2,2,3-三羟基十八烷酸 | 26248-23-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2,2,3-三羟基十八烷酸
• 英文名称: Octadecanoic acid, trihydroxy-
• 英文别名: 2,2,3-trihydroxyoctadecanoic acid
• CAS: 26248-23-7
• 化学式: C₁₈H₃₆O₅
• 分子量: 332.5
• InChiKey: UFNQGWYXYWLWMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  23
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• [EN] LIPIDS FOR DELIVERY OF CHARGED MATERIAL, FORMULATIONS THEREOF AND METHOD FOR MAKING SAME<br/>[FR] LIPIDES POUR L'ADMINISTRATION D'UN MATÉRIAU CHARGÉ, LEURS FORMULATIONS ET LEUR PROCÉDÉ DE FABRICATION
  申请人：INTEGRATED NANOTHERAPEUTICS INC

  公开号：WO2021026647A1

  公开（公告）日：2021-02-18

  Disclosed herein is a lipid having a net charge at physiological pH, and being covalently attached to a lipid moiety. The lipid moiety comprises a hydrocarbon structure having two or more linked hydrocarbon chains, optionally having cis or trans C=C, at least one of said chains being covalently attached to the head group optionally via the linker region. The hydrocarbon chains are bonded to one another at a branch point at an internal carbon of the chain attached to the linker region, which branch point comprises a functional group having an electronegative atom. The hydrocarbon chains each have between 1 and 40 carbon atoms, wherein the hydrocarbon structure in total comprises between 10 and 150 carbon atoms. Advantageously, the hydrocarbon structure may assume a generally flared shape for enhanced delivery of cargo molecules. Further provided are delivery vehicles comprising the lipids.

  本文揭示了一种在生理pH下具有净电荷的脂质，且与脂质部分共价连接。脂质部分包括具有两个或更多个连接的碳氢链的碳氢结构，可选择具有顺式或反式C=C，其中至少一个链通过连接区域共价连接到头基。碳氢链在连接到连接区域的链的内部碳上相互连接在一个分支点上，该分支点包括具有电负原子的功能基团。每个碳氢链具有1至40个碳原子，其中总的碳氢结构包括10至150个碳原子。优点是，碳氢结构可以呈现一种通常呈扩张形状以增强货物分子的输送。此外，提供了包含这些脂质的输送载体。
• CONTROLLED RELEASE ANTIMICROBIAL COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS
  申请人：LICHTER Jay

  公开号：US20100036000A1

  公开（公告）日：2010-02-11

  Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

  本文公开了用抗微生物药物组合物和制剂治疗耳疾或病症的组合物和方法，通过将这些组合物和制剂直接应用于或通过灌注进入目标耳结构，局部治疗患有耳疾或病症的个体。
• AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS
  申请人：LICHTER Jay

  公开号：US20090306225A1

  公开（公告）日：2009-12-10

  Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

  本文公开了使用免疫调节剂和耳压调节剂治疗耳部疾病的组合物和方法。在这些方法中，通过将免疫调节剂和/或耳压调节剂组合物和配方直接应用于耳媒介和/或耳内靶区，或通过灌注进入耳媒介和/或耳内结构，局部给患有耳部疾病的个体进行治疗。
• Controlled Release Antimicrobial Compositions and Methods for the Treatment of Otic Disorders
  申请人：Otonomy, Inc.

  公开号：US20150150793A1

  公开（公告）日：2015-06-04

  Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

  本文公开了一种使用抗微生物剂组合物和制剂局部治疗患有耳疾或状况的个体的方法和组合物，通过将这些组合物和制剂直接应用于或通过灌注进入目标耳结构。
• Auris Formulations for Treating Otic Diseases and Conditions
  申请人：Otonomy, Inc.

  公开号：US20160228357A1

  公开（公告）日：2016-08-11

  Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

  本文介绍了使用免疫调节剂和耳压调节剂治疗耳部疾病的组合物和方法。在这些方法中，通过直接将免疫调节剂和/或耳压调节剂组合物和配方局部应用于患有耳部疾病的个体的耳媒体和/或耳内靶区，或通过灌注到耳媒体和/或耳内结构中。