2,2’-(乙烯基二亚氨基)二丁酸 | 498-17-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2,2’-(乙烯基二亚氨基)二丁酸
• 中文别名: 2,2'-(乙烯二亚氨基)-二丁酸；2,2'-(乙烯基二亚氨基)二丁酸
• 英文名称: 2,2'-(ethylenediimino)di-2-butanoic acid
• 英文别名: 2,2'-(ethylenediimino)dibutyric acid；ethylenebis(2-aminobutyric acid)；2,2'-(ethylenediimino)-dibutyric acid；2,2'-(ethylendiimino)-dibutyric acid；Ethylendiamin-N,N'-(2,2-dibuter)saeure；2-[2-(1-carboxypropylamino)ethylamino]butanoic acid
• CAS: 498-17-9
• 化学式: C₁₀H₂₀N₂O₄
• 分子量: 232.28
• InChiKey: LLOPSLUNSGBASE-UHFFFAOYSA-N

物化性质

• 熔点：
  >271°C (dec.)
• 溶解度：
  酸水溶液（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  98.7
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  2,2’-(乙烯基二亚氨基)二丁酸 、 cobalt(II) chloride 在 air 、 乙醇 作用下， 以 水 为溶剂， 生成 dicobalt(III)(ethylenebis(aminobutyric acidate))2(μ-peroxo)(μ-hydroxo)(1-)*Na(1+)
  参考文献：
  名称：

  Stereochemical control of oxygen activation in synthetic oxygen carriers

  摘要：

  DOI：

  10.1016/0304-5102(88)80051-8
• 作为产物：
  描述：

  2,2'-(1,2-Ethanediyl(N,N'-dibenzoyl)diimino)bis-butanenitrile 在 盐酸 作用下， 生成 2,2’-(乙烯基二亚氨基)二丁酸
  参考文献：
  名称：

  Iyer, Radhakrishnan P.; Lawate, Saurabh S.; Sonaseth, Mariam S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 1, p. 3 - 4

  摘要：

  DOI：

文献信息

• COMPOSITION AND METHOD FOR TREATING SKIN CONDITIONS
  申请人：Zo Skin Health, Inc.

  公开号：EP3278794A1

  公开（公告）日：2018-02-07

  A topical composition, comprising: an inflammatory management agent comprising lactose and/or milk protein, the inflammatory management agent being present in an amount of from about 0.01 wt. % to about 12.5 wt. % based on the weight of the topical composition; a vascular repair agent comprising palmitoyl glycine, the vascular repair agent being present in an amount of from about 0.01 wt. % to about 15 wt. % based on the weight of the topical composition; a neurogenic agent comprising an oligosaccharide, the neurogenic agent being present in an amount of from about 0.01 wt. % to about 22.5 wt. % based on the weight of the topical composition; a sebum suppression agent comprising Panthenyl Triacetate, farnesol and farnesyl acetate, the sebum suppression agent being present in an amount of from about 0.01 wt. % to about 25 wt. % based on the weight of the topical composition; and an exfoliating agent comprising at least one plant derived cysteine protease enzyme, the exfoliating agent being present in an amount of from about 0.01 wt. % to about 10 wt. % based on the weight of the topical composition.

  一种外用组合物，包含：一种炎症控制剂，包含乳糖和/或牛奶蛋白，该炎症控制剂的含量为约 0.01 wt.% ；血管修复剂，包括棕榈酰甘氨酸，该血管修复剂的含量为约 0.01 wt.01 wt. %至约 22.5 wt. %，以外用组合物的重量为基数；一种皮脂抑制剂，包括三乙酸泛苯酯、法呢醇和乙酸法呢酯，以外用组合物的重量为基数，该皮脂抑制剂的含量为约 0.01 wt.去角质剂包括至少一种植物提取的半胱氨酸蛋白酶，去角质剂的用量为约 0.01 重量百分比至约 10 重量百分比（基于外用组合物的重量）。
• Reduced dose intravenous acetaminophen
  申请人：MALLINCKRODT HOSPITAL PRODUCTS IP LIMITED

  公开号：US10383834B2

  公开（公告）日：2019-08-20

  Described herein are compositions and methods for intravenous administration of acetaminophen at a single dose level of less than about 1000 mg for the treatment or prevention of pain (e.g., postoperative pain) and/or fever.

  本文描述了用于静脉注射对乙酰氨基酚的组合物和方法，单次剂量水平小于约 1000 毫克，用于治疗或预防疼痛（如术后疼痛）和/或发热。
• Method for reducing lung infection
  申请人：Respirion Pharmaceuticals Pty Ltd

  公开号：US11382884B2

  公开（公告）日：2022-07-12

  A method of treating or preventing a bacterial infection in the lung of a subject by administering an inhaled antibiotic, and at least 37.5 mg/day of an inhaled chelating agent, each in one or more doses, wherein the or each dose of the chelating agent and/or antibiotic is administered over a period of no more than 8h.

  一种治疗或预防受试者肺部细菌感染的方法，该方法通过施用一种吸入式抗生素和至少 37.5 毫克/天的吸入式螯合剂，每种螯合剂的剂量为一次或多次，其中螯合剂和/或抗生素的施用时间不超过 8 小时。
• Antimicrobial wash and carrier solutions, and uses thereof
  申请人：——

  公开号：US20040071769A1

  公开（公告）日：2004-04-15

  Novel wash and carrier solutions ideally suited for topical administration (e.g., as wash solutions and as carrier solutions). The solutions described herein arc non-toxic, non-irritating, isotonic, possess non-specific broad-spectrum antimicrobial properties, and have an alkaline pH. Also disclosed are sterile preparations of the solutions and methods of using the same.

  新型清洗液和载体溶液非常适合局部用药（如作为清洗液和载体溶液）。所述溶液无毒、无刺激、等渗、具有非特异性广谱抗菌特性，pH 值为碱性。此外，还公开了这些溶液的无菌制剂及其使用方法。
• Iyer, Radhakrishnan P.; Sonaseth, Mariam S.; Kulkarni, Subodh P., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 4, p. 289 - 290
  作者：Iyer, Radhakrishnan P.、Sonaseth, Mariam S.、Kulkarni, Subodh P.、Gopalan, R.、Ratnam, K. R.、Prabhu, A. V.

  DOI：——

  日期：——