2,3-二甲基-5-硝基-苯基胺 | 106837-44-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,3-二甲基-5-硝基-苯基胺
• 英文名称: 2,3-dimethyl-5-nitro-phenylamine
• 英文别名: 2,3-dimethyl-5-nitroaniline；2,3-dimethyl-5-nitro-aniline；2,3-Dimethyl-5-nitro-anilin；5-Nitro-3-amino-o-xylol；m-Nitro-o-xylidin；5-nitro-2,3-xylidine
• CAS: 106837-44-9
• 化学式: C₈H₁₀N₂O₂
• mdl: MFCD05664520
• 分子量: 166.18
• InChiKey: RSRLXRIHUGVPDS-UHFFFAOYSA-N

物化性质

• 熔点：
  110-111 °C
• 沸点：
  352.2±37.0 °C(Predicted)
• 密度：
  1.220±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  2,3-二甲基-5-硝基-苯基胺 生成 2,3-二甲苯酚,5-硝基-(6CI)
  参考文献：
  名称：

  Aleksandrov,I.V.; Abraduschkin,Yu.S., Journal of general chemistry of the USSR, 1960, vol. 30, p. 3374 - 3379

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3-二甲基苯胺 在 硫酸 、 硝酸 作用下， 以 ice-water 、 水 、 丙酮 为溶剂， 生成 2,3-二甲基-5-硝基-苯基胺
  参考文献：
  名称：

  Method for dyeing keratinous fibres using an aminoindole in combination

  摘要：

  将角蛋白纤维染色的方法，其特征在于至少将至少一种含有至少一种氨基吲哚的组合物（A）应用于适合染色的介质中，然后将该组合物（A）的应用前或后跟随着含有至少一种醌衍生物的组合物（B）的应用，该醌衍生物选择自邻苯醌或对苯醌、邻苯醌或对苯醌单亚胺或二亚胺、1,2-或1,4-萘醌、邻苯醌磺酰亚胺、α，ω-烷基-双1,4-苯醌，或1,2-或1,4-萘醌单亚胺或二亚胺，所选择的氨基吲哚和醌衍生物使得在磷酸盐介质中以伏安法在玻碳电极上测定的pH 7下的氨基吲哚的氧化还原电位E.sub.i和在磷酸盐介质中通过极谱法在pH 7下相对于饱和氯化汞电极测定的醌衍生物的氧化还原电位E.sub.q之间的差值ΔE，即ΔE=E.sub.i -E.sub.q ≤ 470毫伏。

  公开号：

  US05180400A1

文献信息

• PROTEIN KINASE C INHIBITORS AND USES THEREOF
  申请人：Singh Rajinder

  公开号：US20110130415A1

  公开（公告）日：2011-06-02

  This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

  这项披露涉及作为蛋白激酶C（PKC）抑制剂有用的化合物，因此对于治疗通过PKC活性介导或维持的各种疾病和疾病非常有用。这项披露还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和疾病的方法，制备这些化合物的过程以及在这些过程中有用的中间体。
• Methods for dyeing keratinous fibres with aminoindoles, compositions and
  申请人：L'Oreal

  公开号：US05254135A1

  公开（公告）日：1993-10-19

  Method for dyeing keratinous fibres, in particular human keratinous fibres, such as hair, characterized in that a composition (A) containing, in a medium appropriate for dyeing, at least one aminoindole corresponding to the formula: ##STR1## in which: R.sub.1 and R.sub.3, independently of one another, represent a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group; R.sub.2 denotes hydrogen or a C.sub.1 -C.sub.4 alkyl group or COOR', R' being a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group; R.sub.4 represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 hydroxyalkyl or C.sub.2 -C.sub.4 polyhydroxyalkyl group; Z.sub.1 represents a hydrogen or halogen atom or a C.sub.1 -C.sub.4 alkyl group or OR; R being a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group; and Z.sub.2 represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group; and its salts is applied to said fibres, the colour being developed with the aid of an oxidizing system.

