2,4-二甲基苯乙基乙醇 | 6597-59-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,4-二甲基苯乙基乙醇
• 英文名称: 2,4-dimethylphenethyl alcohol
• 英文别名: 2-(2,4-dimethylphenyl)ethanol；2,4-dimethylphenethylalcohol；2,4-dimethyl-phenethyl alcohol；2,4-Dimethyl-phenaethylalkohol；2-Hydroxy-1-(2.4-dimethyl-phenyl)-aethan；1-(2.4-Dimethyl-phenyl)-aethanol-(2)
• CAS: 6597-59-7
• 化学式: C₁₀H₁₄O
• 分子量: 150.221
• InChiKey: CRFNQKYHIUVLSQ-UHFFFAOYSA-N

物化性质

• 沸点：
  125 °C(Press: 10 Torr)
• 密度：
  0.988 g/cm3(Temp: 26 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2906299090

反应信息

• 作为反应物：
  描述：

  2,4-二甲基苯乙基乙醇 以 水 为溶剂， 反应 2.0h， 生成 2-[2-(2,4-Dimethylphenyl)ethylamino]guanidine
  参考文献：
  名称：

  芳烷基氨基胍和相关化合物。

  摘要：

  DOI：

  10.1021/jm00300a007
• 作为产物：
  描述：

  2-(2,4-二甲基苯基)乙酸甲酯 在 lithium aluminium tetrahydride 作用下， 生成 2,4-二甲基苯乙基乙醇
  参考文献：
  名称：

  阿扎霉素的化学研究。3.碱性降解阿扎霉素-B。

  摘要：

  碱性降解由透明链霉菌（Streptomyces hygroscopicus var. azalomyceticus）产生的一种大环内酯类抗生素偶氮霉素-B，可得到辛-4-烯-3-酮（II）、不饱和酮醇（X）和 2,4-二甲基苯乙酸（VIII），以及更低级的降解产物。根据对这些产物结构的阐明，提出了这种抗生素的部分结构（XIV）。

  DOI：

  10.1248/cpb.15.1726

文献信息

• Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US20030064991A1

  公开（公告）日：2003-04-03

  Disclosed are novel compounds having the formula 1 or a physiologically acceptable salt, amide, ester or prodrug thereof. The compounds can be used to modulate (antagonize, agonize) chemokine receptor function. Also disclosed is a method for treating a patient having an inflammatory disease and/or viral infection comprising administering an effective amount of a compound of Formula I. In particular embodiments, the invention is a method for treating a patient infected with HIV.

  揭示了具有以下结构式的新化合物 1 或其生理上可接受的盐、酰胺、酯或前药。这些化合物可用于调节（拮抗、激动）趋化因子受体功能。还揭示了一种治疗患有炎症性疾病和/或病毒感染的患者的方法，包括给予结构式I的化合物的有效量。在特定实施例中，本发明是一种治疗感染HIV的患者的方法。
• LOW VISCOSITY LOW VOLATILITY LUBRICATING OIL BASE STOCKS AND METHODS OF USE THEREOF
  申请人：ExxonMobil Research and Engineering Company

  公开号：US20170183595A1

  公开（公告）日：2017-06-29

  A lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein. The lubricating oil base stock has a high temperature high shear (HTHS) viscosity of less than about 1.7 cP as determined by ASTM D4683, and a Noack volatility from about 15 to about 90 percent as determined by ASTM D5800. A lubricating oil containing the lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein. A method for improving one or more of thermal and oxidative stability, solubility and dispersancy of polar additives, deposit control and traction control in a lubricating oil by using as the lubricating oil a formulated oil containing the lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein.

  一种润滑油基础油，包括根据本文所定义的公式(I)、(II)、(III)和(IV)表示的一个或多个单酯。该润滑油基础油的高温高剪切（HTHS）粘度小于约1.7厘泊，由ASTM D4683确定，挥发性从约15%到约90%，由ASTM D5800确定。一种含有根据本文所定义的公式(I)、(II)、(III)和(IV)表示的一个或多个单酯的润滑油基础油的润滑油。一种通过使用包含根据本文所定义的公式(I)、(II)、(III)和(IV)表示的一个或多个单酯的润滑油基础油的配制油来改善润滑油中的热稳定性、氧化稳定性、溶解性和分散性、沉积控制和牵引控制的方法。
• [EN] AMINOBENZIMIDAZOLES AND BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION<br/>[FR] AMINOBENZIMIDAZOLES ET BENZIMIDAZOLES UTILISES EN TANT QU'INHIBITEURS DE LA REPLICATION DU VIRUS SYNCYTIAL RESPIRATOIRE
  申请人：TIBOTEC PHARM LTD

