2,2-二氯戊二酸 | 50901-13-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2,2-二氯戊二酸
• 英文名称: 2,2-dichloro-1,5-pentanedioic acid
• 英文别名: α,α-Dichlorglutarsaeure；2,2-Dichloropentanedioic acid
• CAS: 50901-13-8
• 化学式: C₅H₆Cl₂O₄
• 分子量: 201.006
• InChiKey: XFNCLICUOWQWLG-UHFFFAOYSA-N

物化性质

• 沸点：
  324.7±42.0 °C(Predicted)
• 密度：
  1.632±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2-二氯戊二酸 生成 alpha-酮戊二酸
  参考文献：
  名称：

  NAJZAREK, Z.

  摘要：

  DOI：
• 作为产物：
  描述：

  α,α-Dichlor-glutarsaeure-diethylester 生成 2,2-二氯戊二酸
  参考文献：
  名称：

  NAJZAREK, Z.

  摘要：

  DOI：

文献信息

• Process for preparation of L-Arginine alpha-ketoglutarate 1:1 and 2:1
  申请人：Zhang Guoji

  公开号：US20120095260A1

  公开（公告）日：2012-04-19

  A process for preparation of α-ketoglutaric acid, L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: providing a α-ketoglutaratic acid aqueous solution at an adjusted concentration; adding one equivalent mole of solid L-arginine to the α-ketoglutaratic acid aqueous solution; stirring and allowing reaction under a controlled temperature; (e) obtaining a resulting L-arginine α-ketoglutarate 1:1 solution with a pH of approximately 3˜4 or L-arginine α-ketoglutarate 2:1 solution with a pH of approximately 6.5˜7; and obtaining a final product of L-arginine α-ketoglutarate 1:1 or 2:1 through spay drying. The yield of the final product is approximately 94% for L-arginine α-ketoglutarate 1:1 and 97% for L-arginine α-ketoglutarate 2:1 through the process. Large amount of solvents is eliminated and reaction time is shortened but the yield is increased, hence realizing mass production through reactor in a cost and time effective manner.

  一种制备α-酮戊二酸、L-精氨酸α-酮戊二酸1:1和2:1的方法，包括以下步骤：提供调整浓度的α-酮戊二酸水溶液；将一个当量的固体L-精氨酸加入α-酮戊二酸水溶液中；搅拌并在控制温度下进行反应；得到pH约为3˜4的L-精氨酸α-酮戊二酸1:1溶液或pH约为6.5˜7的L-精氨酸α-酮戊二酸2:1溶液；并通过喷雾干燥获得最终产品L-精氨酸α-酮戊二酸1:1或2:1。该过程的产率为L-精氨酸α-酮戊二酸1:1约为94％，L-精氨酸α-酮戊二酸2:1约为97％。消除了大量溶剂，缩短了反应时间，但提高了产率，因此通过反应器实现了成本和时间上的大规模生产。
• Process for preparation of alpha-ketoglutaric acid
  申请人：Zhang Guoji

  公开号：US20120095261A1

  公开（公告）日：2012-04-19

  A process for preparation of α-ketoglutaric acid, which is adapted for preparing L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: (a) reacting methyl dichloroacetate and acrylic acid methyl ester with sodium methoxide to obtain dimethyl 2,2-dichloroglutarate; (b) reacting the dimethyl 2,2-dichloroglutarate from step (a) with hydroxide solution to obtain crude α-ketoglutaratic acid aqueous solution; (c) purifying the crude α-ketoglutaratic acid aqueous solution to obtain purified α-ketoglutaratic acid aqueous solution; and (d) adjusting a concentration of the purified α-ketoglutaratic acid aqueous solution by adding water, thereby a yield of the purified α-ketoglutaratic acid aqueous solution is approximately 75%. While avoiding the use of massive organic solvents, the process of the present invention has a remarkable high yield to realize mass production with low manufacturing cost and shortened production time.