  染发方法，特别是用于染人类角蛋白纤维，如头发，其特征在于使用一种含有在适宜染发介质中的至少一种氨基吲哚的组合物（A），该氨基吲哚符合以下通式：##STR1##其中：R1和R3各自独立地表示氢原子或C1-C4烷基；R2表示氢或C1-C4烷基或COOR'，其中R'为氢原子或C1-C4烷基；R4表示氢原子或C1-C4烷基、C1-C4羟烷基或C2-C4多羟烷基；Z1表示氢或卤素原子或C1-C4烷基或OR，其中R为氢原子或C1-C4烷基；Z2表示氢原子或C1-C4烷基；及其盐，将其施用于所述纤维上，并通过氧化体系进行着色。
• 2-imidazoline, 2-oxazoline, 2-thiazoline, and 4-imidazole derivatives of
  申请人：Syntex (U.S.A) Inc.

  公开号：US05952362A1

  公开（公告）日：1999-09-14

  The present invention concerns novel compounds represented by the Formula: ##STR1## wherein: A is R.sup.1.sub.q (R.sup.3 R.sup.60 N).sub.m (Z)(NR.sup.2).sub.n ; m and q are each 0 or 1, with the proviso that when q is 1, m is 0 and when q is 0, m is 1; Z is C.dbd.O or SO.sub.2 ; n is 1 with the proviso that, when Z is C.dbd.O, m is 1; X is --NH--, --CH.sub.2 --, or --OCH.sub.2 --; Y is 2-imidazoline, 2-oxazoline, 2-thiazoline, or 4-imidazole; R.sup.1 is H, lower alkyl, or phenyl, with the proviso that, when R.sup.1 is H, m is 1; R.sup.2, R.sup.3, R.sup.60 are each independently H, lower alkyl, or phenyl; R.sup.4, R.sup.5, R.sup.6, and R.sup.7 are each independently hydrogen, lower alkyl, --CF.sub.3, lower alkoxy, halogen, phenyl, lower alkeny, hydroxyl, lower alkylsulfonamido, or lower cycloalkyl, wherein R.sup.2 and R.sup.7 optionally may be taken together to form alkylene or alkenylene of 2 to 3 atoms in an unsubstituted or optionally substituted 5- or 6-membered ring, wherein the optional substituents on the ring are halo, lower alkyl, or --CN, with the proviso that, when R.sup.7 is hydroxyl or lower alkylsulfonamido, then X is not --NH-- when Y is 2-imidazoline. The compounds include pharmaceutically acceptable salts of the above. In the above formula A may be, for example, (R.sup.1 SO.sub.2 NR.sup.2 --), (R.sup.3 R.sup.60 NSO.sub.2 NR.sup.2 --), or (R.sup.3 R.sup.60 NCONR.sup.2 --). The invention also includes the use of the above compounds, and compositions containing them, as alpha.sub.1A/1L agonists in the treatment of various disease states such as urinary incontinence, nasal congestion, priapism, depression, anxiety, dementia, senility, Alzheimer's, deficiencies in attentiveness and cognition, and eating disorders such as obesity, bulimia, and anorexia.

  本发明涉及由以下式表示的新化合物：##STR1## 其中：A为R.sup.1_sub_q(R.sup.3 R.sup.60 N).sub.m(Z)(NR.sup.2).sub.n；m和q各为0或1，但条件是当q为1时，m为0，当q为0时，m为1；Z为C.dbd.O或SO.sub.2；n为1，但条件是当Z为C.dbd.O时，m为1；X为--NH--，--CH.sub.2--或--OCH.sub.2--；Y为2-咪唑啉，2-噁唑啉，2-硫唑啉或4-咪唑醇；R.sup.1为H，低碳烷基或苯基，但条件是当R.sup.1为H时，m为1；R.sup.2，R.sup.3，R.sup.60各自独立地为H，低碳烷基或苯基；R.sup.4，R.sup.5，R.sup.6和R.sup.7各自独立地为氢，低碳烷基，--CF.sub.3，低烷氧基，卤素，苯基，低烯基，羟基，低烷基磺酰胺基或低环烷基，其中R.sup.2和R.sup.7可选择地结合在一起形成未取代或可选择取代的5-或6-成员环的2至3个原子的烯烃或烷基，环上的可选择取代基为卤素，低碳烷基或--CN，但条件是当R.sup.7为羟基或低烷基磺酰胺基时，当Y为2-咪唑啉时，X不是--NH--。这些化合物包括上述的药用盐。在上述的式子中，A可以是(R.sup.1 SO.sub.2 NR.sup.2--)，(R.sup.3 R.sup.60 NSO.sub.2 NR.sup.2--)或(R.sup.3 R.sup.60 NCONR.sup.2--)。该发明还包括上述化合物的使用，以及含有它们的组合物，作为α.sub.1A/1L激动剂用于治疗各种疾病状态，如尿失禁、鼻塞、勃起异常、抑郁症、焦虑症、痴呆、老年痴呆症、阿尔茨海默氏病、注意力和认知缺陷、以及如肥胖症、暴食症和厌食症等的进食障碍。
• Method for dyeing keratinous fibres using an aminoindole in combination
  申请人：L'Oreal

