TEMPERATURE-RESPONSIVE BASE MATERIAL, METHOD FOR PRODUCING SAME, AND METHOD FOR EVALUATING SAME
申请人:Daikin Industries, Ltd.
公开号:EP3101116A1
公开(公告)日:2016-12-07
An object of the present invention is to provide a temperature-responsive cell culture having the following excellent properties: (1) an object adhered to its surface (e.g., cells) can be more easily detached; and/or (2) a sheet adhered to its surface (e.g., a cell sheet) can be detached with less damage; and/or (3) the substrate has a lower LCST than that of conventional substrates, and is easier to handle. Another object of the invention is to provide (4) a method for evaluating a temperature-responsive substrate for the above properties. The present invention provides a temperature-responsive substrate having on its surface a layer containing at least one polymer, the at least one polymer being responsive to temperature and containing a fluorine-containing monomer-derived unit.
本发明的一个目的是提供一种温度响应型细胞培养物,该培养物具有以下优良特性:(1)粘附在其表面的物体(如细胞)更容易剥离;和/或(2)粘附在其表面的薄片(如细胞薄片)剥离时损伤更小;和/或(3)该基底的LCST低于传统基底的LCST,更容易处理。本发明的另一个目的是提供(4)一种评估温度响应基底上述特性的方法。本发明提供了一种温度响应基底,其表面有一层含有至少一种聚合物的层,该至少一种聚合物对温度响应,并含有含氟单体衍生单元。