N,N'-bis-(4-methoxy-benzylidenamino)-guanidine | 72463-14-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N,N'-bis-(4-methoxy-benzylidenamino)-guanidine
• 英文别名: N,N'-Bis-(4-methoxy-benzylidenamino)-guanidin；1,2-bis[(E)-(4-methoxyphenyl)methylideneamino]guanidine
• CAS: 72463-14-0
• 化学式: C₁₇H₁₉N₅O₂
• 分子量: 325.37
• InChiKey: DCTPWFFEWAUYCX-AYKLPDECSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  93.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• DIAMINOGUANIDINE DERIVATIVES AND APPLICATION THEREOF IN PREPARATION OF ANIMAL GROWTH PROMOTERS USED IN FEED
  申请人：GUANGZHOU INSIGHTER BIOTECHNOLOGY CO., LTD.

  公开号：US20160340299A1

  公开（公告）日：2016-11-24

  Diaminoguanidine derivatives in preparation of animal growth promoters used in feed. The diaminoguanidine derivatives have a structural formula as shown in formula (I), wherein R 1 is methyl, ethyl, isopropyl, n-butyl, n-propyl, n-pentyl, n-octyl, n-tetradecyl, sec-butyl, 3-pentyl, cyclopentyl or benzyl. The diaminoguanidine compounds significantly improve the productivity of ducks if they are fed with the diaminoguanidine compounds. Productivity of pigs or chickens is also improved with such diaminoguanidine compounds.

  二胺基胍衍生物用于制备用于饲料中的动物生长促进剂。二胺基胍衍生物具有如下所示的结构式（I），其中R1为甲基、乙基、异丙基、正丁基、正丙基、正戊基、正辛基、正十四烷基、仲丁基、3-戊基、环戊基或苄基。如果鸭子被喂食二胺基胍化合物，则这些化合物显著提高了鸭子的生产力。使用这种二胺基胍化合物也可以提高猪或鸡的生产力。
• ROBENIDINE ANALOGS AS POTENT ANTIMALARIALS AGAINST DRUG-RESISTANT PLASMODIUM FALCIPARUM
  申请人：OREGON HEALTH & SCIENCE UNIVERSITY

  公开号：US20220267258A1

  公开（公告）日：2022-08-25

  Provided herein is a compound of Formula (I): wherein: R 1 is selected from the group of —F, —Cl, —Br, —I, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, —NO 2 , —C(H)═O, ═O, —CN, and COOR 3 ; R 2 is selected from the group of H and C 1 -C 3 alkyl; and R 3 is selected from the group of H, C 1 -C 6 alkyl, and benzyl; or a pharmaceutically acceptable salt, co-crystal, ester, solvate, hydrate, isomer (including optical isomers, racemates, or other mixtures thereof), tautomer, isotope, polymorph, or pharmaceutically acceptable prodrug thereof, along with pharmaceutical compositions and methods of using the compound in the treatment of malaria, particularly including drug-resistant malaria.

  提供的是化合物I的公式：其中：R1选自—F，—Cl，—Br，—I，C1-C6卤代烷基，C1-C6卤代氧烷基，—NO2，—C（H）═O，═O，—CN和COOR3的组；R2选自H和C1-C3烷基；R3选自H，C1-C6烷基和苄基；或其药学上可接受的盐，共晶体，酯，溶剂合物，水合物，异构体（包括光学异构体，外消旋体或其他混合物），互变异构体，同位素，多晶形或其药学上可接受的前药，以及使用该化合物治疗疟疾的药物组合物和方法，特别是包括耐药性疟疾。
• Compounds and methods of treating infections
  申请人：Neoculi Pty Ltd.

  公开号：US10370341B2

  公开（公告）日：2019-08-06

  The invention provides compounds of Formula I, and methods of treating or preventing a bacterial infection in a subject using a compound of Formula I. The invention also provides the use of a compound of Formula I in the manufacture of a medicament for the treatment of a bacterial infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a bacterial infection in a subject and to a medical device comprising the composition of the invention.

  本发明提供了式 I 化合物，以及使用式 I 化合物治疗或预防受试者细菌感染的方法。本发明还提供了式 I 化合物在制造治疗受试者细菌感染的药物中的用途。本发明进一步提供了一种用于治疗或预防受试者细菌感染方法中的医疗器械，以及包含本发明组合物的医疗器械。
• COMPOUNDS AND METHODS OF TREATING INFECTIONS
  申请人：Neoculi Pty Ltd

  公开号：EP2991968B1

  公开（公告）日：2021-11-10
• METHODS FOR TREATING PROTOZOAN INFECTIONS
  申请人：Neoculi Pty Ltd

  公开号：EP3188722B1

  公开（公告）日：2021-08-04