氰甲基甲基(4-吡啶)氨基二硫代甲酸酯 | 1158958-89-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 氰甲基甲基(4-吡啶)氨基二硫代甲酸酯
• 英文名称: cyanomethyl methyl(pyridin-4-yl)carbamodithioate
• 英文别名: Cyanomethyl methyl(4-pyridyl)carbamodithioate；cyanomethyl N-methyl-N-pyridin-4-ylcarbamodithioate
• CAS: 1158958-89-4
• 化学式: C₉H₉N₃S₂
• 分子量: 223.323
• InChiKey: URLWWHOJXDIKQC-UHFFFAOYSA-N

物化性质

• 熔点：
  129-132°C &_& 3652-3697°C (lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  97.3
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  4-甲氨基吡啶 、 二硫化碳 、 溴乙腈 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 以59%的产率得到氰甲基甲基(4-吡啶)氨基二硫代甲酸酯
  参考文献：
  名称：

  Benaglia, Massimo; Chiefari, John; Chong, Yen K., Journal of the American Chemical Society, 2009, vol. 131, p. 6914 - 6915

  摘要：

  DOI：

文献信息

• Polymeric prodrugs and subcutaneous and/or intramuscular administration thereof
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US20200353090A1

  公开（公告）日：2020-11-12

  The invention relates to new prodrugs of active molecules. These prodrugs allow, in particular, the subcutaneous or intramuscular administration of active molecules of which the subcutaneous or intramuscular administration is problematic or impossible, in particular because of the toxicity at the injection site. The prodrugs according to the invention comprise an active ingredient, covalently linked with a polymer chain, preferably a hydrophilic and/or thermosensitive polymer chain. The invention relates, in particular, to polymeric prodrugs comprising a polymer chain formed at least in part by acrylamide monomer or one of its derivatives, the polymer comprising a proximal part and a terminal part; a first pharmaceutically active molecule covalently coupled to the proximal part of the polymer; possibly a second pharmaceutically active molecule covalently coupled to the terminal part of the polymer.

  该发明涉及新型活性分子的前药。这些前药允许特别是将活性分子皮下或肌肉内注射，而这些活性分子的皮下或肌肉内注射由于在注射部位的毒性而具有问题或不可能，特别是由于在注射部位的毒性。根据本发明的前药包括一种活性成分，与一根聚合物链共价连接，优选为一种亲水性和/或热敏感性聚合物链。该发明特别涉及包括由丙烯酰胺单体或其衍生物之一至少部分形成的聚合物链的聚合物前药，该聚合物包括一个近端部分和一个末端部分；第一种药用活性分子共价结合到聚合物的近端部分；可能第二种药用活性分子共价结合到聚合物的末端部分。
• Polymerizable sulfonamide compounds and polymers thereof
  申请人：Massachusetts Institute of Technology

  公开号：US11155674B2

  公开（公告）日：2021-10-26

  Methods, compositions, reagents, and systems that allow for the preparation and utilization of sulfonamide salt polymer electrolytes are disclosed herein. Methods and reagents to prepare sulfonamide salt monomers are also disclosed herein. The sulfonamide salt polymer electrolytes can be used as components in energy storage devices, conductive materials, electrochemical cells, gels, adhesives, and drug delivery vehicles.

  本文公开了允许制备和利用磺胺盐聚合物电解质的方法、组合物、试剂和系统。本文还公开了制备磺胺盐单体的方法和试剂。磺胺盐聚合物电解质可用作能量存储设备、导电材料、电化学电池、凝胶、粘合剂和药物输送载体中的组件。
• RAFT POLYMERISATION
  申请人：Rizzardo Ezio

  公开号：US20120004381A1

  公开（公告）日：2012-01-05

  A method of preparing polymer, the method comprising polymerising one or more ethylenically unsaturated monomers of formula (I) where U is selected from H, C 1 -C 4 alkyl or halogen; V is halogen or of the form O-G where G is selected from —C(O)R 1 and —R 1 , or V is of the form NGG a where G is as defined above and G a is selected from H and R 1 , G and G a form together with N a heterocyclic ring, or V is of the form CH 2 G b where G b is selected from H, R 1 , OH, OR 1 , NR 1 2 , PR 1 2 , P(O)R 1 2 , P(OR 1 ) 2 , SR 1 , SOR 1 , and SO 2 R 1 ; and where the or each R 1 is independently selected from optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, optionally substituted alkylaryl, optionally substituted alkylheteroaryl, and an optionally substituted polymer chain, under the control of a RAFT agent of formula (II) or (III), where Y is a Lewis base moiety and Y* is an n-valent Lewis base moiety; X is O or NR 1 , R 1 is as defined above or forms together with Y or Y* and N a heterocyclic ring; m is an integer ≧1; n is an integer ≧2; and where R* is a m-valent radical leaving group that affords R*. which initiates free radical polymerisation of the one or more ethylenically unsaturated monomers of formula (I), and R is a free radical leaving group that affords R. which initiates free radical polymerisation of the one or more ethylenically unsaturated monomers of formula (I).

