2,5-二甲氧基-4-吗啉苯胺 | 68052-18-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: 2,5-二甲氧基-4-吗啉苯胺
• 英文名称: 2,5-dimethoxy-4-morpholinoaniline
• 英文别名: 2,5-dimethoxy-4-morpholin-4-ylaniline
• CAS: 68052-18-6
• 化学式: C₁₂H₁₈N₂O₃
• mdl: MFCD22377491
• 分子量: 238.287
• InChiKey: UPKAFSNUROXYDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• 2, 4-Pyrimidinediamines Useful In The Treatment Of Neoplastic Diseases, Inflammatory And Immune System Disorders
  申请人：Garcia-Echeverria Carlos

  公开号：US20080132504A1

  公开（公告）日：2008-06-05

  Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them

  式I的新型嘧啶衍生物及其制备方法，它们的药用价值以及包含它们的药物组合物。
• PYRIMIDINE DERIVATIVES
  申请人：Garcia-Echeverria Carlos

  公开号：US20110201606A1

  公开（公告）日：2011-08-18

  Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them

  式I的新型嘧啶衍生物及其制备方法，其用作药物和含有它们的药物组合物。
• 2,4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS
  申请人：Garcia-Echeverria Carlos

  公开号：US20110098280A1

  公开（公告）日：2011-04-28

  Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

  I类新型嘧啶衍生物的制备方法，以及它们作为药物和药物组合物的用途。
• 2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
  申请人：Novartis AG

  公开号：EP2287156A1

  公开（公告）日：2011-02-23

  Novel pyrimidine derivatives of formula (I) and their use for the manufacture of a medicament for the treatment or prevention of a disease which responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR. in which: n' is selected from 1,2 and 3; R'1is selected from phenyl, pyridinyl, pyrazolyl and pyrimidinyl; and R'2 and R'3 are as described herein.

  式(I)的新型嘧啶衍生物及其用于制造治疗或预防对抑制FAK和/或ALK和/或ZAP-70和/或IGF-IR有反应的疾病的药物。 其中：n'选自 1、2 和 3； R'1 选自苯基、吡啶基、吡唑基和嘧啶基； 以及 R'2 和 R'3 如本文所述。
• 2, 4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS
  申请人：Novartis AG

  公开号：EP1660458B1

  公开（公告）日：2012-01-25