2,2-双(4-氟苯基)环氧乙烷 | 82144-12-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,2-双(4-氟苯基)环氧乙烷
• 英文名称: 2,2-bis(4-fluorophenyl)oxirane
• 英文别名: 1,1-bis-(4-fluorophenyl)-ethylene oxide
• CAS: 82144-12-5
• 化学式: C₁₄H₁₀F₂O
• 分子量: 232.23
• InChiKey: BDIDQKAXFZIVLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2-双(4-氟苯基)环氧乙烷 在 trifluoroborane diethyl ether 作用下， 以 甲苯 为溶剂， 生成 2,2-bis(4-fluorophenyl)acetaldehyde
  参考文献：
  名称：

  Isochromane derivatives

  摘要：

  该发明涉及一种异色满烷衍生物，其具有一般式I ##STR1## 其中R.sub.1是独立选自氢、羟基、烷基（1-4 C）、烷氧基（1-4 C）、卤素或CF.sub.3的1-4个取代基，或作为两个相邻取代基一起是一个亚甲二氧基基团；R.sub.2是独立选自氢、羟基、烷基（1-4 C）、烷氧基（1-4 C）、卤素或CF.sub.3的1-4个取代基，或作为两个相邻取代基一起是一个亚甲二氧基基团；R.sub.3是独立选自氢、羟基、烷基（1-4 C）、烷氧基（1-4 C）、卤素或CF.sub.3的1-4个取代基，或作为两个相邻取代基一起是一个亚甲二氧基基团；R.sub.4选自氢或烷基（1-4 C）；A是键或具有1-6个碳原子的烷基或烷基亚甲基基团；当Y是键时，B是具有1-6个碳原子的烷基或烷基亚甲基基团，或当Y是从O、S或NR.sub.5中选取的基团时，B是具有2-6个碳原子的烷基基团；X是CH或N；R.sub.5选自氢或烷基（1-4 C）；或其药学上可接受的盐。这些化合物可用于治疗心绞痛、心律失常、心肌病、中风和心肌梗塞。

  公开号：

  US05238939A1
• 作为产物：
  描述：

  对氟苯基锂 、 2-氯代-4'-氟苯乙酮 以 四氢呋喃 为溶剂， 生成 2,2-双(4-氟苯基)环氧乙烷
  参考文献：
  名称：

  Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity

  摘要：

  The synthesis, biological evaluation, and structure-activity relationships of a series of 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols are described. These compounds show potent dose-dependent topical antiinflammatory activity in murine models of skin inflammation. This effect is likely due to inhibition of cytochrome P450 and consequent reduction in levels of 12R-HETE in the skin. These compounds were examined for their ability to inhibit the oxidative metabolism of arachidonic acid; they specifically inhibit the formation of prostacyclins in mouse macrophages. To study the effects of structure on the in vivo activity, three general features of the molecules were varied: the position of attachment of the pyridine nucleus (A), the second aromatic residue (B), and the nitrogen base on the ethanol chain (C). 1-[4-(4-Pyridyl)phenyl]-1-(4-fluorophenyl)-2-imidazolylethanol (2a, DuP 983) shows a very attractive profile of antiinflammatory activity and has been selected for clinical evaluation as a topical antiinflammatory agent.

  DOI：

  10.1021/jm00095a009

文献信息

• Copper-catalyzed benzylic C(sp³)–H alkoxylation of heterocyclic compounds
  作者：Noriaki Takemura、Yoichiro Kuninobu、Motomu Kanai

  DOI：10.1039/c4ob00215f

  日期：——

  We achieved intra- and intermolecular C(sp3)–H alkoxylation of benzylic positions of heteroaromatic compounds using CuBrn (n = 1, 2)/5,6-dimethylphenanthroline (or 4,7-dimethoxyphenanthroline) and (tBuO)2 as a catalyst and an oxidant, respectively. The reaction proceeded at both terminal and internal benzylic positions of the alkyl groups. The intramolecular alkoxylation was performed on a gram scale

