2-(4-fluoro-2-methylanilino)-N-[4-(trifluoromethyl)phenyl]acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(4-fluoro-2-methylanilino)-N-[4-(trifluoromethyl)phenyl]acetamide
• 化学式: C₁₆H₁₄F₄N₂O
• 分子量: 326.29
• InChiKey: UVJVXKZXTPZJSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• BROAD SPECTRUM ANTIVIRULENCE, ANTI-PERSISTENCE COMPOUNDS
  申请人：RAHME Laurence

  公开号：US20210130306A1

  公开（公告）日：2021-05-06

  The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or relapsing infections. Pharmaceutical compositions, methods of treating diseases (e.g., bacterial infections), and methods of reducing bacterial virulence are also provided.
• [EN] BROAD SPECTRUM ANTIVIRULENCE, ANTI-PERSISTENCE COMPOUNDS<br/>[FR] COMPOSÉS ANTI-PERSISTANCE ET ANTI-VIRULENCE À LARGE SPECTRE
  申请人：RAHME LAURENCE

  公开号：WO2019079759A1

  公开（公告）日：2019-04-25

  The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or relapsing infections. Pharmaceutical compositions, methods of treating diseases (e.g., bacterial infections), and methods of reducing bacterial virulence are also provided.