2,3,4-三氟-1-丁氧基苯 | 1208078-33-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2,3,4-三氟-1-丁氧基苯
• 中文别名: 1-丁氧基-2,3,4-三氟苯
• 英文名称: 1-Butoxy-2,3,4-trifluorobenzene
• CAS: 1208078-33-4
• 化学式: C₁₀H₁₁F₃O
• mdl: MFCD13250185
• 分子量: 204.19
• InChiKey: SUQVNOJYWQZVTN-UHFFFAOYSA-N

物化性质

• 沸点：
  220℃
• 密度：
  1.162
• 闪点：
  93℃

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] BENZOHETEROCYCLIC COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS BENZOHÉTÉROCYCLIQUES ET LEUR UTILISATION
  申请人：TIANJIN BINJIANG PHARMA INC

  公开号：WO2013107283A1

  公开（公告）日：2013-07-25

  Disclosed are compound of formula (I) and pharmaceutically accepted salts and prodrugs thereof, wherein each of R1, R2, R3, R4, R5, R6, X1 and X2 is as defined in the description. These compounds are protein kinases inhibitors, especially the inhibitors of Mek, which are useful in the treatment of cancers and inflammation of mammals. Disclosed are the treatment methods of cancers and inflammation of mammals as well as pharmaceutical compositions comprising the compounds described herein. The preparation of benzoheterocyclic compounds are disclosed. Disclosed are the preparation of potential drug candidates, such as benzooxazol, benzothiazol, benzothiadiazol and the like.

  公开了式（I）的化合物及其药学上接受的盐和前药，其中R1、R2、R3、R4、R5、R6、X1和X2中的每一个如描述中所定义。这些化合物是蛋白激酶抑制剂，特别是Mek的抑制剂，对哺乳动物的癌症和炎症治疗有用。公开了治疗哺乳动物的癌症和炎症的治疗方法，以及包括本文描述的化合物的药物组合物。公开了苯杂环化合物的制备。公开了潜在药物候选物的制备，如苯氧唑、苯噻唑、苯噻二唑等。
• BENZOHETEROCYCLIC COMPOUNDS AND USE THEREOF
  申请人：TIANJIN BINJIANG PHARMA, INC.

  公开号：US20140371278A1

  公开（公告）日：2014-12-18

  Disclosed are compound of formula (I) and pharmaceutically accepted salts and prodrugs thereof, wherein each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X 1 and X 2 is as defined in the description. These compounds are protein kinases inhibitors, especially the inhibitors of Mek, which are useful in the treatment of cancers and inflammation of mammals. Disclosed are the treatment methods of cancers and inflammation of mammals as well as pharmaceutical compositions comprising the compounds described herein. The preparation of benzoheterocyclic compounds are disclosed. Disclosed are the preparation of potential drug candidates, such as benzooxazol, benzothiazol, benzothiadiazol and the like.

  本文披露了式(I)的化合物及其药用盐和前药，其中R1、R2、R3、R4、R5、R6、X1和X2中的每一个如描述中所定义。这些化合物是蛋白激酶抑制剂，特别是Mek的抑制剂，对哺乳动物的癌症和炎症的治疗有用。本文还披露了治疗哺乳动物癌症和炎症的方法，以及包括所述化合物的药物组合物。披露了苯杂环化合物的制备。还披露了潜在药物候选物的制备，如苯氧唑、苯噻唑、苯噻二唑等。
• US9290468B2
  申请人：——

  公开号：US9290468B2

  公开（公告）日：2016-03-22