2,4-二氯-N-异丙基苄胺 | 46190-62-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,4-二氯-N-异丙基苄胺
• 中文别名: (2,4-二氯-苄基)-异丙基-胺
• 英文名称: Isopropyl-<2,4-dichlor-benzyl>-amin
• 英文别名: (2,4-dichloro-benzyl)-isopropyl-amine；(2,4-Dichlor-benzyl)-isopropyl-amin；2,4-dichloro-N-isopropylbenzylamine；N-[(2,4-dichlorophenyl)methyl]propan-2-amine
• CAS: 46190-62-9
• 化学式: C₁₀H₁₃Cl₂N
• mdl: MFCD00127695
• 分子量: 218.126
• InChiKey: ZRTOSIHDTPDTMZ-UHFFFAOYSA-N

物化性质

• 沸点：
  126-127 °C(Press: 0.7 Torr)
• 密度：
  1.158±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2921499090

反应信息

• 作为反应物：
  描述：

  2,4-二氯-N-异丙基苄胺 、 4-cyano-5-[(2-ethylbutanoyl)amino]-3-methylthiophene-2-carboxylic acid 在 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 4-cyano-N-(2,4-dichlorobenzyl)-5-[(2-ethylbutanoyl)amino]-N-isopropyl-3-methylthiophene-2-carboxamide
  参考文献：
  名称：

  Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor

  摘要：

  A novel class of antagonists of the human glucagon receptor (bGCGR) has been discovered. Systematic modification of the lead compound identified substituents that were essential for activity and those that were amenable to further optimization. This SAR exploration resulted in the synthesis of 13, which exhibited good potency as an hGCGR functional antagonist (IC50 = 34 nM) and moderate bioavailability (36% in mice). (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.01.003

文献信息

• Tachykinin receptor antagonists
  申请人：Amegadzie Kudzovi Albert

  公开号：US20060160794A1

  公开（公告）日：2006-07-20

  The present invention relates to selective NK-1 receptor antagonists of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.

  本发明涉及公式(I)或其药学上可接受的盐的选择性NK-1受体拮抗剂，用于治疗与过量Tachykinins相关的疾病。
• Method of treating diabetes and related conditions
  申请人：Duffy Joseph

  公开号：US20060035958A1

  公开（公告）日：2006-02-16

  The present invention addresses the use of substituted thiophene derivatives, as well as compositions containing such compounds for treating type 2 diabetes mellitus. The compounds in the present invention are glucagon antagonists. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose providing a treatment of diabetes.

  本发明涉及使用取代噻吩衍生物以及含有这些化合物的组合物来治疗2型糖尿病。本发明中的化合物是胰高血糖素拮抗剂。这些化合物阻止胰高血糖素在其受体上的作用，从而降低血浆葡萄糖水平，提供糖尿病治疗。
• Dpp-iv inhibitors
  申请人：Edwards John Paul

  公开号：US20070197522A1

  公开（公告）日：2007-08-23

  The invention relates to compounds of formula (I) Z-C(R 1 R 2 )—C(R 3 NH 2 )—C(R 4 R 5 )—X—N(R 6 R 7 )  (I), wherein Z, R 1-7 and X have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereof as medicament.

  该发明涉及式（I）的化合物：Z-C（R1R2）-C（R3NH2）-C（R4R5）-X-N（R6R7）（I），其中Z，R1-7和X的含义如所述。所述化合物可用作DPP-IV抑制剂。该发明还涉及制备这种化合物以及其作为药物的生产和使用。
• Alicyclic Heterocyclic Compound
  申请人：Furukubo Shigeru

  公开号：US20090182140A1

  公开（公告）日：2009-07-16

  An alicyclic heterocyclic compound represented by the following formula or a pharmaceutically acceptable salt thereof: wherein ring A is a heterocyclic ring, ring B is a carbocyclic ring, a heterocyclic ring etc., P 1 and P 2 are CH or N, q and r are 0 to 2, X is —NH—, —O—, —CH 2 —, etc., Y is —CH 2 —, —CO—, —SO 2 —, etc., Z is —CO—, —SO 2 —, etc., and R 3 is carbocyclic group, heterocyclic group, hydroxyl, alkoxy or amino, is useful as a controlling agent of the function of CCR 4 useful for the prevention or treatment for bronchial asthma, atopic dermatitis, etc.

  以下式子所示的脂环杂环化合物或其药学上可接受的盐： 其中环A为杂环，环B为碳环，杂环等，P1和P2为CH或N，q和r为0至2，X为—NH—，—O—，—CH2—等，Y为—CH2—，—CO—，—SO2—等，Z为—CO—，—SO2—等，R3为碳环基团，杂环基团，羟基，烷氧基或氨基，用作CCR4功能调节剂，用于预防或治疗支气管哮喘，特应性皮炎等。
• FR2234293
  申请人：——

  公开号：——

  公开（公告）日：——