2,6-二甲基-4-氰基吡啶 | 39965-81-6

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2,6-二甲基-4-氰基吡啶
• 中文别名: 2,6-二甲基异烟腈；2,6-二甲基-4-氰基-吡啶
• 英文名称: 2,6-dimethylisonicotinonitrile
• 英文别名: 2,6-dimethyl-4-cyanopyridine；4-cyano-2,6-dimethylpyridine；4-cyano-2,6-lutidine；2,6-dimethylpyridine-4-carbonitrile；2,6-Dimethyl-4-cyanopyridin
• CAS: 39965-81-6
• 化学式: C₈H₈N₂
• mdl: MFCD00152363
• 分子量: 132.165
• InChiKey: TXBLTSMCEXEFMI-UHFFFAOYSA-N

物化性质

• 熔点：
  80-82℃
• 沸点：
  229℃
• 密度：
  1.05
• 闪点：
  92℃

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  36.7
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险等级：
  6.1
• 安全说明：
  S26
• 危险类别码：
  R36
• 海关编码：
  2933399090
• 危险标志：
  GHS06
• 危险性描述：
  H301,H319
• 危险性防范说明：
  P301 + P310,P305 + P351 + P338
• 储存条件：
  室温

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2,6-Dimethylpyridine-4-carbonitrile
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 2,6-Dimethylpyridine-4-carbonitrile
CAS number: 39965-81-6

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C8H8N2
Molecular weight: 132.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2,6-二甲基-4-氰基吡啶 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以78%的产率得到2,6-二甲基-4-吡啶甲酸
  参考文献：
  名称：

  一系列高效荧光pH探针的光物理性质，用于水溶液中的双发射波长测量。

  摘要：

  本文评估了5-芳基-2-吡啶基恶唑主链，以设计一或两个光子吸收后的供体-受体荧光pH探针。可以容易地以高收率容易地获得母体荧光团以及可用于标记生物分子的衍生物。这些分子在近紫外范围内显示出大的单光子吸收，并具有覆盖整个可见域的强荧光发射。5-芳基-2-吡啶基恶唑衍生物还具有明显的截面，用于吸收两个光子。吡啶质子化后，在单光子和双光子激发后的吸收光谱中以及发射光谱中观察到了大的位移。此功能用于测量所研究化合物的pK（a），范围在2至8之间。在大多数所研究的衍生物中，pK（a）随光激发而增加，并且在激发态的寿命期间发生质子交换，如相位调制荧光法分析所示。建议使用几种5-芳基-2-吡啶基恶唑衍生物作为有效探针，以依赖于荧光发射的比例法可靠地测量水溶液的pH。

  DOI：

  10.1002/chem.200500619
• 作为产物：
  描述：

  2,6-二甲基吡啶 N-氧化物 以 水 为溶剂， 反应 26.0h， 生成 2,6-二甲基-4-氰基吡啶
  参考文献：
  名称：

  一系列高效荧光pH探针的光物理性质，用于水溶液中的双发射波长测量。

  摘要：

  本文评估了5-芳基-2-吡啶基恶唑主链，以设计一或两个光子吸收后的供体-受体荧光pH探针。可以容易地以高收率容易地获得母体荧光团以及可用于标记生物分子的衍生物。这些分子在近紫外范围内显示出大的单光子吸收，并具有覆盖整个可见域的强荧光发射。5-芳基-2-吡啶基恶唑衍生物还具有明显的截面，用于吸收两个光子。吡啶质子化后，在单光子和双光子激发后的吸收光谱中以及发射光谱中观察到了大的位移。此功能用于测量所研究化合物的pK（a），范围在2至8之间。在大多数所研究的衍生物中，pK（a）随光激发而增加，并且在激发态的寿命期间发生质子交换，如相位调制荧光法分析所示。建议使用几种5-芳基-2-吡啶基恶唑衍生物作为有效探针，以依赖于荧光发射的比例法可靠地测量水溶液的pH。

  DOI：

  10.1002/chem.200500619

文献信息

• Lewis Basic Salt-Promoted Organosilane Coupling Reactions with Aromatic Electrophiles
  作者：Tyler W. Reidl、Jeffrey S. Bandar

  DOI：10.1021/jacs.1c05764

  日期：2021.8.11

  Lewis basic salts promote benzyltrimethylsilane coupling with (hetero)aryl nitriles, sulfones, and chlorides as a new route to 1,1-diarylalkanes. This method combines the substrate modularity and selectivity characteristic of cross-coupling with the practicality of a base-promoted protocol. In addition, a Lewis base strategy enables a complementary scope to existing methods, employs stable and easily

  路易斯碱性盐促进苄基三甲基硅烷与（杂）芳基腈、砜和氯化物的偶联，作为制备 1,1-二芳基烷烃的新途径。该方法将交叉耦合的底物模块化和选择性特征与碱基促进协议的实用性结合起来。此外，路易斯碱策略能够对现有方法进行补充，采用稳定且易于制备的有机硅烷，并在酸性官能团存在下实现选择性芳基化。该方法的实用性通过药物类似物的合成及其在多组分反应中的应用得到证明。
• NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES
  申请人：Bolli Martin

  公开号：US20110046170A1

  公开（公告）日：2011-02-24

  The invention relates to novel pyrimidine-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  本发明涉及新颖的嘧啶-吡啶衍生物、其制备方法及其作为药理活性化合物的应用。这些化合物特别作为免疫调节剂发挥作用。
• PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS
  申请人：Bolli Martin

  公开号：US20110212998A1

  公开（公告）日：2011-09-01

  The invention relates to novel pyridine derivatives of formula (D, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula (I) wherein A represents and the other substituents are as defined in the claims.

  本发明涉及式（D）的新吡啶衍生物、它们的制备方法以及它们作为药物活性化合物的用途。所述化合物特别是作为免疫调节剂发挥作用。式（I）中，A代表，其他取代基如权利要求中所定义。
• Synthesis of Sterically Hindered Primary Amines by Concurrent Tandem Photoredox Catalysis
  作者：Michael C. Nicastri、Dan Lehnherr、Yu-hong Lam、Daniel A. DiRocco、Tomislav Rovis

  DOI：10.1021/jacs.9b10871

  日期：2020.1.15

  methodologies exist for amine synthesis, but the direct synthesis of primary amines with a fully substituted α carbon center is an underdeveloped area. We report a method which utilizes photoredox catalysis to couple readily available O-benzoyl oximes with cyanoarenes to synthesize primary amines with fully substituted α-carbons. We also demonstrate that this method enables the synthesis of amines with α-trifluoromethyl

  伯胺是活性药物成分 (API) 及其中间体的重要结构基序，也是用于生物或催化应用的配体库的成员。胺合成有许多化学方法，但直接合成具有完全取代的 α 碳中心的伯胺是一个欠发达的领域。我们报告了一种利用光氧化还原催化将容易获得的 O-苯甲酰基肟与氰基芳烃偶联以合成具有完全取代的 α-碳的伯胺的方法。我们还证明该方法能够合成具有 α-三氟甲基官能团的胺。根据实验和计算结果，
• [EN] NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRIMIDINE-PYRIDINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2009109907A1

  公开（公告）日：2009-09-11

  The invention relates to novel pyrimidine-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula I.

  本发明涉及新颖的嘧啶-吡啶衍生物、其制备方法及其作为药理活性化合物的应用。所述化合物特别作为免疫调节剂发挥作用。式I。