  公开号：WO2005058869A1

  公开（公告）日：2005-06-30

  Aminobenzimidazoles and benzimidazoles having inhibitory activity on RSV replication and having the formula (I) the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; wherein G is a direct bond or C1-10alkanediyl optionally substituted with one or more hydroxy, C1-6alkyloxy, Ar1Cl-6alkyloxy, C1-6alkylthio, Ar1C1-6alkylthio, HO(-CH2-CH2-O)n-, C1-6alkyloxy(-CH2-M2-O)n- or Ar1Cl-6alkyloxy(-CH2-C2-O)n-; R1 is Ar1 or a monocyclic or bicyclic heterocycle; Q is hydrogen, amino or mono- or di(C1-4alkyl)amino; one of R2a and R3a is selected from halo, optionally mono- or polysubstituted C1-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar2, N(R4aR4b), N(R4aR4b)sulfonyl, N(R4aR4b)carbonyl, C1-6alkyloxy, Ar2oxy, Ar2C1-6alkyloxy, carboxyl, C1-6alkyloxycarbonyl, or -C(=Z)Ar2; and the other one of R2a and R3a is hydrogen; in case R2a is different from hydrogen then R2b is hydrogen, C1-6alkyl or halogen and R3b is hydrogen; in case R3a is different from hydrogen then R3b is hydrogen, C1-6alkyl or halogen and R2b is hydrogen. Compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.

  氨基苯并咪唑和对RSV复制具有抑制活性的苯并咪唑，其具有式(I)的前药、N-氧化物、加合盐、季铵盐、金属配合物和立体化学异构体形式；其中G是直接键或C1-10烷二基，可选地取代一个或多个羟基、C1-6烷氧基、Ar1Cl-6烷氧基、C1-6烷基硫氧基、Ar1C1-6烷基硫氧基、HO(-CH2-CH2-O)n-、C1-6烷氧基(-CH2-M2-O)n-或Ar1Cl-6烷氧基(-CH2-C2-O)n-；R1是Ar1或单环或双环杂环；Q是氢、氨基或单或双(C1-4烷基)氨基；R2a和R3a中的一个选择自卤素、可选地单或多取代的C1-6烷基、可选地单或多取代的C2-6烯基、硝基、羟基、Ar2、N(R4aR4b)、N(R4aR4b)磺酰基、N(R4aR4b)羰基、C1-6烷氧基、Ar2氧基、Ar2C1-6烷氧基、羧基、C1-6烷氧羰基或-C(=Z)Ar2；R2a和R3a中的另一个是氢；如果R2a不同于氢，则R2b是氢、C1-6烷基或卤素，而R3b是氢；如果R3a不同于氢，则R3b是氢、C1-6烷基或卤素，而R2b是氢。含有这些化合物作为活性成分的组合物以及制备这些化合物和组合物的方法。
• Aromatic<i>β</i>-Silylethenylation Reactions via Organogallium Compounds
  作者：Yoshiyuki Kido、Satoru Yoshimura、Masahiko Yamaguchi、Tadafumi Uchimaru

  DOI：10.1246/bcsj.72.1445

  日期：1999.7

  The reaction proceeded via cationic species generated by the interaction of GaCl3 and silylethyne. High reactivity of the intermediate was demonstrated by the rapid reaction rate at −78 °C using close to the equimolar amount of the substrates. ipso-Substitution reaction took place with 1,2,3-trimethoxybenzene. Structures and properties of several organogallium compounds involved in the reactions are

  在 GaCl3 存在下，甲硅烷基乙炔与芳烃发生亲电反应，得到 β-甲硅烷基乙烯化芳烃。该反应通过由 GaCl3 和甲硅烷基乙炔相互作用产生的阳离子物质进行。使用接近等摩尔量的底物，在 -78 °C 下的快速反应速率证明了中间体的高反应性。1,2,3-三甲氧基苯发生同位取代反应。讨论了参与反应的几种有机镓化合物的结构和性质。
• Offender Risk and Needs Assessment: Some Current Issues and Suggestions
  作者：Mitchell K. Byrne、Stuart Byrne、Katherine Hillman、Emma Stanley

  DOI：10.1375/bech.18.1.18

  日期：2001.4.1

  Crime impacts upon the community at multiple levels, causing distress and loss for the victims, and feelings of insecurity for the public, as well as adding to the drain on financial resources for governments. This makes the accurate identification of risk of reoffending and the determination of efficacious rehabilitation strategies imperative. Key principles in cognitive and behavioural psychology can contribute to this task. This paper will review the issue of risk assessment and describe the applicability of functional analysis to forensic psychology. Two studies by the authors will be used to illustrate concepts raised in this review. The paper will conclude with a model that may help guide the realistic implementation of detailed individual functional analyses of offenders' behaviour.

  摘要：犯罪对社区造成多层次影响，给受害者带来痛苦和损失，给公众带来不安感，同时增加政府财政资源的消耗。准确识别再犯风险和确定有效的康复策略至关重要。认知和行为心理学的关键原则可以为这一任务做出贡献。本文将审查风险评估问题，并描述功能分析在法庭心理学中的适用性。作者进行的两项研究将用来阐明本文中提出的概念。本文将以一个模型结尾，该模型可能有助于指导对罪犯行为进行详细个体功能分析的现实实施。

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