  一种制备聚合物的方法，该方法包括聚合一个或多个具有化学式（I）的乙烯基不饱和单体，其中U选择自H，C1-C4烷基或卤素; V为卤素或形式为O-G的形式，其中G选择自—C（O）R1和—R1，或V为形式为NGGa的形式，其中G如上所定义，Ga选择自H和R1，G和Ga与N一起形成杂环环，或V为形式为CH2Gb的形式，其中Gb选择自H，R1，OH，OR1，NR12，PR12，P（O）R12，P（OR1）2，SR1，SOR1和SO2R1;其中每个R1是独立选择自可选取代烷基，可选取代烯基，可选取代炔基，可选取代芳基，可选取代杂芳基，可选取代碳环烷基，可选取代杂环烷基，可选取代芳基烷基，可选取代杂芳基烷基，可选取代烷基芳基，可选取代烷基杂芳基和可选取代聚合物链，受公式（II）或（III）的RAFT试剂的控制，其中Y是路易斯碱基团，Y *是n价路易斯碱基团; X为O或NR1，R1如上所定义或与Y或Y *和N一起形成杂环环; m为整数≧1; n为整数≧2;其中R *是m价基团离去基团，提供R *，其引发具有化学式（I）的一个或多个乙烯基不饱和单体的自由基聚合，R是自由基离去基团，提供R，其引发具有化学式（I）的一个或多个乙烯基不饱和单体的自由基聚合。
• Raft polymerisation
  申请人：Rizzardo Ezio

  公开号：US09340498B2

  公开（公告）日：2016-05-17

  A method of preparing polymer, the method comprising polymerizing one or more ethylenically unsaturated monomers of formula (I) where U is selected from H, C1-C4 alkyl or halogen; V is halogen or of the form O-G where G is selected from —C(O)R1 and —R1, or V is of the form NGGa where G is as defined above and Ga is selected from H and R1, G and Ga form together with N a heterocyclic ring, or V is of the form CH2Gb where Gb is selected from H, R1, OH, OR1, NR12, PR12, P(O)R12, P(OR1)2, SR1, SOR1, and SO2R1; and where the or each R1 is independently selected from optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, optionally substituted alkylaryl, optionally substituted alkylheteroaryl, and an optionally substituted polymer chain, under the control of a RAFT agent of formula (II) or (III), where Y is a Lewis base moiety and Y* is an n-valent Lewis base moiety; X is O or NR1, R1 is as defined above or forms together with Y or Y* and N a heterocyclic ring; m is an integer ≧1; n is an integer ≧2; and where R* is a m-valent radical leaving group that affords R*. which initiates free radical polymerization of the one or more ethylenically unsaturated monomers of formula (I), and R is a free radical leaving group that affords R. which initiates free radical polymerization of the one or more ethylenically unsaturated monomers of formula (I).

  一种制备聚合物的方法，包括在RAFT试剂的控制下聚合一个或多个式(I)的乙烯基不饱和单体，其中U从H、C1-C4烷基或卤素中选择；V为卤素或形式为O-G的形式，其中G从—C(O)R1和—R1中选择，或V为形式为NGGa的形式，其中G如上所定义，Ga从H和R1中选择，G和Ga与N一起形成杂环环，或V为形式为CH2Gb的形式，其中Gb从H、R1、OH、OR1、NR12、PR12、P(O)R12、P(OR1)2、SR1、SOR1和SO2R1中选择；其中每个R1独立地从可选取代的烷基、可选取代的烯基、可选取代的炔基、可选取代的芳基、可选取代的杂芳基、可选取代的碳环基、可选取代的杂环基、可选取代的芳基烷基、可选取代的杂芳基烷基、可选取代的烷基芳基、可选取代的烷基杂芳基和可选取代的聚合物链中独立选择；RAF试剂的式(I)或(III)，其中Y是一个Lewis碱基团，Y*是一个n价Lewis碱基团，X为O或NR1，R1如上所定义或与Y或Y*和N一起形成杂环环，m为一个≧1的整数，n为一个≧2的整数，其中R*是一个m价基团离去基团，提供R*，它引发式(I)的一个或多个乙烯基不饱和单体的自由基聚合，R是一个自由基离去基团，提供R，它引发式(I)的一个或多个乙烯基不饱和单体的自由基聚合。
• ALKENYL ETHER-VINYL ESTER COPOLYMER
  申请人：Maruzen Petrochemical Co., Ltd.

  公开号：EP3296333A1

  公开（公告）日：2018-03-21

  To provide a temperature responsive polymer that has an arbitrary LCST in a wide temperature range of from a low temperature range of body temperature or room temperature to a high temperature range of 80°C or more, and to provide a method capable of providing the polymer easily. An alkenyl ether-vinyl ester copolymer containing a repeating unit derived from a hydroxyl group-containing alkenyl ether represented by the formula (1), and a repeating unit derived from a vinyl ester represented by the formula (2), and exhibiting temperature responsiveness showing a change in hydrophilicity and hydrophobicity at a prescribed temperature as a critical point, and the alkenyl ether-vinyl ester copolymer that has a lower critical solution temperature to water of from 1°C to 99°C: wherein R1, R2, and R3 each independently represent a hydrogen atom or an alkyl group having a number of carbon atoms of from 1 to 4; R4 represents a linear or branched alkylene group having a number of carbon atoms of from 2 to 4; R5 represents an acyl group having a number of carbon atoms of from 1 to 20; and p represents an integer of from 1 to 3.

  提供一种温度响应性聚合物，该聚合物在从体温或室温的低温范围到 80°C 或更高的高温范围的宽温度范围内具有任意的 LCST，并提供一种能够轻松提供该聚合物的方法。一种烯基醚-乙烯基酯共聚物，其含有由式(1)表示的含羟基烯基醚衍生的重复单元和由式(2)表示的乙烯基酯衍生的重复单元，并具有温度响应性，在规定温度作为临界点时亲水性和疏水性发生变化，该烯基醚-乙烯基酯共聚物对水的临界溶液温度较低，为1℃至99℃： 其中 R1、R2 和 R3 各自独立地代表氢原子或碳原子数为 1 至 4 的烷基；R4 代表碳原子数为 2 至 4 的直链或支链亚烷基；R5 代表碳原子数为 1 至 20 的酰基；p 代表 1 至 3 的整数。