2,3-二羟基-5-甲基苯甲酸甲酯 | 87567-91-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,3-二羟基-5-甲基苯甲酸甲酯
• 英文名称: 2,3-dihydroxy-5-methylbenzoic acid methyl ester
• 英文别名: methyl 2,3-dihydroxy-5-methyl benzoate；methyl 2,3-dihydroxy-5-methylbenzoate；2,3-dihydroxy-5-methylbenzoate
• CAS: 87567-91-7
• 化学式: C₉H₁₀O₄
• 分子量: 182.176
• InChiKey: JITDCMMXDJBYBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,3-二羟基-5-甲基苯甲酸甲酯 在 tert-butoxide 、 sodium sulfate 、 silver(l) oxide 作用下， 以 四氢呋喃 、 乙醚 、 氯仿 为溶剂， 反应 19.33h， 生成 8α-carbomethoxy-7-hydroxy-5-methyl-8(8aH)-oxo-1,4-dihydronaphthalene-1-acetic acid ethyl ester
  参考文献：
  名称：

  Quassinoid synthesis via o-quinone Diels-Alder reactions

  摘要：

  DOI：

  10.1021/jo00173a018
• 作为产物：
  描述：

  3-溴-2-羟基-5-甲基苯甲酸 在 盐酸 、 sodium hydroxide 、 三氟化硼乙醚 、 copper(II) sulfate 作用下， 以 水 为溶剂， 反应 10.0h， 生成 2,3-二羟基-5-甲基苯甲酸甲酯
  参考文献：
  名称：

  Quassinoid synthesis via o-quinone Diels-Alder reactions

  摘要：

  DOI：

  10.1021/jo00173a018

文献信息

• [EN] 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES AS 5HT4-ANTAGONISTS<br/>[FR] 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES SERVANT D'ANTAGONISTES DE 5HT4
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2005000838A1

  公开（公告）日：2005-01-06

  The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有5HT4拮抗性质的式(I)的新化合物。该发明还涉及制备这种新化合物的方法，包括将该新化合物作为药物的药物组合物以及该化合物的药用用途。
• [EN] AMINOSULFONYL SUBSTITUTED 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES AS 5HT4-ANTAGONISTS<br/>[FR] AMINOSULFONYLE SUBSTITUE 4-(AMINOMETHYLE)-PIPERIDINE BENZAMIDES UTILISE COMME 5HT4-ANTAGONISTES
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2005000837A1

  公开（公告）日：2005-01-06

  The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有5HT4-拮抗性质的式（I）的新化合物。该发明还涉及制备这种新化合物的方法，包括这些新化合物的药物组合物以及这些化合物作为药物的用途。
• [EN] HETEROCYCLIC SUBSTITUTED 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES AS 5HT4-ANTAGONISTS<br/>[FR] 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES SUBSTITUES PAR DES HETEROCYCLES, UTILISES COMME ANTAGONISTES DES RECEPTEURS 5HT4
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2005003124A1

  公开（公告）日：2005-01-13

  The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有5HT4拮抗性质的式(I)的新化合物。该发明还涉及制备这种新化合物的方法，包括这些新化合物的药用组合物以及这些化合物作为药物的用途。
• [EN] HYDROXYCARBONYLPHENYL SUBSTITUTED 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES AS 5HT4-ANTAGONISTS<br/>[FR] 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES SUBSTITUES PAR HYDROXYCARBONYLPHENYLE, UTILISES COMME ANTAGONISTES DES RECEPTEURS 5HT4
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2005003121A1

  公开（公告）日：2005-01-13

  The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有5HT4拮抗性质的式(I)的新化合物。该发明还涉及制备这种新化合物的方法，包括该新化合物的药物组合物以及该化合物的药用。
• Cephalosporin derivatives
  申请人：Mochida Pharmaceutical Co., Ltd.

  公开号：US04880798A1

  公开（公告）日：1989-11-14

  The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof. The present invention is based on the selection of groups containing a condensed heterocyclic ring, particularly a triazolopyrimidine ring, as substitutents at the 3-position of the cephem skeleton, and of groups containing a carboxyl and hydroxy substituted phenylmethyloxyimino moiety, particularly a (carboxy substituted catechol)methyloxyimino moiety, as substituents at the 7-position of the cephem skeleton. The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against Gram-negative bacteria and also against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.

  本发明涉及新型头孢菌素衍生物、其制备过程、用作活性成分预防和/或治疗传染病的组合物，以及头孢菌素衍生物合成中的中间化合物和其生产过程。本发明基于在头孢菌素骨架的3位选择含有紧缩杂环环，特别是三唑嘧啶环的取代基，以及在头孢菌素骨架的7位选择含有羧基和羟基取代的苯甲氧基亚胺基团，特别是含有（羧基取代的邻苯二酚）甲氧基亚胺基团的取代基。本发明中含有上述取代基的化合物对革兰氏阴性菌和包括耐甲氧西林金黄色葡萄球菌在内的革兰氏阳性菌具有强烈的抗菌活性。这些化合物对于治疗传染病非常有用。