  公开号：US05180400A1

  公开（公告）日：1993-01-19

  Method for dyeing keratinous fibres, characterized in that at least one composition (A) containing at least one aminoindole in a medium appropriate for dyeing is applied to these fibres, the application of the composition (A) being preceded or followed by the application of a composition (B) containing, in a medium appropriate for dyeing, at least one quinone derivative chosen from ortho- or para-benzoquinones, ortho- or para-benzoquinone monoimines or diimines, 1,2- or 1,4-naphthoquinones, ortho- or para-benzoquinone sulphonimides, .alpha.,.omega.-alkylene-bis-1,4-benzoquinones, or 1,2- or 1,4-naphthoquinone monoimines or diimines, the aminoindoles and the quinone derivatives being chosen such that the difference in redox potential .DELTA.E between the redox potential E.sub.i of the aminoindoles, determined at pH 7 in a phosphate medium on a vitreous carbon electrode by voltametry, and the redox potential E.sub.q of the quinone derivative, determined at pH 7 in a phosphate medium by polarography on a mercury electrode relative to the saturated calomel electrode, in such that .DELTA.E=E.sub.i -E.sub.q .ltoreq.470 mV.

  将角蛋白纤维染色的方法，其特征在于至少将至少一种含有至少一种氨基吲哚的组合物（A）应用于适合染色的介质中，然后将该组合物（A）的应用前或后跟随着含有至少一种醌衍生物的组合物（B）的应用，该醌衍生物选择自邻苯醌或对苯醌、邻苯醌或对苯醌单亚胺或二亚胺、1,2-或1,4-萘醌、邻苯醌磺酰亚胺、α，ω-烷基-双1,4-苯醌，或1,2-或1,4-萘醌单亚胺或二亚胺，所选择的氨基吲哚和醌衍生物使得在磷酸盐介质中以伏安法在玻碳电极上测定的pH 7下的氨基吲哚的氧化还原电位E.sub.i和在磷酸盐介质中通过极谱法在pH 7下相对于饱和氯化汞电极测定的醌衍生物的氧化还原电位E.sub.q之间的差值ΔE，即ΔE=E.sub.i -E.sub.q ≤ 470毫伏。
• Methods for dyeing keratinous fibers with compositions which contain
  申请人：L'Oreal

  公开号：US05752982A1

  公开（公告）日：1998-05-19

  A method for dyeing keratin fibers, wherein a composition is applied to said fibers which contains, in a suitable dyeing medium, at least one coupler having formula (I) ##STR1## wherein R.sub.1 is hydrogen or alkyl; R.sub.2 and R.sub.3 are hydrogen, alkyl, COOR', where R' is alkyl or hydrogen; R.sub.4 is hydrogen, hydroxyalkyl, alkyl, polyhydroxyalkyl or acetyl or aminoalkyl wherein the amine may be mono- or disubstituted by alkyl; Z.sub.1 and Z.sub.2 are hydrogen, alkyl, hydroxy, halogen, alkoxy or a salt thereof; at least one precursor of an oxidation hair dye; and at least one oxidizing agent, the pH of the composition applied to the fibers being less than 7.

  一种染色角蛋白纤维的方法，其中将含有至少一种具有以下式（I）的偶联剂的组合物施加到所述纤维中，其中R.sub.1为氢或烷基；R.sub.2和R.sub.3为氢、烷基、COOR'，其中R'为烷基或氢；R.sub.4为氢、羟基烷基、烷基、多羟基烷基或乙酰基或氨基烷基，其中胺基可以被烷基单取代或双取代；Z.sub.1和Z.sub.2为氢、烷基、羟基、卤素、烷氧基或其盐；至少一种氧化染发剂的前体；和至少一种氧化剂，施加到纤维上的组合物的pH值小于7。