  一种制备α-酮戊二酸的方法，适用于制备L-精氨酸α-酮戊二酸1:1和2:1，包括以下步骤：(a)将二氯乙酸甲酯和丙烯酸甲酯与甲氧基钠反应，得到二甲基2,2-二氯戊二酸酯；(b)将步骤(a)中得到的二甲基2,2-二氯戊二酸酯与氢氧化物溶液反应，得到粗α-酮戊二酸水溶液；(c)纯化粗α-酮戊二酸水溶液，得到纯化的α-酮戊二酸水溶液；(d)通过加水调节纯化的α-酮戊二酸水溶液的浓度，从而获得纯化的α-酮戊二酸水溶液的收率约为75%。本发明的方法避免了使用大量的有机溶剂，具有显著的高收率，能够实现低成本的大规模生产并缩短生产时间。
• Process for preparation of l-arginine alpha-ketoglutarate 1:1 and 2:1
  申请人：Zhang Guoji

  公开号：US20140187815A1

  公开（公告）日：2014-07-03

  A process for preparation of α-ketoglutaric acid, L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: providing a α-ketoglutaratic acid aqueous solution at an adjusted concentration; adding one equivalent mole of solid L-arginine to the α-ketoglutaratic acid aqueous solution; stirring and allowing reaction under a controlled temperature; (e) obtaining a resulting L-arginine α-ketoglutarate 1:1 solution with a pH of approximately 3˜4 or L-arginine α-ketoglutarate 2:1 solution with a pH of approximately 6.5˜7; and obtaining a final product of L-arginine α-ketoglutarate 1:1 or 2:1 through spay drying. The yield of the final product is approximately 94% for L-arginine α-ketoglutarate 1:1 and 97% for L-arginine α-ketoglutarate 2:1 through the process. Large amount of solvents is eliminated and reaction time is shortened but the yield is increased, hence realizing mass production through reactor in a cost and time effective manner.

  一种制备α-酮戊二酸、L-精氨酸α-酮戊二酸1:1和2:1的方法，包括以下步骤：提供调整浓度的α-酮戊二酸水溶液；向α-酮戊二酸水溶液中加入等当量的固体L-精氨酸；在控制温度下搅拌和反应；获得pH约为3~4的L-精氨酸α-酮戊二酸1:1溶液或pH约为6.5~7的L-精氨酸α-酮戊二酸2:1溶液；通过喷雾干燥获得最终的L-精氨酸α-酮戊二酸1:1或2:1产品。通过该过程，L-精氨酸α-酮戊二酸1:1的产率约为94％，L-精氨酸α-酮戊二酸2:1的产率约为97％。该方法消除了大量溶剂，缩短了反应时间，但提高了产率，从而以成本和时间有效的方式通过反应器实现大规模生产。
• A polycarbonate resin composition
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0694581A2

  公开（公告）日：1996-01-31

  A thermoplastic polycarbonate resin composition having high compatibility and outstanding low-temperature impact resistance and tensile elongation comprises (A) 5-50 parts by weight of poly(methyl methacrylate), (B) 70-30 parts by weight of polycarbonate obtained by melt polymerization of an aromatic dihydroxy compound and a carbonic acid diester in which the equivalence ratio (I)/(II) of phenolic end groups (I) and non-phenolic end groups (II) is 1/19 or above, and (C) 1-40 parts by weight of an impact-resistance-improving agent.

  一种热塑性聚碳酸酯树脂组合物具有高相容性和出色的低温抗冲击性和拉伸伸长率，它包括 (A) 5-50 份（按重量计）聚甲基丙烯酸甲酯、(B) 70-30 份（按重量计）由芳香族二羟基化合物和碳酸二酯熔融聚合而得的聚碳酸酯，其中酚醛端基（I）和非酚醛端基（II）的当量比（I）/（II）为 1/19 或以上；以及 (C) 1-40 份（按重量计）抗冲击性改进剂。
• A glass-fiber-reinforced polycarbonate resin composition
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0694582A2

  公开（公告）日：1996-01-31

  A glass-fiber-reinforced polycarbonate resin composition having high compatibility and outstanding mechanical properties comprises (A) 10-50 parts by weight of poly(methylmethacrylate), (B) 30-60 parts by weight of polycarbonate obtained by melt polymerization of an aromatic dihydroxy compound and a carbonic acid diester in which the equivalence ratio (I)/(II) of phenolic end groups (I) and non-phenolic end groups (II) is 1/19 or above, (C) 2-40 parts by weight of an impact-resistance-improving agent and (D) 10-40 parts by weight of glass fibers.

  一种玻璃纤维增强型聚碳酸酯树脂组合物具有高兼容性和出色的机械性能，它包括 (A) 10-50 份(重量)聚甲基丙烯酸甲酯、(B) 30-60 份（按重量计）通过芳香族二羟基化合物和碳酸二酯的熔融聚合得到的聚碳酸酯，其中酚醛端基（I）和非酚醛端基（II）的当量比（I）/（II）为 1/19 或以上； (C) 2-40 份（按重量计）抗冲击性改进剂；以及 (D) 10-40 份（按重量计）玻璃纤维。