  我们使用CuBr n（n = 1，2）/ 5,6-二甲基菲咯啉（或4,7-二甲氧基菲咯啉）和（t BuO）2实现了杂芳族化合物苄基位置的分子内和分子间C（sp 3）-H烷氧基化分别作为催化剂和氧化剂。反应在烷基的末端和内部苄基位置上进行。分子内烷氧基化以克为单位进行。
• Ethers on esters of 1-triazole-2-substituted ethanols
  申请人：Imperial Chemical Industries PLC

  公开号：US04880457A1

  公开（公告）日：1989-11-14

  A compound of general formula (1) ##STR1## wherein R.sup.1 is C.sub.1-6 alkyl, cyclobutyl, cyclopropyl, cyclopentyl cyclohexyl or phenyl, and R.sup.2 is phenyl or benzyl; the phenyl of R.sup.1 and the phenyl or phenyl moiety of the benzyl of R.sup.2 being optionally substituted with halogen, C.sub.1-6 alkyl, C.sub.1-5 alkoxy, C.sub.1-10 alkoxyalkyl, halo-C.sub.1-4 alkyl, halo-C.sub.1-4 alkoxy, halo-.sub.1-5 alkoxy, halo-C.sub.1-5 alkyl, nitro, phenyl, phenoxy, benzyl, optionally halo-substituted benzyloxy, C.sub.1-2 alkylenedioxy, acetylamino, halo-C.sub.1-2 alkylenedioxy, amino, mono- or di-C.sub.1-4 alkylamino, hydroxy, cyano, morpholino or carboxy or an alkyl ester thereof, and/or the alkyl moiety of the benzyl is optionally substituted with one C.sub.1-4 alkyl; and acid addition salts, ethers, esters and metal complexes thereof. The compounds are useful as fungicides and as plant growth regulating agents.

  一种通式（1）的化合物##STR1##其中R.sup.1是C.sub.1-6烷基、环丁基、环丙基、环戊基、环己基或苯基，R.sup.2是苯基或苄基；R.sup.1的苯基和R.sup.2的苯基或苄基的苯基可以选择性地用卤素、C.sub.1-6烷基、C.sub.1-5烷氧基、C.sub.1-10烷氧基烷基、卤代C.sub.1-4烷基、卤代C.sub.1-4烷氧基、卤代C.sub.1-5烷氧基、卤代C.sub.1-5烷基、硝基、苯基、苯氧基、苄基、可以选择性卤代的苄氧基、C.sub.1-2烷二氧基、乙酰氨基、卤代C.sub.1-2烷二氧基、氨基、单或双C.sub.1-4烷基氨基、羟基、氰基、吗啉基或羧基或其烷基酯，和/或苄基的烷基可以选择性地用一个C.sub.1-4烷基取代；以及它们的酸盐、醚、酯和金属配合物。这些化合物可用作杀菌剂和植物生长调节剂。
• [EN] TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS<br/>[FR] COMPOSÉS TRIAZOLO TRICYCLIQUES UTILISÉS COMME INHIBITEURS DE DGK
  申请人：INCYTE CORP

  公开号：WO2023239768A1

  公开（公告）日：2023-12-14

  The present application provides tricyclic triazolo compounds I that modulate the activity of diacylglycerol kinase (DGK), which are useful in the treatment of various diseases, including cancer.

  本申请提供了调节二酰甘油激酶（DGK）活性的三环三唑化合物 I，可用于治疗包括癌症在内的各种疾病。
• Triazole compounds, a process for preparing them, their use as plant fungicides and plant growth regulators and compositions containing them
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0047594A2

  公开（公告）日：1982-03-17

  Compounds of formula: and stereoisomers thereof, wherein R1 is alkyl, cycloalkyl or optionally substituted phenyl and R2 is phenyl or benzyl, each optionally substituted; and their acid addition salts, ethers, esters and metal complexes; have fungicidal and plant growth regulating activity.

  式化合物及其立体异构体 及其立体异构体，其中 R1 是烷基、环烷基或任选取代的苯基，R2 是苯基或苄基，各自任选取代；以及它们的酸加成盐、醚、酯和金属络合物；具有杀菌和植物生长调节活性。
• Use of triazolylethanol derivatives and their compositions as non-agricultural fungicides
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0131684B1

  公开（公告）日：1992-03-11