氯达酮 | 4755-59-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 氯达酮
• 英文名称: Clodazon
• 英文别名: 5-chloro-1-(3-dimethylamino-propyl)-3-phenyl-1,3-dihydro-benzoimidazol-2-one；5-chloro-1-[3-(dimethylamino)propyl]-3-phenylbenzimidazol-2-one
• CAS: 4755-59-3
• 化学式: C₁₈H₂₀ClN₃O
• 分子量: 329.829
• InChiKey: VWXGRWMELBPMCU-UHFFFAOYSA-N

物化性质

• 沸点：
  201.5°C (rough estimate)
• 密度：
  1.2068 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  26.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Pharmaceutical preparation comprising an active dispersed on a matrix
  申请人：——

  公开号：US20040058896A1

  公开（公告）日：2004-03-25

  The present invention relates to the field of pharmaceutical technology and describes a novel advantageous preparation for an active ingredient. The novel preparation is suitable for producing a large number of pharmaceutical dosage forms. In the new preparation an active ingredient is present essentially uniformly dispersed in an excipient matrix composed of one or more excipients selected from the group of fatty alcohol, triglyceride, partial glyceride and fatty acid ester.

  本发明涉及制药技术领域，描述了一种新的有利的活性成分制备方法。这种新的制备方法适用于生产大量的药物剂型。在这种新的制备方法中，活性成分基本上均匀地分散在由脂肪醇、甘油三酯、部分甘油酯和脂肪酸酯等多种赋形剂中选择的一种或多种赋形剂组成的赋形剂基质中。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Novel Pharmaceutical Compositions for Treating Chronic Pain and Pain Associated with Neuropathy
  申请人：Singh Chandra U.

  公开号：US20130189354A1

  公开（公告）日：2013-07-25

  The present invention relates to compositions and methods for treating pain wherein the compositions comprise a combination of tramadol or a pharmaceutically acceptable salt thereof, magnesium or a pharmaceutically acceptable salt thereof; and gabapentin or pregabalin. The therapeutic combination can further contain capsaicin or an ester of capsaicin.

  本发明涉及用于治疗疼痛的组合物和方法，其中所述组合物包括曲马多或其药学上可接受的盐、镁或其药学上可接受的盐；以及加巴嘌醇或普瑞巴林。治疗组合物还可以包含辣椒素或辣椒素酯。
• PHARAMACEUTICAL COMPOSITIONS FOR TREATING CHRONIC PAIN AND PAIN ASSOCIATED WITH NEUROPATHY
  申请人：Singh Chandra Ulagaraj

  公开号：US20110039875A1

  公开（公告）日：2011-02-17

  The present invention provides methods and compositions for the treatment of neuropathic pain. In certain embodiments, compositions comprising an dextromethorphan (or other N-methyl-D-aspartate receptor antagonist), tramadol, and gabapentin can synergistically act to reduce pain in a human patient. Pharmaceutical compositions may also comprise a capsaicinoid, an esterified capsaicinoid, and/or a tricyclic antidepressant.

  本发明提供了治疗神经病痛的方法和组合物。在某些实施例中，含有右美沙芬（或其他N-甲基-D-天门冬氨酸受体拮抗剂）、曲马多和加巴喷丁的组合物可以协同作用于人类患者，以减轻疼痛。药物组合物也可以包括辣椒素类、酯化辣椒素类和/或三环抗抑郁剂。
• Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
  申请人：Nlife Therapeutics S.L.

  公开号：EP2380595A1

  公开（公告）日：2011-10-26

  The invention provides a conjugate comprising (i) a nucleic acid which is complementary to a target nucleic acid sequence and which expression prevents or reduces expression of the target nucleic acid and (ii) a selectivity agent which is capable of binding with high affinity to a neurotransmitter transporter. The conjugates of the present invention are useful for the delivery of the nucleuc acid toi cell of interests and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of contrast agents to the cells for diagnostic purposes.

  本发明提供了一种共轭物，该共轭物包含(i)与靶核酸序列互补的核酸，该核酸的表达可防止或减少靶核酸的表达；(ii)能够与神经递质转运体高亲和力结合的选择剂。本发明的共轭物可用于将核酸递送至相关细胞，从而治疗需要下调靶核酸编码蛋白的疾病，也可用于将造影剂递送至细胞以进行诊断。