1H–1H COSY, 1H–31P HMBC) NMR techniques, and NMR titration. 2-[(Hydroxyimino)-methyl]-1,3-dimethylimidazolium iodide has been found to act as nucleophile which is likely to

  通过电子光谱鉴定了2-[（（羟基亚氨基）甲基] -1,3-碘化咪唑鎓碘化物与4-乙基硝基苯基磷酸二乙酯在碱性介质中的反应产物，一种-（1 H，31 P，13 C）和两种维（1 H– 1 H COSY，1 H– 31P HMBC）NMR技术和NMR滴定。已经发现2-[（羟基亚氨基）-甲基] -1，3-二甲基咪唑碘化物起亲核试剂的作用，它很可能被转化成2-氰基-1，3-二甲基咪唑鎓。其他产物是4-硝基苯酚和磷酸二乙酯磷酸氢盐。已经排除了其他反应途径，例如2-（（羟基亚氨基）甲基] -1，3-二甲基咪唑碘化物对磷酸二乙基4-硝基苯基酯水解的亲核催化和形成稳定的磷酸化产物。
• Preparation of anhydrous organic acid salts
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US04723016A1

  公开（公告）日：1988-02-02

  One-step process for preparing anhydrous, organic acid alkali or alkaline earth metal salts by contacting and reacting an organic or polymeric acid fluoride, anhydride or ester and an organic alkali or alkaline earth metal silanolate.

  通过将有机或聚合酸氟化物、酸酐或酯与有机碱或碱土金属硅醇盐接触并反应，制备无水有机酸碱或碱土金属盐的一步法过程。
• <i>p</i>-Hydroxyphenacyl photoremovable protecting groups — Robust photochemistry despite substituent diversity
  作者：Richard S. Givens、Kenneth Stensrud、Peter G. Conrad、Abraham L. Yousef、Chamani Perera、Sanjeewa N. Senadheera、Dominik Heger、Jakob Wirz

  DOI：10.1139/v10-143

  日期：2011.2

  A broadly based investigation of the effects of a diverse array of substituents on the photochemical rearrangement of p-hydroxyphenacyl esters has demonstrated that common substituents such as F, MeO, CN, CO₂R, CONH₂, and CH₃have little effect on the rate and quantum efficiencies for the photo-Favorskii rearrangement and the release of the acid leaving group or on the lifetimes of the reactive triplet state. A decrease in the quantum yields across all substituents was observed for the release and rearrangement when the photolyses were carried out in buffered aqueous media at pHs that exceeded the ground-state pK_aof the chromophore where the conjugate base is the predominant form. Otherwise, substituents have only a very modest effect on the photoreaction of these robust chromophores.

  一项关于各种取代基对对羟基苯乙酯光化学重排影响的广泛研究表明，常见取代基（如 F、MeO、CN、CO2R、CONH2 和 CH3）对光-Favorskii 重排和酸离去基团释放的速率和量子效率影响很小，对反应三重态的寿命影响也很小。当光解在缓冲水介质中进行时，pH 值超过发色团的基态 pKao（其中共轭碱是主要形式），则释放和重排的量子产率在所有取代基中都会降低。否则，取代基对这些坚固发色团的光反应影响很小。
• Five‐Step Enantioselective Synthesis of Islatravir via Asymmetric Ketone Alkynylation and an Ozonolysis Cascade
  作者：Niki R. Patel、Mark A. Huffman、Xiao Wang、Bangwei Ding、Mark McLaughlin、Justin A. Newman、Teresa Andreani、Kevin M. Maloney、Heather C. Johnson、Aaron M. Whittaker

  DOI：10.1002/chem.202003091

  日期：2020.11.6

  enantioselective synthesis of the potent anti‐HIV nucleoside islatravir is reported. The highly efficient route was enabled by a novel enantioselective alkynylation of an α,β‐unsaturated ketone, a unique ozonolysis‐dealkylation cascade in water, and an enzymatic aldol‐glycosylation cascade.

  据报道，有效的抗HIV核苷依斯拉韦的5步对映选择性合成。新型α，β-不饱和酮的对映选择性炔基化，水中独特的臭氧分解脱烷基级联和酶促醛缩糖基化级联可实现高效途径。